<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18218

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSIERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRHWDCIWDPGTRGWGEAQVLPTQLPRLNKAVYPNAQRSSWTPVVLEASYPPPFCFLGIIEGETWTLSAGYPRLGFFLGSCLRREGSRPRAPSLLPHPLPSALQF
Length2169
PositionKinase
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.432
Instability index54.03
Isoelectric point6.66
Molecular weight241714.11
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18218
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.02|      16|      16|    2027|    2042|       1
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 1901- 1916 (28.61/10.74)	QQQPAVPQGQ...RLRQQL
 2026- 2041 (32.82/13.25)	EQQQQQQQQQ...QQQQQQ
 2042- 2060 (29.59/11.32)	QQQQQQQQQQyhiRQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     240.71|      35|      36|    1917|    1951|       2
---------------------------------------------------------------------------
 1790- 1819 (30.56/11.68)	.......GKKR.........SQPATKTEDYGMGP...GRS.GPYgvtVPP
 1834- 1864 (44.43/20.69)	NYRQGSIGLYT.........QNQPLPA...GGPR...VDPYRP....VRL
 1867- 1894 (35.33/14.77)	QKLPTRPTYPG.........VLPTTMTGVMGLEP...SS....Y......
 1917- 1951 (62.30/32.31)	QQSQGMLGQSS.........VHQMTPSSSYGLQT...SQGYTPY...VSH
 1955- 1994 (41.57/18.83)	QQHTGPADPTRhlqqrpsgyVHQQAPTYGHGLTS...TQRF.......SH
 1997- 2025 (26.52/ 9.05)	LQQTPM..............ISTMTPMSAQGVQTgvrSTAILP.......
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      21|      36|     138|     158|       3
---------------------------------------------------------------------------
  138-  158 (36.83/20.24)	KKEEVFGYLAKYTVPVMRAAW
  176-  196 (38.55/21.50)	KKRNVVDPFTEWTQIITKYLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     854|     868|       4
---------------------------------------------------------------------------
  854-  868 (26.85/16.07)	LEQITSFALG.MSYHL
  870-  885 (23.14/12.84)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      88.30|      14|      15|    1735|    1748|       5
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  641-  651 (18.04/ 6.19)	PAD...DPERKEAE
 1735- 1748 (26.63/13.18)	PRAYYLEPLPLPPE
 1753- 1766 (25.22/12.03)	PAPTLLEPEKKAPE
 1767- 1778 (18.41/ 6.49)	P.PKTDKPGAAPP.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1028|    1040|       6
---------------------------------------------------------------------------
 1028- 1040 (25.11/14.21)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/10.73)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.26|      20|      21|    1290|    1310|       7
---------------------------------------------------------------------------
 1092- 1106 (19.39/ 9.26)	.EWLG..VLKALC........CSSNN..
 1290- 1309 (38.44/30.52)	QEWVGERCLKSLC........EDSNDLQ
 1314- 1341 (25.43/11.28)	SSAQAQRLMQLICyphrlldnEDGENPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.60|       8|      16|    1672|    1681|       8
---------------------------------------------------------------------------
 1672- 1681 (10.11/10.56)	IFkkEGLQVS
 1691- 1698 (15.50/ 7.90)	LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.51|      15|      22|    2105|    2122|       9
---------------------------------------------------------------------------
 2105- 2122 (29.31/27.03)	WTpvvLEASYPPPFCFLG
 2129- 2143 (32.20/19.87)	WT...LSAGYPRLGFFLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.77|      12|      43|     926|     937|      10
---------------------------------------------------------------------------
  926-  937 (25.05/16.41)	CIVAVLRH.YHAC
  971-  983 (20.72/12.25)	CILAYLYDlYTSC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.70|      20|      22|    1549|    1570|      11
---------------------------------------------------------------------------
 1549- 1570 (29.77/28.95)	QRstQQTTEW..AVL.LLEIIISGT
 1572- 1594 (24.93/16.13)	DM..QSNNELftTVLdMLSVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     663|     122|     135|      12
---------------------------------------------------------------------------
  122-  135 (24.94/16.29)	GTKPLTQLAKKVPI
  787-  800 (25.11/16.46)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.98|      16|      43|     942|     957|      13
---------------------------------------------------------------------------
  942-  957 (27.58/17.04)	QDQMAQVFEGLCGVVK
  987- 1002 (27.40/16.88)	KNKFGELFSDFCSKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.64|      32|     200|    1234|    1267|      16
---------------------------------------------------------------------------
 1234- 1267 (52.83/31.07)	AELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR
 1434- 1468 (46.82/21.78)	AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.74|       9|      19|    1661|    1670|      18
---------------------------------------------------------------------------
 1661- 1670 (11.73/10.42)	TKgNKIAGFD
 1682- 1690 (18.01/10.08)	TK.QKLSPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      22|      22|    1612|    1633|      21
---------------------------------------------------------------------------
 1612- 1633 (34.88/23.16)	RAYMNLAKKLQKELGERQSDSL
 1637- 1658 (37.82/25.89)	RQLLPLPKQTRDVITCEPQGSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     314.13|     104|     233|     285|     402|      22
---------------------------------------------------------------------------
  285-  402 (157.42/145.82)	SGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvISAQSTSTlPTTPAPQPPTSSTPSTPfSDLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPLDHlPIAP
  518-  637 (156.70/102.92)	SGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..IASGSLSA.PSAPIFQDVLLQFLDTQ.APMLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAPGPR.PPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.37|      28|      29|    1154|    1181|      28
---------------------------------------------------------------------------
 1115- 1148 (24.55/ 9.54)	..LCNVDVSDlsfHDSLA..TfvailiAR.QC.LLLEDLI
 1154- 1181 (51.16/28.01)	PSLLNAACSE...QDSEP..G......ARLTC.RILLHLF
 1184- 1209 (28.66/12.39)	PQLN..PCQS...DGNKPtvG......IRSSCdRHLL...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.26|      13|     233|     217|     229|      30
---------------------------------------------------------------------------
  217-  229 (25.30/14.55)	GSTIGPLPHDVEV
  451-  463 (23.96/13.36)	GFTIGRVLHTLEV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18218 with Med12 domain of Kingdom Metazoa
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