<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18211
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKEMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTATPQTQLQLQQVALQQQQQQQQQQFQQQAALQQQQQQQQFQVQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPMVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA |
Length | 788 |
Position | Tail |
Organism | Aotus nancymaae (Ma's night monkey) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae>
Aotus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.708 |
Instability index | 88.02 |
Isoelectric point | 9.49 |
Molecular weight | 86884.72 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18211
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.98| 17| 19| 438| 456| 5
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277- 293 (32.78/ 7.35) QQPQPPPSQALP...QQLQQ
445- 464 (31.19/ 9.77) PQSMPPPPQPSPqpgQPGSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.85| 16| 34| 82| 104| 6
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87- 104 (27.42/21.17) SLTGGPAAGAAgiGMPPR
124- 139 (33.43/10.18) SLSGQPPPGTS..GMAPH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 140.07| 32| 151| 548| 582| 9
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549- 582 (51.47/27.94) MINKIDKNEDrkKDLSKMKSL.LDILTDPSKRCPL
585- 610 (40.99/18.06) L....QKCEI...ALEKLKND.MAVPTPPPPPVP.
706- 735 (47.61/19.73) LICKLD...D..KDLPSVPPLeLSVPADYPAQSPL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 191.74| 43| 92| 399| 441| 11
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342- 384 (56.10/18.43) TQ.PPLKFVRAPmvvqqPQVQPQVQQQTAVQTAQTA...QMVA...PGVQ
399- 441 (79.46/29.76) ARFPPTTAVSAI.....PSSSIPLGRQPMAQVSQSSL..PMLSSPSPGQQ
495- 531 (56.18/18.47) ARTPQNFSV........PSPG.PLN.TP...VNPSSVmsPAGSSQAEEQQ
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