<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18207

Description Transducin beta like 1 X-linked
SequenceMTELTGASSRCCPRPARRGAMQSPVDHVQRLRGREGGSHSASTSSQRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAASAATSTTAGVSQQNPPKNAQTPVNGEEIRAHDINNHVKPMEVDGEIEIPSNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGCSTQLVLRHCIREGGHDVPSNKDVTSLDWNTDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCERPVKTFQGHTNEVNAIKWDPSGILLASCSDDMTLKIWSMKQEVCVHDLQAHSKEIYTIKWSPSGPATSNPNSKIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQNGNLVYSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Length568
PositionTail
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.363
Instability index40.10
Isoelectric point5.95
Molecular weight61875.43
Publications









Function






Annotated function


GO - Cellular Component
histone deacetylase complex	GO:0000118	IEA:Ensembl
mitotic spindle	GO:0072686	IEA:Ensembl
transcription repressor complex	GO:0017053	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:Ensembl
histone binding	GO:0042393	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
transcription factor binding	GO:0008134	IEA:Ensembl
transcription regulatory region sequence-specific DNA binding	GO:0000976	IEA:Ensembl

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:Ensembl
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl
proteolysis	GO:0006508	IEA:Ensembl
sensory perception of sound	GO:0007605	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18207
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     399.62|      40|      40|     376|     415|       1
---------------------------------------------------------------------------
  219-  248 (32.74/13.49)	...............LRGHESEVFICAWNPVS.........dlL.A.SGS.GDSTAR
  249-  266 (24.83/ 8.70)	IW.NL.NEN..................................S.N.GCS.TQLVLR
  267-  302 (36.35/15.68)	HCiREG.GHD..VPS....NKDVTSLDWNTDG.........tlL.A.TGS.YD.GF.
  303-  345 (36.29/15.65)	.A.RIWTEDGnlASTLGQHKGPIFALKWNRKG..........nY.IlSAG.VDKTTI
  346-  386 (54.24/26.53)	IW.DAHTGEA..KQQFPFHSAPALDVDWQNN..........ttF.A.SCS.TDMCIH
  387-  428 (62.77/31.70)	VC.RLGCERP..VKTFQGHTNEVNAIKWDPSG.........ilL.A.SCS.DDMTLK
  429-  479 (57.16/28.30)	IW.SMKQEVC..VHDLQAHSKEIYTIKWSPSGpatsnpnskimL.A.SAS.FDSTVR
  483-  521 (50.32/24.15)	VE.RGVC.....IHTLTKHQEPVYSVAFSPDG..........kYlA.SGS.FDKCVH
  522-  563 (44.92/20.88)	IW.NTQNGNL..VYSYRG.TGGIFEVCWNARG........dkvG.A.SASdGSVCV.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18207 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTGASSRCCPRPARRGAMQSPVDHVQRLRGREGGSHSASTSSQRGEA
2) SAATSTTAGVSQQNPPKNAQTPVNGEEIRAHDINNHVKPMEVDGEIEIPSNKA
4
164
50
216










Molecular Recognition Features






MoRF SequenceStartStop




1) PRPARRG
13
19