<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18197
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDDEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLMSKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQSPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPNLQLSISLCHSSNDKKSQKFATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKVITLSYQEQELQDFLLSQFVMDLKVAAKLWFSFPVISVKTFQKVMFYKTPNGVIFVGHSKKFIGIKWKVETLFIKWSCLFSRNFDLKLLFLKIIIRKCVFSTLSAFTL |
Length | 597 |
Position | Head |
Organism | Aotus nancymaae (Ma's night monkey) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae>
Aotus.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.305 |
Instability index | 51.14 |
Isoelectric point | 8.74 |
Molecular weight | 67439.74 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18197
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 150.05| 48| 110| 280| 330| 1
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280- 330 (74.69/49.09) PLPKSKP.GspHWQTKLEAAQnVLLCKEIFAQLSREAV..QIKSQIPHIVVKNQ
393- 443 (75.36/40.08) PHPASAPfG..HKRMRLSGPQ.AFDKNEINSLQSSEGLleKIIKQAKHIFLRSR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.84| 15| 15| 518| 532| 3
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518- 532 (27.76/17.68) LWFSFP..VISVKTFQK
534- 550 (23.07/13.55) MFYKTPngVIFVGHSKK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.96| 25| 318| 158| 183| 5
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158- 183 (37.92/27.78) QILL..KGAERLTKSVTEN.QENKLQrDF
476- 503 (35.04/20.68) KVLItsQGYEQICKVITLSyQEQELQ.DF
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