<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18180

Description Uncharacterized protein
SequenceATAPCPGIFFINILRILARFFSPKCKYLLLLFQNAFSVFQDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGGGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACILPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSAELNNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQKSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVQQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKMSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPKPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDHGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHTITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1275
PositionKinase
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.370
Instability index56.22
Isoelectric point8.28
Molecular weight142822.55
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18180
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.06|      26|      27|    1211|    1236|       1
---------------------------------------------------------------------------
  779-  804 (36.68/17.14)	RQKQK...SMSLLSQQPFLSLVLTCLKGQ
 1215- 1240 (45.86/23.34)	QQQQR...LLRQAQTRPFQQFPRQGLQQT
 1241- 1265 (25.52/ 9.60)	QQQQQtaaLVRQLQKQLSSNQPQQG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.26|      22|      27|     436|     461|       2
---------------------------------------------------------------------------
  436-  461 (31.98/31.98)	LLAAACGdaDAEPGARMTCRllLHLF
  468-  489 (42.28/27.13)	ILPQATG..KPFPGIRSSCD..RHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.08|      25|      27|     833|     857|       3
---------------------------------------------------------------------------
  808-  837 (29.74/17.82)	REGLLT.SLQNQVNQIlsnwrEERYQDDIKA
  838-  862 (40.65/27.29)	RQMMHE.ALQLRLNLV.....GGMFDTVQKS
  863-  883 (18.69/ 8.22)	TQWTTDwALLLLQIIT.....SGTVD.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     189|     205|       4
---------------------------------------------------------------------------
  189-  205 (22.97/19.13)	LLLKSSSLAGSYtTGLC
  219-  234 (29.21/19.28)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.02|      25|      28|    1162|    1186|       5
---------------------------------------------------------------------------
 1162- 1186 (42.34/28.09)	GSRLDPAGSFVPTNTKQALS.NMLQR
 1189- 1214 (38.68/24.94)	GAMMQPPSLHTITSQQQLIQmKLLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.19|      21|      28|     955|     976|       6
---------------------------------------------------------------------------
  955-  975 (38.58/25.68)	KQTCDVITCEPMGS..LIDTKGN
  986- 1008 (31.61/14.98)	KQGLQVSTKQKMSPwdLFEGQKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.15|      35|      38|     622|     656|       7
---------------------------------------------------------------------------
  593-  614 (22.24/ 8.42)	...CTD..KELI....LDPVLSNMQAQKLL..Q......
  622-  656 (60.27/34.67)	IKECTE..GDNLQRQHIKRILQNLEQWTLR..QSWLELQ
  659-  696 (42.64/22.50)	IKQCLKdpGSG.SVAEMNNLLDNIAKATIEvfQQSAELN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.89|      24|      30|     345|     371|       8
---------------------------------------------------------------------------
  345-  371 (38.86/35.96)	MGHQDA..GRINDIANFSSELtacCTV....LS
  375-  404 (35.04/22.59)	LGVLKAlcCSSNHVWGFNDVL...CTVdvsdLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.83|      22|      27|    1043|    1064|       9
---------------------------------------------------------------------------
 1043- 1064 (39.26/25.41)	KPKPRSYYLEPLPLPPEEEEEE
 1072- 1093 (35.57/22.30)	EPERKSAELSDHGKTTTDEEKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.76|      12|      31|      57|      68|      10
---------------------------------------------------------------------------
   57-   68 (21.82/15.14)	GVGKERDEARHQ
   89-  100 (21.94/15.26)	GGGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.25|      13|      19|    1104|    1116|      11
---------------------------------------------------------------------------
 1104- 1116 (24.16/12.18)	SSRVDEYPQSNIY
 1126- 1138 (27.09/14.43)	SSQMMHHPQSTLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.12|      12|      44|     207|     218|      12
---------------------------------------------------------------------------
  207-  218 (25.08/14.20)	CIVAVLRR.YHSC
  252-  264 (21.04/10.92)	CILAYLYDlYVSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.11|      10|      19|     536|     546|      14
---------------------------------------------------------------------------
  536-  546 (16.69/13.88)	CdGNADDIWTA
  553-  562 (18.42/ 9.75)	C.GKSISIETA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18180 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHTI
2) RQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDHGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
1149
1222
1047
1200
1275
1131










Molecular Recognition Features






MoRF SequenceStartStop




1) RSYYLEPLPLP
1047
1057