<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18179

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLAEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSTQCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQKKRKYSASSGGLCEEETAAKVASWDFVEATQRTNCSCLRHKNLKPRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVAMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFPPQFQEAVEPTVYVGTAVNLEEDEASIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAVASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTGHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHINGGLKESEKLPDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLVTPSQMANTGNANTPSTTLASAASTTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGHLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEAHDEVPNILQQPLALGYFVSTAKAGPLPNWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.08
Grand average of hydropathy-0.389
Instability index52.43
Isoelectric point5.45
Molecular weight239394.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18179
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     977.30|     369|     422|    1263|    1683|       1
---------------------------------------------------------------------------
 1263- 1460 (200.64/146.31)	..............................................................................................................................................................................................................................................................PWSkrndVSMQ...CSQDIL.......RMLL....S..LQPVLQD.AIQKKRTVRPWgvqgPlTWQQFHKMAGRGSYGTDESPEPLP.IPTFLLGYDYDYlVLSPFALPYWErlMLEPYG..SQR.DIAYVVLC..PENEALLNGAKSFFRDLtaiYESCRLGQHRPISRLLTDGIMR...........VGSTASKKLSEKLVAEWFSQAADG............NNEAFSKlKLyAQVCRYdL
 1461- 1899 (519.66/362.35)	GPYLASLPldsSLLSqPNLVA..PTSQSLVTPSQMaNTGNANTPSTTLASAASTTMTM..TSGVAI.....STSVATANSTLTTastssssssnlnsgvsSNKLPSFPPfgsmNSNAAGSMSTqANTVQSGhlGGQQPSALQ..TAGISGESSSLPIQ..PH.PDVSE.STMDRdKVGIPTDGDSHAITYPPAIVVYIIDpftyeNKDESTNSSNVWT...LGLLRCFLEMVQTLPPHIKS...................tVSVQiipC.QYLLqpvkhedRQIY....TqhLKSLAFS.AFTQCR..RPL....P.TSTNVKTLTGFGPGLAMETALRSPdRPECIRLYAPPF.ILAPVKDKQTE..LGETFGeaGQKyNVLFVGYClsHDQRWILASCTDLYGEL...LETCIINIDVPNRARRKKGSARkfglqklwewcLGLVQMSSLPWRVVIGRLGRIGHGelkdwscllsrrNLQSLSK.RL.KDMCRM.C
 1900- 2157 (257.00/139.54)	GISAADSP...SILS.ACLVAmePQGSFVIMPDSV.STGSVFGRSTTLNMQTSQLNTPqdTSCTHIlvfptSASVQVASATYTT................ENLDLAFNP....NNDGADGMGI.FDLLDTG..DDLDPDIINilPASPTGSPVHSPGShyPHgGDVGKgQSTDR.LLSTEAHDEVPNILQQPLALGYFVS.....TAKAGPLPNWFWSacpQAQYQCPLFLKASLHLHVPSvqsdellhskhshPLD.....SNQ...TS.DVL.......RFVLeqynA..LSWLTCDpAIQDRRSCLP............................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.15|      51|      68|     924|     988|       2
---------------------------------------------------------------------------
  924-  975 (92.94/41.02)	PSQCLPPIkLPEECIYR.QSWTVGKLELLPSGPAMPFIKEGDGSNMDQE.YGPA
  993- 1045 (84.21/50.83)	PSNSGAGI.LPSPSTPRfPTPRTPRTPRTPRGAGGPASAQGSVKYENSDlYSPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.57|      66|      69|     782|     850|       3
---------------------------------------------------------------------------
  781-  849 (107.13/65.65)	TDLDNLFNSDEDELTPGSKKSANGSDDKASCK.ESKTGNLDPLSCiSTADLHKMYptPPSLEQHIMG...FSP
  850-  919 (108.44/57.34)	MNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKiEVDEGFCSPKPS.EIKDFSYVY..KPENCQILVGcsmFAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     411.57|     127|     714|     312|     486|       4
---------------------------------------------------------------------------
  312-  448 (188.12/104.45)	PaSTRDPAMSSVTLTPPTSPEEVQTVDpQSAQKwVKFSSVSDGFNSDSTSHhgGKIPRKLANHVVDRVWQE..CNMNRAQKKRKYSASSGGLCEEEtaAKVAsWDFVEATQRTNCSCLRHKnlKPRNAGQQGQAPSLGQ
  520-  648 (223.45/132.44)	P.QMHGTEMANSPQPPPLSPHPCDVVD.EGVTK.TPSTPQSQHFYQMPTPD..PLVPSKPVEDRIDSLSQSfpPQFQEAVEPTVYVGTAVNLEEDE..ASIA.WKYYKVPKKKDVEFLPPQ..LPSDKFKDDPVGPFGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.59|      26|     715|      36|      64|       5
---------------------------------------------------------------------------
   36-   64 (41.00/35.22)	QGPTSAPILfpvTEEDPILSSFSRCLKAD
  730-  755 (44.60/28.43)	DGTSSVTVL...SHEEDAMSLFSPSIKQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.30|      26|      28|    1098|    1125|       7
---------------------------------------------------------------------------
 1100- 1125 (49.73/34.48)	MNIK.GADVGVYIPDPTQEVQYRCTCG
 1130- 1156 (42.57/21.35)	MNRKfGNNSGLFLEDELDIIGRNTDCG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18179 with Med13 domain of Kingdom Metazoa
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