<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18172

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPAAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLVRTGLVGLGLGWGGPRGCPQGTVGASGATGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLMSGGPRGPVPQPGLQPSVMEDDILMDLI
Length486
PositionUnknown
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.05
Grand average of hydropathy-0.300
Instability index59.56
Isoelectric point9.56
Molecular weight50507.63
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18172
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     307.38|      70|      70|     232|     301|       3
---------------------------------------------------------------------------
  184-  256 (78.63/18.53)	P..QQ.LLTTLGPLFRNSRM....................VQfhftNKDLESL.KglyRIMGNGFA.........GCVhfpHTAPCE..VRV....LMLLYSSKKKIFMGLI
  257-  335 (110.49/29.57)	PYDQSGFVNGIRQVITNHKQ....................VQ....QQKLEQQ.Q...RGMGGQQAP...PG..LGPIledQARPSQnlVRTglvgLGLGWGGPRGCPQGTV
  336-  373 (54.92/10.32)	..GASG.ATGQPQ....PQS....................TA....QPPPGAP.Q...GPPGAASGP...PP..PGPI..................................
  393-  465 (63.35/13.24)	PPPQ....TGVPP....PQAslhhlqppgapallppphqgLG....QPQLGPPlL...HPPPAQSWPtqlPPraPLPG...Q...............MLMSGGPRG......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.97|      20|      20|      80|      99|       5
---------------------------------------------------------------------------
   80-   99 (37.94/14.27)	VAPG..SG.LAPAAQPGAPSMAG
  101-  121 (29.38/ 9.30)	VAPGgvSG.PSP.AQLGAPALGG
  129-  149 (26.66/ 7.73)	LLAW..SGvLEWQEKPKPASVDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18172 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPPAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPAAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) GWGGPRGCPQGTVGASGATGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLMSGGPRGPVPQPGLQPSVMEDDILMD
3) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQ
50
323
274
120
484
310










Molecular Recognition Features






MoRF SequenceStartStop




NANANA