<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18167

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPAAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLVRTGLVGLGLGWGGPRGCPQGTVGASGATGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLMSGGPRGPVPQPGLQPSVMEDDILMDLI
Length756
PositionUnknown
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.05
Grand average of hydropathy-0.222
Instability index58.71
Isoelectric point8.69
Molecular weight78859.69
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18167
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.04|      34|      38|     308|     345|       2
---------------------------------------------------------------------------
  314-  351 (62.56/19.50)	PGVGPPfsqaPAPPLPPGPP...GAPKPPPASQPSLVSTVA
  352-  386 (42.13/ 6.86)	PGSG......LAPAAQPGAPsmaGTVAPGGVSGPSPAQLGA
  618-  648 (51.35/10.34)	STAQPP......PGAPQGPP...GAASGPPPPGP.ILRPQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      24|      30|     238|     263|       3
---------------------------------------------------------------------------
  233-  261 (30.35/10.34)	GSapgPlQPKqPVPLPPAAPSGATLSAAP
  593-  616 (39.38/ 9.56)	GW...G.GPR.GCPQGTVGASGATGQPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.59|      23|      66|     649|     672|       4
---------------------------------------------------------------------------
  649-  672 (45.06/15.12)	PGaNPQLRSLLLNPPPPQ...TGVPPP
  695-  720 (42.42/11.09)	LG.QPQLGPPLLHPPPAQswpTQLPPR
  724-  744 (34.11/ 7.29)	PG..QMLMSGGPRGPVPQ...PGLQP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.16|      43|      66|      86|     130|       5
---------------------------------------------------------------------------
   86-  130 (71.01/54.83)	APTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFddFKK
  155-  197 (73.15/49.58)	AVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLL..FEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.50|      36|      66|     455|     505|       6
---------------------------------------------------------------------------
  472-  534 (40.57/40.89)	QFhFTN.KDLES..LKGLYRIMGnGfagcvhfphtapcevrvlmllysskKKIFMGLIP.YDQ.SGFV
  539-  579 (46.93/22.24)	QV.ITNhKQVQQqkLEQQQRGMG.G.........................QQAPPGLGPiLEDqARPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.83|      30|     268|       2|      32|       7
---------------------------------------------------------------------------
    2-   32 (48.90/36.31)	VPGSEGPARAGGLVAdVVFVIEGTANLGPYF
  274-  303 (50.93/32.74)	VPGNLSAAQVAAQNA.VEAAKNQKAGLGPRF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18167 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPAAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) GWGGPRGCPQGTVGASGATGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLMSGGPRGPVPQPGLQPSVMEDDILMD
3) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQ
232
593
544
390
754
580










Molecular Recognition Features






MoRF SequenceStartStop




1) LMDLI
752
756