<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18153

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGSSGGPQSAPAPPPPGAAVAAAAAAAASPGYRLMPRNPCLFLKIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTICSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNASDREDSPATALLLQQLKENIQELVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGASSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPSLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1431
PositionTail
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.06
Grand average of hydropathy-0.194
Instability index52.78
Isoelectric point9.04
Molecular weight158008.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18153
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     310.95|      60|      64|     979|    1040|       1
---------------------------------------------------------------------------
    9-   47 (30.44/ 7.93)	............HQLVPPgggggsSG.GPQSAPA.....PPP.....................................PGAAVAAAAaaaASP.........
  979- 1010 (51.13/19.10)	.......................................PPPQQQPFPKQ.............................PGTSGAYPL...TSPPTSYHSTVN
 1013- 1069 (93.33/44.17)	PSMMHTQSPGNLHAASSP......SGALRAPSPAsfvptPPPSSHGISIG.............................PGASFA.......SP....HGTLD
 1070- 1108 (71.55/27.96)	PSSPYT........MVSP......SG..RAG..............NWPGS.............................PQVSGPSPA...TRMPG..MSPAN
 1109- 1191 (64.50/24.16)	PS.LHSPVPDASH...SP.....rAGASSQTMPT...nmPPPRKLP...QrswaasiptilthsalnilllpsptpglvPSLAGSY.L...CSPLERFLGSV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.80|      51|     508|     306|     356|       3
---------------------------------------------------------------------------
  306-  356 (92.07/73.77)	YHAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP
  789-  855 (60.73/45.55)	YGTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     249.88|      71|     504|     126|     196|       4
---------------------------------------------------------------------------
   88-  140 (54.83/28.82)	.....................KVEKCAMISSfLDQQAILFVDTADRLASLARDALVH........arLPSFAIPYAIDVLTT
  141-  212 (109.26/64.72)	GSYPRLPTCIRDKIIPPDPITKIEKQATLHQ.LNQILRHRLVTTDLPPQLANLTVAN........grV.KFRVEGEFEATLT
  215-  285 (85.79/49.24)	GDDPDVPWRLLKLEILVEDKETGDGRALVHS.MQINFIHQLVQSRL...FAD.....ekplqdmyncLHSFCLSLQLEVL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.16|      21|      31|    1203|    1225|       9
---------------------------------------------------------------------------
 1203- 1225 (31.81/29.90)	QETLQL.INSNEPGviMFKTDALK
 1235- 1256 (34.34/24.62)	NQTLQLkVTPENAG..QWKPDELQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.57|      25|     393|     549|     573|      12
---------------------------------------------------------------------------
  549-  573 (40.50/24.79)	SVNASDREDSPATALLLQQLKENIQ
  954-  978 (45.07/28.52)	SVNEDDNPPSPIGGDMMDSLISQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.21|      29|     393|     869|     903|      13
---------------------------------------------------------------------------
  869-  903 (40.43/44.32)	GLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDI
 1268- 1296 (53.78/34.39)	GPPFKANTLI.AFTKLLGAPTHI...LRD..CVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1340|    1363|      16
---------------------------------------------------------------------------
 1339- 1362 (39.65/20.42)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1363- 1388 (34.41/16.67)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18153 with Med14 domain of Kingdom Metazoa
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