<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18152

Description Mediator complex subunit 14
SequenceMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTICSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNASDREDSPATALLLQQLKENIQELVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGASSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPSLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1388
PositionTail
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index51.70
Isoelectric point9.00
Molecular weight154323.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18152
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1007.71|     331|     392|     581|     955|       1
---------------------------------------------------------------------------
  581-  955 (501.20/440.94)	MCDTNMPfVGLRLELS...NLEIPHQGVQV.EGDGFSHAIrllKIPPckGISEET.QKALDRSLLDCTFRLQGRNNrTWV.AELVFANCP...LNGTStrEQGPSRHVylTYENLLSEPVGGRKVVEMFLN..........DW.NSIAR.LYECVLEFArSLPDiPAHLNIFSEVRVYnyrkliLCYGTTK..GSSI...SIQwNSIHQKfhiSLGTVGPN.SGCSNCHNTILHQLQEMFNKTPNVVQlLQVLFDTQA...P..LNAINKLPTVPMLGLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDIYcrsrGVVAIRDGAYSLFDNSKLVEGFYPA......PG.....LKTFLNMFVdsnQDARRRSVneddnPPS.PIggDMMDSLISQL.QPPPQQQPFPKQPGTSGAYPL
  972- 1347 (506.51/324.88)	MMHTQSP.GNLHAASSpsgALRAPSPASFVpTPPPSSHGI...SIGP..GASFASpHGTLDPSSPYTMVSPSGRAG.NWPgSPQVSGPSPatrMPGMS..PANPSLHS..PVPDASHSPRAGASSQTMPTNmppprklpqrSWaASIPTiLTHSALNIL.LLPS.PTPGLVPSLAGSY......LCSPLERflGSVImrrHLQ.RIIQQE...TLQLINSNePGVIMFKTDALKCRVALSPKTNQTLQ.LKVTPENAGqwkPdeLQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHIM....KLELFPDQATQLKWNVQFCLTIPPSappiapPGtpavvLKSKMLFFL...QLTQKTSV.....PPQePV..SIIVPIIYDMaSGTTQQADIPRQQNSSVAAPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     180|     209|       2
---------------------------------------------------------------------------
  180-  209 (48.89/32.90)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  210-  243 (45.75/30.31)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.16|      28|      32|     443|     474|       3
---------------------------------------------------------------------------
  443-  474 (43.46/33.40)	IKHLPT..ICSETLQLSNYSTHpignLSKNKLFI
  476-  505 (45.71/25.09)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      19|      32|      13|      31|       4
---------------------------------------------------------------------------
   13-   31 (31.17/22.23)	VERKIEIVQFASRTRQLFV
   46-   64 (32.43/23.44)	VEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      14|      29|     102|     115|       5
---------------------------------------------------------------------------
  102-  115 (26.30/15.92)	RLPTCIRDKII....PPD
  128-  145 (19.19/ 9.21)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      29|     293|     304|      10
---------------------------------------------------------------------------
  293-  304 (20.47/10.71)	IKIDENDVSKPL
  324-  335 (20.28/10.55)	MKIDHLSIEKLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18152 with Med14 domain of Kingdom Metazoa
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