<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18120

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTLLINNIASIAFRVYEPPSDLSQSFASVALDIENTLREDEHVVFFDAARHGIWHFRIIGKQGHDDVTSHGIDTTLELCGQTLVVGEEGTLEPASLQRTRPQQQQQQQGIQTPTISTSSASALDQSQRNAFASVSQGAAPSSQDQDAKAADASGVDSKAGATPNKTVYENFITAVLLSISSTFCNRSGAVPLNFRTVLLPPAPLESDGPHDADVERCPVLATLKAYLTTTGALVISFGVSHCKGLTPVADLVPMSPALPGTPILAAPFGVMALTQFSSAGEAGTASLAQTPNTQALSLRGGPDVHDSLWKQACLEVLKLRGVASASLSDCSWLNLLVPKHKLQDAYDETKRAQAVGSGISMPWPGPLCFRKRAVEVSLTSRVGDTILSGHEENHDPLGSARGWFNTATERHEKVSKRKAERAAASKDAASAESRAPKPSAPSPVDIRRPSTATASAIYPTPPDGVQHPNGVTPSFDGTLSSPGNPLSVAPATETDPAAPSTSAMGDAFDVDGDFNESKRQRSESNLLGEAEHMFGDMGEDMFGDNDITEADFNFFDEQQPGDSDFDMSMDDTGATNNANDEAPKADEESLRAANEAKPDAVSERDTVIFAKPELKHARSSRNDAVGQRGRDTPSGATKRESSPFDPHTVFKRVRASLAATERGSSTSSPESTRMTRIFESMSFDATLPMINKKYEQGGQFDYKQIARTEKPRLEPGMLPETDYLKRHGRQGRRLRDRRPHTGSLVRTLTGIEPPTSHPSPIKVEGSLSDDDGSSVGSDQDDSSYTTEEPTSPLKSSVKLVALDDDAMSNVTSLREVEPLEEPNQHLAVELPGLFKPEIPELPLTLLFSDPEPLSLDLSLGDDDLIQVAQILTEQAAVGSLNICNTQEGTSPHVATNLGCQSLSVDARNAMRILRDFVPSLLRGTGATSLKGFLDIPDIPLLGQPSRLQPRPIPGRDPNAEPLRPSNLYQIPGPHLEVRRSELKLSVLPSAVPFWESLGLAPSPGSKDVRAICVFPGWNGMVDNVKTFLCRVKSVYEMLKLGSLESMPSSADMDDGILPYEVDRISTSPGATMTGHGSALIEIMETLRGAISNLTVTETNVVVYFVYSPNNPGTIVEACIAFLRFFDSYRKALASQREAAPNELVLQLVSADMLSSAVSVVVTPAPELVKLCMETYDRCTLFGGPMPAPAIKLEQPLPRIIDFKLTVSPSASLIRENSCIHVAYAPSADGRWITAAWTDDRGSQQETASYCLGRKGRPQSRTMNEVAHEIWESTLDLISVWKVHWRIVITKCGPMDQQEVDFWVDLARTEIKASVAMILMTVDTNPSLQLIPPAVKLPQPSAPLYTTPVSTPQASIVSPEQSGTPVTPARDANTTAATPGADGAGETDSDAVLSDMADQTWGAVVGHRLNNSSSVLEVHPALVSGYLIKRTGTRMEDAPVLMEVNLVHTDASPRAHEPLLREMLSYFRGLGTLARARGVVQRETDVRPWHVAAAEKAVRAMYLLL
Length1512
PositionKinase
OrganismTolypocladium capitatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.05
Grand average of hydropathy-0.314
Instability index45.92
Isoelectric point5.05
Molecular weight163002.27
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18120
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.90|      15|      18|     447|     463|       1
---------------------------------------------------------------------------
  449-  463 (27.42/16.58)	PSPVD.IRRPSTATAS
  467-  482 (26.49/ 9.35)	PTPPDgVQHPNGVTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.17|      16|      18|    1354|    1370|       2
---------------------------------------------------------------------------
 1354- 1370 (25.76/15.66)	TPVsTP....QASIVSPEQSG
 1371- 1390 (23.41/ 9.49)	TPV.TPardaNTTAATPGADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.36|      16|      18|     537|     554|       3
---------------------------------------------------------------------------
  537-  554 (27.60/24.58)	EAEHMFGDmgEDMFGDND
  557-  572 (31.77/20.06)	EADFNFFD..EQQPGDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.40|      16|      20|     302|     317|       4
---------------------------------------------------------------------------
  302-  317 (30.30/16.26)	QALSLRG..GPDVHDSLW
  323-  340 (24.10/11.44)	EVLKLRGvaSASLSDCSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.09|      20|      20|     129|     148|       5
---------------------------------------------------------------------------
  129-  148 (34.92/20.37)	SALDQSQRNAFAS...VSQGAAP
  149-  171 (29.17/15.74)	SSQDQDAKAADASgvdSKAGATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.23|      25|      32|     775|     806|       6
---------------------------------------------------------------------------
  775-  801 (40.63/22.31)	LSDDDGSSVGSDQDdsSYTTEEPTSPL
  810-  834 (40.60/22.71)	LDDDAMSNVTSLRE..VEPLEEPNQHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      17|      18|    1413|    1429|       8
---------------------------------------------------------------------------
 1413- 1429 (28.42/17.91)	GHRLNNSSSVLEVHPAL
 1432- 1448 (28.86/18.31)	GYLIKRTGTRMEDAPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      11|      20|     644|     654|       9
---------------------------------------------------------------------------
  644-  654 (20.19/11.41)	ATKRESSPFDP
  667-  677 (18.21/ 9.46)	ATERGSSTSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.40|      16|      18|     386|     403|      10
---------------------------------------------------------------------------
  386-  403 (22.99/18.74)	LTSRVGdtILSGHEENHD
  405-  420 (29.41/17.01)	LGSARG..WFNTATERHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.12|      18|      19|     703|     721|      11
---------------------------------------------------------------------------
  702-  720 (28.35/26.63)	YEQG..GQFDY.KQIARTEKpR
  721-  741 (25.77/16.95)	LEPGmlPETDYlKRHGRQGR.R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.76|      17|      23|     598|     614|      12
---------------------------------------------------------------------------
  598-  614 (29.19/19.79)	LRAANEAKPDAVSE..RDT
  622-  640 (25.57/16.28)	LKHARSSRNDAVGQrgRDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.94|      23|     625|     104|     127|      13
---------------------------------------------------------------------------
  104-  127 (37.39/25.75)	LQRTRPQQQ...QQQQGIQTPTiSTSS
  742-  767 (38.54/22.00)	LRDRRPHTGslvRTLTGIEPPT.SHPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.06|      14|      20|     256|     269|      15
---------------------------------------------------------------------------
  256-  269 (25.67/12.60)	VADLVPMSPA.LPGT
  278-  292 (19.39/ 7.81)	VMALTQFSSAgEAGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.18|     103|     141|     848|     955|      17
---------------------------------------------------------------------------
  848-  955 (161.78/102.13)	ELPLTLLFSD.P..EPLSLDLSLGDDDLIQVAQILTEQAAVGSLN..ICNTQegtSPHVATNLGC.QSLSVDARNAMRILRDFVPSLLRGTGATsLKG....FLDIPDiPLLGQPSRL
  989- 1101 (155.39/84.79)	ELKLSVLPSAvPfwESLGLAPSPGSKDVRAICVFPGWNGMVDNVKtfLCRVK...SVYEMLKLGSlESMPSSADMDDGILPYEVDRISTSPGAT.MTGhgsaLIEIME.TLRGAISNL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18120 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATLPMINKKYEQGGQFDYKQIARTEKPRLEPGMLPETDYLKRHGRQGRRLRDRRPHTGSLVRTLTGIEPPTSHPSPIKVEGSLSDDDGSSVGSDQDDSSYTTEEPTSPLKSSVKLVA
2) NAFASVSQGAAPSSQDQDAKAADASGVDSKAG
3) SAPLYTTPVSTPQASIVSPEQSGTPVTPARDANTTAATPGADGAGETDSDAVL
4) SRVGDTILSGHEENHDPLGSARGWFNTATERHEKVSKRKAERAAASKDAASAESRAPKPSAPSPVDIRRPSTATASAIYPTPPDGVQHPNGVTPSFDGTLSSPGNPLSVAPATETDPAAPSTSAMGDAFDVDGDFNESKRQRSESNLLGEAEHMFGDMGEDMFGDNDITEADFNFFDEQQPGDSDFDMSMDDTGATNNANDEAPKADEESLRAANEAKPDAVSERDTVIFAKPELKHARSSRNDAVGQRGRDTPSGATKRESSPFDPHTVFKRVRASLAATERGSSTSSPESTRMTRIFESMS
5) TLEPASLQRTRPQQQQQQQGIQTPTISTSSASA
693
137
1348
388
98
809
168
1400
690
130










Molecular Recognition Features






MoRF SequenceStartStop




1) EDMFGDNDITEADFNFFDEQ
2) GEAEHMFGDM
3) SKRKAERA
4) VFKRVR
547
536
423
657
566
545
430
662