<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18120

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTLLINNIASIAFRVYEPPSDLSQSFASVALDIENTLREDEHVVFFDAARHGIWHFRIIGKQGHDDVTSHGIDTTLELCGQTLVVGEEGTLEPASLQRTRPQQQQQQQGIQTPTISTSSASALDQSQRNAFASVSQGAAPSSQDQDAKAADASGVDSKAGATPNKTVYENFITAVLLSISSTFCNRSGAVPLNFRTVLLPPAPLESDGPHDADVERCPVLATLKAYLTTTGALVISFGVSHCKGLTPVADLVPMSPALPGTPILAAPFGVMALTQFSSAGEAGTASLAQTPNTQALSLRGGPDVHDSLWKQACLEVLKLRGVASASLSDCSWLNLLVPKHKLQDAYDETKRAQAVGSGISMPWPGPLCFRKRAVEVSLTSRVGDTILSGHEENHDPLGSARGWFNTATERHEKVSKRKAERAAASKDAASAESRAPKPSAPSPVDIRRPSTATASAIYPTPPDGVQHPNGVTPSFDGTLSSPGNPLSVAPATETDPAAPSTSAMGDAFDVDGDFNESKRQRSESNLLGEAEHMFGDMGEDMFGDNDITEADFNFFDEQQPGDSDFDMSMDDTGATNNANDEAPKADEESLRAANEAKPDAVSERDTVIFAKPELKHARSSRNDAVGQRGRDTPSGATKRESSPFDPHTVFKRVRASLAATERGSSTSSPESTRMTRIFESMSFDATLPMINKKYEQGGQFDYKQIARTEKPRLEPGMLPETDYLKRHGRQGRRLRDRRPHTGSLVRTLTGIEPPTSHPSPIKVEGSLSDDDGSSVGSDQDDSSYTTEEPTSPLKSSVKLVALDDDAMSNVTSLREVEPLEEPNQHLAVELPGLFKPEIPELPLTLLFSDPEPLSLDLSLGDDDLIQVAQILTEQAAVGSLNICNTQEGTSPHVATNLGCQSLSVDARNAMRILRDFVPSLLRGTGATSLKGFLDIPDIPLLGQPSRLQPRPIPGRDPNAEPLRPSNLYQIPGPHLEVRRSELKLSVLPSAVPFWESLGLAPSPGSKDVRAICVFPGWNGMVDNVKTFLCRVKSVYEMLKLGSLESMPSSADMDDGILPYEVDRISTSPGATMTGHGSALIEIMETLRGAISNLTVTETNVVVYFVYSPNNPGTIVEACIAFLRFFDSYRKALASQREAAPNELVLQLVSADMLSSAVSVVVTPAPELVKLCMETYDRCTLFGGPMPAPAIKLEQPLPRIIDFKLTVSPSASLIRENSCIHVAYAPSADGRWITAAWTDDRGSQQETASYCLGRKGRPQSRTMNEVAHEIWESTLDLISVWKVHWRIVITKCGPMDQQEVDFWVDLARTEIKASVAMILMTVDTNPSLQLIPPAVKLPQPSAPLYTTPVSTPQASIVSPEQSGTPVTPARDANTTAATPGADGAGETDSDAVLSDMADQTWGAVVGHRLNNSSSVLEVHPALVSGYLIKRTGTRMEDAPVLMEVNLVHTDASPRAHEPLLREMLSYFRGLGTLARARGVVQRETDVRPWHVAAAEKAVRAMYLLL
Length1512
PositionKinase
OrganismTolypocladium capitatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.05
Grand average of hydropathy-0.314
Instability index45.92
Isoelectric point5.05
Molecular weight163002.27
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18120
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.90|      15|      18|     447|     463|       1
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  449-  463 (27.42/16.58)	PSPVD.IRRPSTATAS
  467-  482 (26.49/ 9.35)	PTPPDgVQHPNGVTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.17|      16|      18|    1354|    1370|       2
---------------------------------------------------------------------------
 1354- 1370 (25.76/15.66)	TPVsTP....QASIVSPEQSG
 1371- 1390 (23.41/ 9.49)	TPV.TPardaNTTAATPGADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.36|      16|      18|     537|     554|       3
---------------------------------------------------------------------------
  537-  554 (27.60/24.58)	EAEHMFGDmgEDMFGDND
  557-  572 (31.77/20.06)	EADFNFFD..EQQPGDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.40|      16|      20|     302|     317|       4
---------------------------------------------------------------------------
  302-  317 (30.30/16.26)	QALSLRG..GPDVHDSLW
  323-  340 (24.10/11.44)	EVLKLRGvaSASLSDCSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.09|      20|      20|     129|     148|       5
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  129-  148 (34.92/20.37)	SALDQSQRNAFAS...VSQGAAP
  149-  171 (29.17/15.74)	SSQDQDAKAADASgvdSKAGATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.23|      25|      32|     775|     806|       6
---------------------------------------------------------------------------
  775-  801 (40.63/22.31)	LSDDDGSSVGSDQDdsSYTTEEPTSPL
  810-  834 (40.60/22.71)	LDDDAMSNVTSLRE..VEPLEEPNQHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      17|      18|    1413|    1429|       8
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 1413- 1429 (28.42/17.91)	GHRLNNSSSVLEVHPAL
 1432- 1448 (28.86/18.31)	GYLIKRTGTRMEDAPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      11|      20|     644|     654|       9
---------------------------------------------------------------------------
  644-  654 (20.19/11.41)	ATKRESSPFDP
  667-  677 (18.21/ 9.46)	ATERGSSTSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.40|      16|      18|     386|     403|      10
---------------------------------------------------------------------------
  386-  403 (22.99/18.74)	LTSRVGdtILSGHEENHD
  405-  420 (29.41/17.01)	LGSARG..WFNTATERHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.12|      18|      19|     703|     721|      11
---------------------------------------------------------------------------
  702-  720 (28.35/26.63)	YEQG..GQFDY.KQIARTEKpR
  721-  741 (25.77/16.95)	LEPGmlPETDYlKRHGRQGR.R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.76|      17|      23|     598|     614|      12
---------------------------------------------------------------------------
  598-  614 (29.19/19.79)	LRAANEAKPDAVSE..RDT
  622-  640 (25.57/16.28)	LKHARSSRNDAVGQrgRDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.94|      23|     625|     104|     127|      13
---------------------------------------------------------------------------
  104-  127 (37.39/25.75)	LQRTRPQQQ...QQQQGIQTPTiSTSS
  742-  767 (38.54/22.00)	LRDRRPHTGslvRTLTGIEPPT.SHPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.06|      14|      20|     256|     269|      15
---------------------------------------------------------------------------
  256-  269 (25.67/12.60)	VADLVPMSPA.LPGT
  278-  292 (19.39/ 7.81)	VMALTQFSSAgEAGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.18|     103|     141|     848|     955|      17
---------------------------------------------------------------------------
  848-  955 (161.78/102.13)	ELPLTLLFSD.P..EPLSLDLSLGDDDLIQVAQILTEQAAVGSLN..ICNTQegtSPHVATNLGC.QSLSVDARNAMRILRDFVPSLLRGTGATsLKG....FLDIPDiPLLGQPSRL
  989- 1101 (155.39/84.79)	ELKLSVLPSAvPfwESLGLAPSPGSKDVRAICVFPGWNGMVDNVKtfLCRVK...SVYEMLKLGSlESMPSSADMDDGILPYEVDRISTSPGAT.MTGhgsaLIEIME.TLRGAISNL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18120 with Med13 domain of Kingdom Fungi
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