<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18109

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRPPIGVPPRQPQRGLSSTLAVQRPAHHQRSLSQQYLSASTSPVRRDAHSDSTGEPADAAQPRYHVSTPRRGGSKLRLELSNDLTAGPASATASPQGLTPSRVMPMSDAMDLDGMSPALSRASHQDPDNRPMPMPRRRRPQASQLPLGLRPPSAPASAQVKKDARPKPYTVEVPPAAPRFVSTNRHDASNRDIFSKGVFSGHADFSPWSGRHHEDEWSPDAIQKGTWDRPSQNETASARLAIFPALKQKSGLNALSTIFMGVLNQRRYRGQITAPSTFKPPPRVTLTDTKREAWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVSTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVETVVSAFGEADWKARVTYALRLATSLYSEQLLDRDHYLDWIMCGLESSPQSRIPMWILIAQITWADLLRSRKYGRRLAYALLGHLHATYNDPDRDILIQLSSQLSALLKTLLQRNPESFIFPNLWPRYRDTLRASLPADDGLSQGAYHGVNARNARLLAASSTLAPAGRQDLVKLLDAAAQGQNDRDLAAKCWATLDDKSEIVKVVVAWATSLHRPGLARIYVVARLLKSWSTFNVDATQPILDILSDMRPGDKRRSKCVFHLVAELVRARLFSVPQYLQWLIGRGGLHDAADIDPDNGPCASRLLIELPVHCLPESQKAQRSNLLRRAGQYSTTDEANDISNALRCVDDTLGLSPHLANADPQAKCLPLRRLLRRVSSSSKAVQTAIGEHLRDVFTAELLQKVDSIVALSMFHSVRAMLETVQDFFTLSHILKVCSAASDVEVLAACVDTINSHLDVFSALGCADALFGVLTDRLKAVNGEQGVATRPLLAALSSLARRLPRQEQIAKQLVRELAQSDRSNAIDACSPVSDNMAMQAQGAEGEVSEQMDKLLASGNTIDHPTMNRLFRNIIPALEAGWAKGDGSRRVFASLLTRLRIFDAQHFDKLVADWVSHVRTLECRPSLLQLFPLLASLGCLSISTMLHTANAGAAATGEASLDPAATPCGPAVYLQELLRLLITPLPQSASLDSDEMYRFEIQQKSARSEQPKALLLLMRNALVECSGLRDGAPGCAFLLDDAACEHRLLETLGYLVVADSAAVAQAFSVGNLPVGAAALVHKIITKLLMPDDNGVSSETSPETSFDHILGLANELTMPFCLLKLNLDLSAPQPSSGDMDDDGPSRFEAFAKAMDRAIEARNIMWTGMLPCLSQDITRNLSSQAHARFLDLMPSPKSASLDGDAAGEHRVRLAENLLGVLEAVNSGPLPPKSAQLTANLVEKLCDLWEIVASQDEERAGARKEVLGHWLPLLLRFVTLNSMSPEPPQPLNPNQPSAARVPMPPNCEARARIILALCGLLLELDSQPQTTGGALSQQVFDIAVLLVDALPDDLRAQCARLILFMPGGAASTSTTSDLRLYYLFSVPQPTSAENLKLAHRDRASIPYSAAARGISAMYGIGPAAQERLTPFTLRRWEILSEPTPNVGENDTSLSLGLFEAIKIL
Length1539
PositionKinase
OrganismTolypocladium capitatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.06
Grand average of hydropathy-0.185
Instability index48.86
Isoelectric point8.43
Molecular weight168150.33
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18109
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     219.86|      51|      59|    1204|    1257|       1
---------------------------------------------------------------------------
   82-  113 (34.23/10.34)	......LSNDLTAG...............................................P..ASATASPQ..GltPSRVMPMSDAMD.......
 1204- 1239 (55.45/21.40)	........................................................LDLSAPQPSSGDMDDD..G..PSRFEAFAKAMDRAIEARN
 1243- 1301 (71.12/33.59)	TGMLPCLSQDITRNL.................................ssqaharfLDL.MPSPKSASLDGDaaG..EHRVR.LAENLLGVLEAVN
 1302- 1386 (59.06/21.19)	SGPLPPKSAQLTANLveklcdlweivasqdeeragarkevlghwlplllrfvtlnsMSPEPPQP....LNPN..Q..PS...AARVPMPPNCEARA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.08|      37|      59|     726|     762|       2
---------------------------------------------------------------------------
  726-  762 (63.62/38.88)	LRCVDDTLGLSP.HLANA..DPQAKCLPLRRLLRRVSSSS
  782-  821 (51.46/29.95)	LQKVDSIVALSMfHSVRAmlETVQDFFTLSHILKVCSAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     207.86|      52|      61|     364|     416|       3
---------------------------------------------------------------------------
  318-  355 (53.19/32.37)	.........IRGRT.LLDQCLNKNVST.ERAVWLAKCVGAN..EI.......RAFKRK
  364-  416 (84.37/60.57)	GGES...KWVRDWTVFVEQFVETVVSAFGEADWKARVTYAL..RLATSlYSEQLLDRD
  425-  476 (70.30/45.37)	GLESspqSRIPMW.ILIAQI..TWADLLRSRKYGRRLAYALlgHLHAT.YNDP..DRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     281.98|      90|     363|     561|     718|       4
---------------------------------------------------------------------------
  625-  718 (144.12/121.62)	DILSDMRPGDKRRSkcVFHLVAELVRARLFSVPQYLQWLIGRGGLHDAADIDPDNGPCAS....rlLIELPVHCLPESQKAQRSNLLR.RAGQYSTTDE
  991- 1087 (137.85/69.80)	DWVSHVRTLECRPS..LLQLFPLLASLGCLSISTMLHTANAGAAATGEASLDPAATPCGPavylqeLLRLLITPLPQSASLDSDEMYRfEIQQKSARSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.90|      13|      65|     765|     779|       5
---------------------------------------------------------------------------
  765-  779 (16.18/17.97)	VQTaIGEHLrDVFTA
  830-  842 (24.72/14.78)	VDT.INSHL.DVFSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.20|      80|     332|     529|     612|       8
---------------------------------------------------------------------------
  529-  612 (126.49/83.78)	HGVNARNarLLAASSTLA...PagRQDLVKLLDAAAQGQNDRDLAA.KCWATLD...........DKSEIVKVVVAWATSLHRPGLARIY..VVARLLKSW
  864-  960 (113.71/64.93)	QGVATRP..LLAALSSLArrlP..RQEQIAKQLVRELAQSDRSNAIdACSPVSDnmamqaqgaegEVSEQMDKLLASGNTIDHPTMNRLFrnIIPALEAGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.13|      10|      20|      20|      29|       9
---------------------------------------------------------------------------
   20-   29 (18.76/10.63)	STLAVQRPAH
   42-   51 (19.37/11.23)	STSPVRRDAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.63|      15|     160|       4|      19|      10
---------------------------------------------------------------------------
    4-   19 (27.79/18.78)	RP.P..IGVPPRQPqRGLS
  167-  184 (21.84/ 9.07)	RPkPytVEVPPAAP.RFVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.10|      30|     238|     243|     277|      11
---------------------------------------------------------------------------
  243-  277 (43.53/39.44)	AIFPALKQKsglNALSTIFMGVLNqrRYRGQITA..P
  487-  518 (51.58/31.13)	ALLKTLLQR...NPESFIFPNLWP..RYRDTLRAslP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18109 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRPPIGVPPRQPQRGLSSTLAVQRPAHHQRSLSQQYLSASTSPVRRDAHSDSTGEPADAAQPRYHVSTPRRGGSKLRLELSNDLTAGPASATASPQGLTPSRVMPMSDAMDLDGMSPALSRASHQDPDNRPMPMPRRRRPQASQLPLGLRPPSAPASAQVKKDARPKPYTVEVPPAAPRFVSTNRHDASNRDIFSK
1
198










Molecular Recognition Features






MoRF SequenceStartStop




1) KLRLEL
2) LSSTLAVQR
77
18
82
26