<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18108

Description Mediator of RNA polymerase II transcription subunit 5 (Fragment)
SequencePSPLFQHPYSYSSCLLLTIARRIRAAPPAAARSNTSPPWRLIGSSGQLVLTRHSRAVVPNSLVRASVSHAMDGNAQDPRGALRDSTAYWATFIAKCKAKRLDTDRFEEFVQLVYTERPLPPIFIADLFLKPQPSNDVSLDPRMPLYVKVLSRFGYIDAPAILWTMYKYSSLHAQLRLSQNASNMDKDQTRCWRSSSWAEEVMFYHVIKMVVEGSAFRDSRAALVLVKSLCKWMNLFTSASTAFAADVLGEIQSSQVRDEMDVTRAAFTPLLLRLVETPSLVKVISKPVARAVRKELAESLSGFIHTLQPSLGFVERLEIFRSETLARLDPVSKKKQAAANAAMDELLETTVGLENFLVGRPLIDDDALLSYLHNRYQGQTQSSAIDLTLASFDILANTVFRNEGHKDAHLLRSFLINKVPLLLCQLCPPQFSTTSSEFCITEALNQVDTSMFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGETSMSYEPSLQKYSKDKLVQGCLSDPEKIQGLARELDKMDGNVGAVSQALVELMRQLCNSKETMTLKLLCGQLAQRPQDLDILLLFEKLPAILDPLCQLLDNWRYDDDQGEYQPIYEEFGAILLLIFAFAYRYNLTAADIGITSADSCITKILNRAHLSFELDELSGEQKGHIGGWIHGLFDSETGGLGDDLMSSCPPQEFYLLVASIFQNIVVAYTHGYLNDETLKSGIEYVVDTFLLPSLVPAIIFLSDYLWVEQREQKSIIKILQLILLPSSISGEASTMLSSVKNLVAKPLEHSLRTYQKQDPKNQEVEPLLRALKDSLPLSRRTGGAEHNELESWTSSSSTGLAGAVKHTIQGLVQWSMHHGINVMPTSYTHRQMIATCRIVGASRVLRVMLEEIRHQSEAGSASIVYDVVAALICAPDVSNEPPAAGNLLDAAGNVAPTPQRRLKLREVLRSEAQDCRKLQKKDAALAEIVVGLHRRVEAQMVLPQPQALLEASDMPLDLSGGAAGLGDAMAAAAGVQGDGMSVDGVGLDMGLGGVSSDLGLGGPSGSVGGLDSTSDGDLFGGMDTSMDMFNGWDGMDLSGN
Length1084
PositionTail
OrganismTolypocladium capitatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.07
Grand average of hydropathy-0.075
Instability index45.07
Isoelectric point5.41
Molecular weight119128.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18108
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.90|      30|      31|     708|     737|       1
---------------------------------------------------------------------------
  672-  709 (31.23/17.57)	..WIHGLF..DSETGGLGDDlmsscppqefYLLVASIFQNIV
  710-  739 (49.96/32.54)	VAYTHGYL..NDETLKSGIE..........YVVDTFLLPSLV
  742-  770 (29.70/16.35)	IIFLSDYLwvEQREQKSIIK...........ILQLILLPS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.25|      31|      36|    1000|    1035|       2
---------------------------------------------------------------------------
 1004- 1034 (54.96/37.97)	GGAA...GLGDAMAAAAGVQ..GDGMSVDGVGLDMG
 1036- 1071 (47.29/27.13)	GGVSsdlGLGGPSGSVGGLDstSDGDLFGGMDTSMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.13|      16|      36|     429|     444|       3
---------------------------------------------------------------------------
  429-  444 (30.29/19.50)	PQFSTTS.................SEFCITEAL
  450-  482 (20.83/11.23)	SMFPTASlmfdesrsnnpytesvrEEFCTACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.36|      39|      40|     336|     375|       4
---------------------------------------------------------------------------
  336-  375 (60.78/51.83)	QAAAN.AAMDELLETTVGLENfLVGRPLIDDDA..LLSYLHNR
  377-  418 (56.58/42.07)	QGQTQsSAIDLTLASFDILAN.TVFRNEGHKDAhlLRSFLINK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.18|      33|      36|     256|     290|       5
---------------------------------------------------------------------------
  256-  290 (49.67/45.24)	VRDEMDVTRAAFTPLL...LRLVETPSLVKviSKPVAR
  292-  327 (48.52/36.71)	VRKELAESLSGFIHTLqpsLGFVERLEIFR..SETLAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.69|      20|      36|     933|     952|       6
---------------------------------------------------------------------------
  933-  952 (33.63/23.80)	DAA.GNVAPTPQRRLKLREVL
  966-  986 (28.05/18.57)	DAAlAEIVVGLHRRVEAQMVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.38|      20|      27|     581|     602|       8
---------------------------------------------------------------------------
  581-  602 (33.32/20.07)	LFEKLPAILDPLCQLldNWRYD
  611-  630 (35.06/16.00)	IYEEFGAILLLIFAF..AYRYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.48|      54|     152|       9|      66|       9
---------------------------------------------------------------------------
    9-   66 (81.46/64.61)	YSYSScllLTIARRIRAAPPAAARSNTsPPWRLIGSSGQLVLTRHSRAVVPNSLVRAS
  166-  219 (96.02/62.50)	YKYSS...LHAQLRLSQNASNMDKDQT.RCWRSSSWAEEVMFYHVIKMVVEGSAFRDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.92|      13|      19|     784|     796|      10
---------------------------------------------------------------------------
  784-  796 (21.72/13.83)	KNLVAKPLEHSLR
  804-  816 (21.20/13.31)	KNQEVEPLLRALK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18108 with Med5 domain of Kingdom Fungi
Unable to open file!