<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18086
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLQHQIVQSPAMLGLTNPNSPSILNPNPQKLPPSQTHHHQNHHSVAPSAALLTLLPPLPRAQALLSQMATLASKLFEVSPNRSAWVTTFRGSLPTFLSSQTQPHSSSLLESLPSTTKEMISLFTSLQTQIFEAVSELQEIIDLQDAKKKIDGEIRSKDSALLAFANKLKDAERELDILVDDYSDYRRSIKRLKSEDGSNDDSLTTSNVSSQLKISDILSYAHRISYTTFAPPEFGAGTAPLRGAMPPAPQDEQMRASQLYNFADLDIGLPKAVETKEKAVEAIIEPFQPVDTNPLANLPAIQGMLPPNFAVPPGWKPGMPVQLPIDIPIMPPPGWKPGDPVALPHIDSLPVPRFEEQKLHPQIPQPKQPEIIQVQHVNLDLGGSDSSDYSSDEASSDDED |
Length | 400 |
Position | Middle |
Organism | Trifolium pratense (Red clover) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade>
NPAAA clade> Hologalegina> IRL clade> Trifolieae> Trifolium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.400 |
Instability index | 62.61 |
Isoelectric point | 5.03 |
Molecular weight | 43782.00 |
Publications | PubMed=24500806
PubMed=28382043
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18086
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.71| 13| 19| 306| 324| 1
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306- 324 (26.56/21.96) PPnfavppGWKPGMPVQLP
332- 344 (32.15/13.62) PP......GWKPGDPVALP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 150.22| 31| 32| 47| 77| 2
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9- 44 (36.46/17.31) ...SPAMLGLTNPnspsiLnPNPQKLPPSQTHHHQNHHS
47- 77 (50.13/26.67) P..SAALLTLLPP.....L.PRAQALLSQMATLASKLFE
80- 110 (42.31/21.32) PnrSAWVTTFRGS.....L.P..TFLSSQTQPHSSSLLE
112- 132 (21.32/ 6.94) ..........LP........STTKEMISLFTSLQTQIFE
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