<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18069

Description Mediator of RNA polymerase II transcription subunit 15a-like protein
SequenceMMMMMMMMMTHFNISDLMDSNNWGPNQGTEPPGDTGDWRTQLQPDSRQRIVNKIMDTLRKHLPVSGSDGLHELRMIAQRFEDKIYTAATSQSDYLRKISMKMLTMENKSQNTTANNMQSNEGGPSNNPPDQGLVLQSQVLNQGQQQPRQQLLSQTIQNNGAPQPNFPSVSNLSQIPNQKIGQNSNTHQPGQNSASNAIGQNSNVQGMFPGSQRQMLGRQQVVPQQQQQQVVHQQQPHNPQQILYQQQLLKRKFQLTQQQQNLLQPNQLQSSQQSVMQTSSAMQPSSMMQTTLSSSLPQNQQSNNVQQSTQSRLQQHSQIIRQQQNSIAHQQQTPMTQQPNLHVQQQQQLVGPQSNTTNGQHAQMLGPQSNVDDTQKSQRLHPQQNNLMNLQQRQQQQQLLNQQNNLTNINQQSGNNVPGLQQQQLFGTESGNQGIQTSNHSAHMLQQSKVSMQQQLQQNASKLLPSQSQQSQTQASQQQLMSQIHNHPAQMQQPNPLQRDMQQKLQASGSLLQQQSVLDQQKQLYQSQRGLPETSTTSVDSTIQTAQPSGADGQEEVYQKLQTLKENYLSDINEIYQKVSLKLQQHHSIPRQSEPDQVEKIRQYKIMVERLIAFLQLPKQKITPAIKEKFGTYEKQLVSTINSVRPRRGISSLQSGQLPPTHMPSMPQSQSQVTPVQSRENQMNSQMQPSNLQGSAATIQQNNVASLHHNSMSGLATTQQNMLNTIQPSNNLDSGQGNSVNSLQQVPISSRQQNTVSTPQHTNINSLQSQGGVNVIQPNLNTHQSGSTMFQHQQEQKMLQNHQLKQQYQQRQLMQRQQQLHQPAKQQLSGQLQTHQMPQINQMNDINDMKMRQGIGVKPGVFQQHLNSGQNSAYSHQQSKQGSPFQVSSPQLFQAASPQIPQHSSPQIDQQTHLQSLTKVATPLQSSNSPFGVPTPSPPMALSPMLGDSEKPIPGVSSSNAANVGQHTGGAAAPAQSLAIGTPGISASPLLAEFSGPDAYCNTLAAASGKSTAEKPIDRLIRAVQSMSTETLTAAVNDISSVVSMSDMIAGAAPGNGSRAAVGEDLVSMTNCRLQARNFITQDGTSGIRKIKRYTSARPLNVVSSAGSKNDSTNQLSASEASQQESTATSNVKKPKAEVNHALLEEIQQINWRLIDTVVDISDENVGSTAVSAAEMAEGTVVKCSFVPVALSPTLKSQYASLQSPIQPLRLLVPPNYPNCSPIFLDKFPVKSREGNEDLSEKAKSKFSTSLRNLSHPMSLKDVAKTWDTSARGVISEYAQQFGGGTFSSKYGAWEYGTWEDILAA
Length1305
PositionTail
OrganismTrifolium pratense (Red clover)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Trifolium.
Aromaticity0.03
Grand average of hydropathy-0.804
Instability index61.97
Isoelectric point9.37
Molecular weight144009.89
Publications
PubMed=24500806
PubMed=28382043

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18069
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     860.30|      98|      98|     149|     246|       1
---------------------------------------------------------------------------
   75-  143 (60.66/10.27)	MiaQRFED....KIY..TA.AT..SQSD..YL..........................RKISmkmltmENKSQN.TTA...NNMQSN.EGGPS...N.N......P................P...........DQGL...VL.Q..........SQVLNQG
  149-  245 (173.68/44.70)	Q..QLLSQ....TIQ..NN.GA..PQPN..FPSVS.NLSQIP...........N....QKIG......QNSNTH.QPG...QNSASN.AIGQN...S.NVQG.MFPGSQR.Q.ML.GRQQVVPQQ........QQQQV...VH.QQQPH..NP..QQILYQ.
  246-  334 (88.81/18.85)	Q..QLLKRkfqlTQQ..QQ.NL..LQPN........QL.QSS...........Q....QSVM......QTSSAM.QPSsmmQTTLSS.SLPQNqqsN.NVQ....QSTQS.R.LQ.QHSQII.RQ........QQNSI...AH.QQQ....TP.........
  335-  393 (56.61/ 9.04)	............................................................MT......QQPNLHvQQQ...QQ.....LVGPQ...S.NTT....NGQHA.Q.ML.GPQSNVDDT........QKSQR...LH.PQQ....NN..LMNLQQR
  397-  475 (100.64/22.45)	Q..QLLNQ......Q..NN.....................LT...........N......IN......QQSGNN.VPG...LQQ.QQ.LFGTE...S.GNQG.IQTSNHSaH.ML.QQSKVSMQQ........QLQQN...AS.KLLPS..QS..QQSQTQA
  478-  560 (86.40/18.11)	Q..QLMSQ.....IH..NH.PAqmQQPN...P.....LQRDM...........Q....QKLQ......ASGSLL.Q.....QQSVLD....................QQK.Q.LY.QSQRGLPET........STTSVdstIQ.TAQPSgaDG..QEEVYQK
  562-  636 (52.76/ 7.87)	.......Q....TLK..EN.YL..SDINeiYQKVSlKLQQ.............H....HSIP......RQSEPD.QVE...K.......IRQY...KiMVER.LIAFLQ.....L.PKQKITP..............A...IK.EKFGT..YE..KQ.....
  637-  718 (83.15/17.12)	....LVS.....TI...NS.VR..PRRG..ISSLQ.S........................G......QLPPTH.MP......SMPQ.SQSQV...T.PVQ.....SREN.Q.M...NSQMQPSNlqgsaatiQQNNV...AS.LH..H..NS..MSGLATT
  719-  831 (103.70/23.39)	Q..QNMLN....TIQpsNNlDS..GQGN....SVN.SLQQVPissrqqntvstP....QHTN......INSLQS.QGG...VNVIQP.NLNTH...Q.SGST.MFQHQQE.QkML.QNHQLKQQY........QQRQL...MQrQQQLH..QPakQQLSGQ.
  835-  911 (53.89/ 8.21)	..........................HQ..MPQIN.QMNDIN...........DmkmrQGIG......VKPGVF.QQH...LNSGQNsAYSHQ...Q.SKQGsPFQVSSP.Q.LFqAASPQIPQH........SSPQI...DQ.Q.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.24|      32|     108|     981|    1014|       3
---------------------------------------------------------------------------
  932-  968 (43.61/18.27)	GVPTP.......SPpmalSPM..LGDSEKPiPGVSSSNAA..NVGQ.HT
  981- 1012 (56.68/27.16)	GTPGI.......SA....SPL..LAEFSGP.DAYCNTLAA..ASGK.ST
 1084- 1127 (27.95/ 7.74)	GTSGIrkikrytSA....RPLnvVSSAGSK.NDSTNQLSAseASQQeST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.38|      16|      16|    1227|    1242|       4
---------------------------------------------------------------------------
 1227- 1242 (26.96/18.46)	KFPVKSREGNEDLSEK
 1246- 1261 (27.42/18.92)	KFSTSLRNLSHPMSLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18069 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSNNWGPNQGTEPPGDTGDWRTQLQPDSRQRIVNKIMDTLRKHLPVSGSDGLHEL
2) KQLYQSQRGLPETSTTSVDSTIQTAQPSGADGQEEVY
3) LTQQQQNLLQPNQLQSSQQSVMQTSSAMQPSSMMQTTLSSSLPQNQQSNNVQQSTQSRLQQHSQIIRQQQNSIAHQQQTPMTQQPNLHVQQQQQLVGPQSNTTNGQHAQMLGPQSNVDDTQKSQRLHPQQNNLMNLQQRQQQQQLLNQQNNLTNINQQSGNNVPGLQQQQLFGTESGNQGIQTSNHSAHMLQQSKVSMQQQLQQNASKLLPSQSQQSQTQASQQQLMSQIHNHPAQMQQPNPLQRDMQQKLQ
4) RGISSLQSGQLPPTHMPSMPQSQSQVTPVQSRENQMNSQMQPSNLQGSAATIQQNNVASLHHNSMSGLATTQQNMLNTIQPSNNLDSGQGNSVNSLQQVPISSRQQNTVSTPQHTNINSLQSQGGVNVIQPNLNTHQSGSTMFQHQQEQKMLQNHQLKQQYQQRQLMQRQQQLHQPAKQQLSGQLQTHQMPQINQMNDINDMKMRQGIGVKPGVFQQHLNSGQNSAYSHQQSKQGSPFQVSSPQLFQAASPQIPQHSSPQIDQQTHLQSLTKVATPLQSSNSPFGVPTPSPPMALSPMLGDSEKPIPGVSSSNAANVGQHTGGAAAPAQSLA
5) RKISMKMLTMENKSQNTTANNMQSNEGGPSNNPPDQGLVLQSQVLNQGQQQPRQQLLSQTIQNNGAPQPNFPSVSNLSQIPNQKIGQNSNTHQPGQNSASNAIGQNSNVQGMFPGSQRQMLGRQQVVPQQQQQQVVHQQQPHNPQQILYQQQ
6) VVSSAGSKNDSTNQLSASEASQQESTATSNVKKP
19
522
255
648
96
1102
73
558
506
979
247
1135










Molecular Recognition Features






MoRF SequenceStartStop




NANANA