<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18066

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMQRYHAGSSTSAVNNSTIGGPSARDIGRIDSSSLPTAFPGSRPTMLSFSLDCGATVRRQPPLNLYKLKCDKEPLNSRLGPPDFNPQTPNCPEETLTKEYLLSGYRDTVEGLEEAREILLTQIPHFNKTIVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLSKSSVFPEQRPCPEDFRKKWIEGLSQQHKRLCSLADLVPQYRRKSVLEVLIRNNVPLLRATWFVKVTYLNLVCPGSASVPSGTNDKTQLSCSEFWTKDIIEYLQTLLDDFFSKSTSHSTLHNRDRSPQMPYTASLKHRTNQLLPVSDGEEPSLHFKWWYVVRLLQWHHAEGLLLPSVVIDWVLHQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVRTLTGVALRIIRDPAPGGSDLVDNSRRAYTAAALIEMLRYLILAVPETFVALDCFPLPSSVVSHANNDGNFVPKAIEAAEKIKNSSDVVCIFKSKGLDARYESLAFDRVIACIRKHAENLTKAVSPGYPGDCLAKAAQALDNSLVLGDIREAYKFLFEDLYEGPATDAWVAKVSPCLRNFRTAPPCDIKFTGKKDMSQVHIAVRLLKMKLRNMQTFSRKKNGSTHHGVTYLAKCSSQQNNWNIGSKIKCSSKSMNQGICSSVAFESPGPLHDIIVCWIDQHVVHKGEGLKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDTSVNMVDLERQKRHCRILKQLPGKFIHHALEESEIIEGPLLIEALHVYLNERRLILRGSFSENHDNGSGANNSDVNKKHCSSSTKDRSSTVSIDQRKTVSLNKISYKVEKDDTSVEDLKTVISVLLQLPKSLFNFTTTGLDESQVSVKRPTRCRSKIDVMEATPGCEECRRAKKQKLSEEKSSFVQAHFSVLTDDEDTWWVKKGLKSLEPPKVDQPLKTTKQVTKSRQKTVRKTQSLAQLAASRVEGSQGASTSHICDNKVICPHHRTAMDGDTEKSVDGIRTGPCGDIVSTGRALKRLRFVEKKQITVWLMTLIRQIIEDTEKSIGKVGQFGRPVATVDDKSSIRWKFGEDELSAILYLMDVSDDLVPAIKFLLWLLPKVSSNPNSTINSGRNASMLQRNVDNQVCNVGEAFLLSSLRRYENILATADLIPEILSSIMHRAAAIIASNGRVSGSGALAFARYLLKKYSNVVSVVEWEKNFKTTCDKRLASELESGGRLVNGEFGLPLGVPAGIEDPDDYFRQKISGGRLPSRVGSGMRDVVQRNVEDAFHYLFGKDRKLFAAGAPKVPSLEKWDSGYQIAQQIVMGLMDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPSLAKLPDFSAGNNHPNISLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFDIALATEASNALAGVFAPSKASRNQFQPETHDTSATMSNDVVNSSSKIVLARTTKIAASVSALIVGAVIYGVTSLERMVTILRLKEGLDVIQFVRSSRSNSNGNARSVGAIKVESSVEVHLHWFRLLVGNCRTICEGLVVDLLSEPSIVALSRMQRMLPLSLVFPPAYSIFAFVMWRPFIMNANAVIREDTNQLYQTLTMAINDALKHLPFRDACLRDSQGLYDLMATDTSDLEFATLLELNGSDMRLNSTAFVPLRARLFLNAMIDCKMPQSIYTNDGGNQISGQGESKIHFIENESKLQDKLVDVLEALQPSKFHWQWVELRLLLNELALIEKLQTHDMSLVNAIQLSSPRSEKAAASENENNFIQIIFTRLLVRPDAAPLFSELIHLFGKSLEDSMLLQAKWFLGGQDVLFGRKTIRQRLINIAETKGFSIKPQFSEPWGWCSPCTDPITIKRGKRKIDSFSLEEGEVVEGVDVKRNLKGSSQVFDSEFSTIKQLRGTERAFLELILPSIDQXNQSSDESRYSFASDLIKQLSYIEQQIAAINRGPGKSAPSTPVTEGLTNKVHTRKTTKGGSPGLARRPTSSTDSSPPSPAALRASMSLRIQLMMRFLPILCSDREPSVRNMRHTLASVILRLLGSRIVFEDANILFNATHSSLSKKDGESPFEVASAAFVDSSAQGLFDRLLLILHGLLSSSPPSWLRLKPVSKTSNAPTREFSGFDRELLETLQNHLDSMQLPDSIRWRIQAAMPVLPRSTLYSFSCQPSSVPNSSIVSLQPRIKNSGFNSSSLATPQRSAVPLSRTAAASGKSKQQDTDFEVDPWTLLEDGAGSYPSANKGSGDLVNIHAASWLKGAVRVRRTDLTYIGAVDDDDS
Length2250
PositionKinase
OrganismTrifolium pratense (Red clover)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Trifolium.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index46.18
Isoelectric point9.04
Molecular weight249487.98
Publications
PubMed=24500806
PubMed=28382043

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18066
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.96|     100|     379|    1587|    1701|       1
---------------------------------------------------------------------------
 1587- 1701 (157.18/122.19)	PFRDACLRDSQGL.YDLMatdtsdLEFATLL....ELNGSDMRlNSTAFVPLR...ARL.FLNAMIDCKMPQSIYTNDggnqisgQGESKIH.....FIENESK.LQDKLVDVLEALQPSKfHWQWVELR
 1968- 2082 (143.78/82.43)	PPSPAALRASMSLrIQLM......MRFLPILcsdrEPSVRNMR.HTLASVILRllgSRIvFEDANILFNATHSSLSKK.......DGESPFEvasaaFVDSSAQgLFDRLLLILHGLLSSS.PPSWLRLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.17|      39|     383|     332|     374|       2
---------------------------------------------------------------------------
  332-  374 (62.14/54.35)	QWHHAEGL.LLPSvviDWVLHQLQEKQLLEiWQLLLPIVYGFLE
  715-  754 (64.03/43.14)	QKRHCRILkQLPG...KFIHHALEESEIIE.GPLLIEALHVYLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.17|      26|      29|    1199|    1225|       3
---------------------------------------------------------------------------
 1199- 1225 (45.11/35.23)	SGGRLVN..GEfGLPLGVPAGIEDPDDYF
 1230- 1257 (44.06/28.63)	SGGRLPSrvGS.GMRDVVQRNVEDAFHYL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     362.97|     118|     859|     875|    1002|       4
---------------------------------------------------------------------------
  875- 1002 (176.70/148.87)	RAKKQKLSEEKSSFVQAHFSVLTDDEDTWWVKKGL.....KSLEPPKVDQP..LKTTKQVTKSRqKTVRktQSLAQLAASRVEG..SQGASTSHICDNkviCPHHRTAMDGdtEKSVDGIrTGPCGDIVsTGRALKR
 1730- 1856 (186.27/123.41)	RSEKAAASENENNFIQIIFTRLLVRPDAAPLFSELihlfgKSLEDSMLLQAkwFLGGQDVLFGR.KTIR..QRLINIAETKGFSikPQFSEPWGWCSP...CTDPITIKRG..KRKIDSF.SLEEGEVV.EGVDVKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      19|     383|     233|     258|       8
---------------------------------------------------------------------------
  234-  252 (35.94/30.84)	TYLNLVC.PGSASVPSGTND
  431-  450 (31.03/ 7.97)	TFVALDCfPLPSSVVSHANN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.63|      31|     136|      12|      42|      10
---------------------------------------------------------------------------
   12-   42 (54.27/35.35)	AVNNSTIGGPSARDI.G.RIDSSSL..PTAFPGSR
  143-  177 (38.36/22.45)	AINESRVQKRKAGQVyGvALSGSQLskSSVFPEQR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18066 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NRGPGKSAPSTPVTEGLTNKVHTRKTTKGGSPGLARRPTSSTDSSPPSPA
2) PPKVDQPLKTTKQVTKSRQKTVRKTQSLAQLAASRV
1923
914
1972
949










Molecular Recognition Features






MoRF SequenceStartStop




1) GLKIIYWLDF
318
327