<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18066

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMQRYHAGSSTSAVNNSTIGGPSARDIGRIDSSSLPTAFPGSRPTMLSFSLDCGATVRRQPPLNLYKLKCDKEPLNSRLGPPDFNPQTPNCPEETLTKEYLLSGYRDTVEGLEEAREILLTQIPHFNKTIVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLSKSSVFPEQRPCPEDFRKKWIEGLSQQHKRLCSLADLVPQYRRKSVLEVLIRNNVPLLRATWFVKVTYLNLVCPGSASVPSGTNDKTQLSCSEFWTKDIIEYLQTLLDDFFSKSTSHSTLHNRDRSPQMPYTASLKHRTNQLLPVSDGEEPSLHFKWWYVVRLLQWHHAEGLLLPSVVIDWVLHQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVRTLTGVALRIIRDPAPGGSDLVDNSRRAYTAAALIEMLRYLILAVPETFVALDCFPLPSSVVSHANNDGNFVPKAIEAAEKIKNSSDVVCIFKSKGLDARYESLAFDRVIACIRKHAENLTKAVSPGYPGDCLAKAAQALDNSLVLGDIREAYKFLFEDLYEGPATDAWVAKVSPCLRNFRTAPPCDIKFTGKKDMSQVHIAVRLLKMKLRNMQTFSRKKNGSTHHGVTYLAKCSSQQNNWNIGSKIKCSSKSMNQGICSSVAFESPGPLHDIIVCWIDQHVVHKGEGLKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDTSVNMVDLERQKRHCRILKQLPGKFIHHALEESEIIEGPLLIEALHVYLNERRLILRGSFSENHDNGSGANNSDVNKKHCSSSTKDRSSTVSIDQRKTVSLNKISYKVEKDDTSVEDLKTVISVLLQLPKSLFNFTTTGLDESQVSVKRPTRCRSKIDVMEATPGCEECRRAKKQKLSEEKSSFVQAHFSVLTDDEDTWWVKKGLKSLEPPKVDQPLKTTKQVTKSRQKTVRKTQSLAQLAASRVEGSQGASTSHICDNKVICPHHRTAMDGDTEKSVDGIRTGPCGDIVSTGRALKRLRFVEKKQITVWLMTLIRQIIEDTEKSIGKVGQFGRPVATVDDKSSIRWKFGEDELSAILYLMDVSDDLVPAIKFLLWLLPKVSSNPNSTINSGRNASMLQRNVDNQVCNVGEAFLLSSLRRYENILATADLIPEILSSIMHRAAAIIASNGRVSGSGALAFARYLLKKYSNVVSVVEWEKNFKTTCDKRLASELESGGRLVNGEFGLPLGVPAGIEDPDDYFRQKISGGRLPSRVGSGMRDVVQRNVEDAFHYLFGKDRKLFAAGAPKVPSLEKWDSGYQIAQQIVMGLMDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPSLAKLPDFSAGNNHPNISLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFDIALATEASNALAGVFAPSKASRNQFQPETHDTSATMSNDVVNSSSKIVLARTTKIAASVSALIVGAVIYGVTSLERMVTILRLKEGLDVIQFVRSSRSNSNGNARSVGAIKVESSVEVHLHWFRLLVGNCRTICEGLVVDLLSEPSIVALSRMQRMLPLSLVFPPAYSIFAFVMWRPFIMNANAVIREDTNQLYQTLTMAINDALKHLPFRDACLRDSQGLYDLMATDTSDLEFATLLELNGSDMRLNSTAFVPLRARLFLNAMIDCKMPQSIYTNDGGNQISGQGESKIHFIENESKLQDKLVDVLEALQPSKFHWQWVELRLLLNELALIEKLQTHDMSLVNAIQLSSPRSEKAAASENENNFIQIIFTRLLVRPDAAPLFSELIHLFGKSLEDSMLLQAKWFLGGQDVLFGRKTIRQRLINIAETKGFSIKPQFSEPWGWCSPCTDPITIKRGKRKIDSFSLEEGEVVEGVDVKRNLKGSSQVFDSEFSTIKQLRGTERAFLELILPSIDQXNQSSDESRYSFASDLIKQLSYIEQQIAAINRGPGKSAPSTPVTEGLTNKVHTRKTTKGGSPGLARRPTSSTDSSPPSPAALRASMSLRIQLMMRFLPILCSDREPSVRNMRHTLASVILRLLGSRIVFEDANILFNATHSSLSKKDGESPFEVASAAFVDSSAQGLFDRLLLILHGLLSSSPPSWLRLKPVSKTSNAPTREFSGFDRELLETLQNHLDSMQLPDSIRWRIQAAMPVLPRSTLYSFSCQPSSVPNSSIVSLQPRIKNSGFNSSSLATPQRSAVPLSRTAAASGKSKQQDTDFEVDPWTLLEDGAGSYPSANKGSGDLVNIHAASWLKGAVRVRRTDLTYIGAVDDDDS
Length2250
PositionKinase
OrganismTrifolium pratense (Red clover)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Trifolium.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index46.18
Isoelectric point9.04
Molecular weight249487.98
Publications
PubMed=24500806
PubMed=28382043

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18066
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.96|     100|     379|    1587|    1701|       1
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 1587- 1701 (157.18/122.19)	PFRDACLRDSQGL.YDLMatdtsdLEFATLL....ELNGSDMRlNSTAFVPLR...ARL.FLNAMIDCKMPQSIYTNDggnqisgQGESKIH.....FIENESK.LQDKLVDVLEALQPSKfHWQWVELR
 1968- 2082 (143.78/82.43)	PPSPAALRASMSLrIQLM......MRFLPILcsdrEPSVRNMR.HTLASVILRllgSRIvFEDANILFNATHSSLSKK.......DGESPFEvasaaFVDSSAQgLFDRLLLILHGLLSSS.PPSWLRLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.17|      39|     383|     332|     374|       2
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  332-  374 (62.14/54.35)	QWHHAEGL.LLPSvviDWVLHQLQEKQLLEiWQLLLPIVYGFLE
  715-  754 (64.03/43.14)	QKRHCRILkQLPG...KFIHHALEESEIIE.GPLLIEALHVYLN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.17|      26|      29|    1199|    1225|       3
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 1199- 1225 (45.11/35.23)	SGGRLVN..GEfGLPLGVPAGIEDPDDYF
 1230- 1257 (44.06/28.63)	SGGRLPSrvGS.GMRDVVQRNVEDAFHYL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     362.97|     118|     859|     875|    1002|       4
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  875- 1002 (176.70/148.87)	RAKKQKLSEEKSSFVQAHFSVLTDDEDTWWVKKGL.....KSLEPPKVDQP..LKTTKQVTKSRqKTVRktQSLAQLAASRVEG..SQGASTSHICDNkviCPHHRTAMDGdtEKSVDGIrTGPCGDIVsTGRALKR
 1730- 1856 (186.27/123.41)	RSEKAAASENENNFIQIIFTRLLVRPDAAPLFSELihlfgKSLEDSMLLQAkwFLGGQDVLFGR.KTIR..QRLINIAETKGFSikPQFSEPWGWCSP...CTDPITIKRG..KRKIDSF.SLEEGEVV.EGVDVKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      19|     383|     233|     258|       8
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  234-  252 (35.94/30.84)	TYLNLVC.PGSASVPSGTND
  431-  450 (31.03/ 7.97)	TFVALDCfPLPSSVVSHANN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.63|      31|     136|      12|      42|      10
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   12-   42 (54.27/35.35)	AVNNSTIGGPSARDI.G.RIDSSSL..PTAFPGSR
  143-  177 (38.36/22.45)	AINESRVQKRKAGQVyGvALSGSQLskSSVFPEQR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18066 with Med12 domain of Kingdom Viridiplantae
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