<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18064

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMATSELGQQTVELSTLVSRTAQDSYNSLKELVDKCRSTELSDTDKKISMLKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIEILLSGSYERLPKCIEDVGSQYALTEDKQKPALKKLDMLVRSKLLEVSLPKEISDIKVSDGTATVRVDGEFQVLLTLGYRGHMSLWRILHLELLVGEKNKPVKLEEFRRHVLGDDLERRMAAAENPFSILYSVLHELCVTLVMDTVIRQVQTLRQGRWKDAIRFEIISDGGTGHGASSSSVQNPDGESDSSGPRTPGLKIIYWLDFDKNAGTSDSGACPYIKIEPGSDLQIKCTHSIFVIDPLTGKEAEFFLDQNCIDVEWLILRAICCNRYTRLLEIKRELVKNVQVCRTADDVVLQSCIGEPDVEYKQKDDKGCNKDSEGHEVLRVRAYGSSFFTLGISIRNGRFLLQSSQNIVVSSALLECEEALNQGSMTAAEVFLSLRRKSMLHLFASIGRVLGLEVYEHGLNTVKIPKTFLSGSAMLMMGFPDCGSSYFLLMQLDKDFKPLFKMLETQPDPSGKDNLFGDLNQVLRFKKIDIAQMQVLEDEMNLSLVDWEKLHSILPNAAGPNQTSGHDLYSDIRLENSIHIARGHHPSGFSSLVDEVFGLEKGSSAPPFPVQNLSSPLNTSLPSHYGSVPMNVNVTTHYNGSLFSSGSVKGPVQSSSVKGPVQSSSVGSIPTGQGRGVGKKLSASKSEQDLASVKSPHSVDISSATAMDEDTANDALSGSRSSLLSPPRLTSSRMSAPSSRPNGPPVESFKTAGSSSCATTPVSQGQECTANFSTSEDVISEHDKSSRKRTASDMLNLIPSLQGVVKNQGICKRRKISDSRDSQLSLPQGSITPEMIPKAGGCSYGSLIAEANKGNAPSSIYVAALLHVVRHCSLCIKHARLTSQMDALEISYVEEVGLRSASSNVWFRLPFARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGGSNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEEDSMKKLVADIQRLANARTFSIGMRKLLGVRADEKSEELLTSSDVKISGAKTASDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAATLSSLPKQAGYISSQGLLLGSSTSTANIGQPASGVGANTGITNQTLSMLAAAGRGGPGIVPSSLLPFDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRPSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLTSSNSPNPNPGTQLISANVNRINSVAISRTGNQLANRMGNTLAGSPNLALMTSSPIRRPAGAVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPIPVLREFLKLIAWKKGLSQAQAGDVVSAQKPRIELCLENHAGLNADENSESSSAFRSNIHYDRLHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGEISNVSFLGMSGSHGGRACWSRVDDWEKCKQRVARTVEASASSAADVSQGRLKLVADSVQRNLHLCIQGLRDGSGVTASSGAT
Length1780
PositionTail
OrganismTrifolium pratense (Red clover)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Trifolium.
Aromaticity0.06
Grand average of hydropathy-0.192
Instability index45.86
Isoelectric point7.12
Molecular weight193815.29
Publications
PubMed=24500806
PubMed=28382043

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP18064
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.91|      10|      18|     687|     697|       3
---------------------------------------------------------------------------
  687-  697 (15.72/11.71)	NTSLPSHyGSV
  708-  717 (19.19/ 8.76)	NGSLFSS.GSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.65|      28|      97|     755|     797|       4
---------------------------------------------------------------------------
  755-  797 (39.69/49.40)	SEQDLASVKSphsvdissatamdedTANDAL.....................SGSRSSLLSPPR
  849-  897 (38.97/20.82)	SEHDKSSRKR...............TASDMLnlipslqgvvknqgickrrkiSDSRDSQLSLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.07|      71|     370|    1311|    1406|       7
---------------------------------------------------------------------------
 1333- 1406 (111.42/104.95)	LPCPQFRPFiMEHVAQElNGLDPSFTGQQAGG......LTSSNSPNPNPGTQLISANVNRINsVAISRTGNQLANRMGNT
 1590- 1666 (109.65/55.33)	LPIPVLREF.LKLIAWK.KGLSQAQAGDVVSAqkprieLCLENHAGLNADENSESSSAFRSN.IHYDRLHNSVDFALTVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.56|      37|     370|     215|     251|       8
---------------------------------------------------------------------------
  215-  251 (61.49/46.56)	LVGEKNKPVKLEEF...RRHVLGDDLERRMAAAENPFSIL
  584-  623 (57.07/42.61)	LFGDLNQVLRFKKIdiaQMQVLEDEMNLSLVDWEKLHSIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.68|      10|     285|     132|     149|       9
---------------------------------------------------------------------------
  132-  145 (15.35/22.56)	LPKCiedvGSQYAL
  548-  557 (22.33/ 6.82)	FPDC....GSSYFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.47|      11|     285|     736|     746|      10
---------------------------------------------------------------------------
  719-  729 (19.04/10.13)	GPVQSSSVKGP
  736-  746 (19.43/10.52)	GSIPTGQGRGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.35|      32|     923|     154|     207|      19
---------------------------------------------------------------------------
  175-  207 (53.59/78.85)	SDIKVSDG.TATVRVDgEFQVLLTLGYR....GHMSLW
 1099- 1135 (46.77/22.44)	SDVKISGAkTASDTAD.KLSEQMRRAFRieavGLMSLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.53|      10|     413|    1281|    1290|      21
---------------------------------------------------------------------------
 1281- 1290 (18.95/10.65)	LPFDVSVVLR
 1684- 1693 (20.58/12.20)	LPYCVSVRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      14|      15|     800|     813|      22
---------------------------------------------------------------------------
  800-  813 (25.90/14.46)	SSRMSAPSSRPNGP
  817-  830 (24.68/13.38)	SFKTAGSSSCATTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18064 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSSGSVKGPVQSSSVKGPVQSSSVGSIPTGQGRGVGKKLSASKSEQDLASVKSPHSVDISSATAMDEDTANDALSGSRSSLLSPPRLTSSRMSAPSSRPNGPPVESFKTAGSSSCATTPVSQGQECTANFSTSEDVISEHDKSSRKRTASD
712
862










Molecular Recognition Features






MoRF SequenceStartStop




1) GLKIIYWLDF
318
327