<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17992

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSAANERAALQGAQPMVDLQKLLADVYDNALTDFVQLSTEQGLGDSDRKHRLLLHLHGTRQQLLRSLALVNWKPMKVLAELADHDRVLDLAAGHVRACTELVNALRQQAAGRIMAGAYLNAFDVNTALEVLTTGTYQELPSIILHRPPLFQPPPAPLSRQRSRLAHVTHLIRARLVQVAMPPGLKVVSVGNGTAVLRAEGLYEAKLTLVPSEPLPGLDDAAAAAAGAGAAGAEGGGEEQADAAAGEAGPGAGGLPGWAAEAVAAASGDAAAAAAAAQRWKWRLIHFVLLIGVPFYDPRQPGQILNTCNFHMVLAADNAAYLRWQRKGPGAGAGAAAARSAVSESVATPAPSGLPGAAAAAAAGAGGGGGVSLAAAVKKAEDDEVGAPLAVMHAILTDVAGRLLADELAAAARALAAPGSRWHGHIAVKPSQLLHPGVRIEYWVQAPPLMGKSALPRVGPGEDLRGVRPGPPYLELGMGDSGCVEVQHGPSVLHKPVSMSKLRLDTFRVNVEEVLMRSANMSAQLQLLQIRRELKENLFAAMGLRAPTMRLTSLARQLWCRDGVPLVQPGTEEDGAAAAAAVTGGAAAAAAVGANASAMDIDGGAGVGAGPSGTPGPAAAPAAAAAAAIGAIPPPSSPPPEVTGLLAAAAPPEETAGALVLLNAPVLEYLVTGTTELKIGKHLFSGRLTLRPGQDERDEGSLHHAAEVAASEDSVNAAALSAYNSAPDDSYPASRALKEACAALCRVLQRTHNSTDATHFIQAARRASLHISRLPGGMLEAFTAANPGLAIEARPNEKAATWALQSVPFPPNFPPLELSGAADTPPLRTPQCLAFFLQSRLSLHSPHVLVAVSCNRQLMPIKVLSCIPVPPSTYRLPDHVVAAYMAVSVGAGGGGGGGAHSHSGGAAAGHHHPHHHGGQGGQAALAHSPPHSGGSSPRVLANGGEASHGHSLQHPQHSHSQHHHHHHHHLGGPSPDTSPVRESAPSALGPASSSHGPLFRPSGGGTASITAAGTQLSDAPAGAASGQPSLPGTASPASAAAAGGAGSGPLARRGGGGGGGGGGAVSGSGAGGRPTGQQVAVMLAQQQLSSVVRWCRRRMVWEVLLVQLAAVGAAFEELCSPDAPCQRVRVTRVAGTALPCPIARRPGLAPARVGPACLELELGPDALAGQVTARLWGRFLCSPVCEPVVANRAVGGAGAGGSIGAAAAVAATHGFVLSDEDAPGTVPYAGRGDGGAAGGGGGGRGAPLLCLRRQYCLERGDSALTIVQEVAAVIRMQTLLARLEMTARPAAAATAGTGAGPVLPQRLSVLTRPTAAAAEAVPQPGPRPLQPHNSQEEGVSLAPPAKRLKSEPRVLGDGCDVPMSNGTQPNGGALTAVVDAQAPAQAPAAGAAATTSAATTGTATRGGCGLRWHWPLVGTLTLEHYSCSAAAIRYTPAAGAAGAPGGGGAGEAPAADAATSAIMPPAPLVLHITWAPRDVRGIHGGGGGAAAAAAAPPQTPGAQGGGAAAALFGPLASASVPAGVPAPLANTPSSSTAPHAHQYHHAAHAHHAAAHLHGRGSPLLPPEAVATSSRPVQARAGEPFGTAFCDLVLCTVTCSSGHSLPSEYLHVLEEFAEAGEEGKLLDAVAVAAWPLAGFFTALRPAVLARHGLVLDSDVRPALSQPPYCHRIVCRRRAPNTGHVLMDLLCQAVGRSYIKVSITAVGGAAAAAAAAAAAAAAAGTGEAGLERSSTSGSATPNKQPEPGAAATAGEAGGASQHVLQALKAQAVTRLGPRGVSVSVGGRGAVYTGFGHKPSGVPGPGAPLWLLVPNDCVQAAVELVYSVLN
Length1826
PositionTail
OrganismChlamydomonas reinhardtii (Chlamydomonas smithii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Chlorophyceae> CS clade> Chlamydomonadales> Chlamydomonadaceae> Chlamydomonas.
Aromaticity0.04
Grand average of hydropathy0.042
Instability index48.13
Isoelectric point8.09
Molecular weight183200.51
Publications
PubMed=17932292

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP17992
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     168.26|      34|      39|     903|     936|       1
---------------------------------------------------------------------------
  583-  614 (39.22/ 7.45)	GGAAAAAAVGANASA.MD....IDGGAGVGAGP.SGTP
  615-  641 (36.91/ 6.47)	GPAAAPAAAAAAAIGAIP......PPSS...P..PPEV
  893-  918 (49.64/11.91)	GGGGG.AHS..HSGGA.........AAGHHHPHHHGGQ
  919-  953 (42.49/ 8.85)	GGQAALAHSPPHSGGSSPrvlaNGGEASHGHSLQH...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     165.01|      37|      39|    1167|    1205|       2
---------------------------------------------------------------------------
  247-  286 (37.56/ 6.41)	AG........PGAGG.LPGWAAEAVAAASGDAAA..AAAAaqrwkwrliHF
 1175- 1211 (50.85/11.87)	WGRFLC...SPVCEPVVANRAVGGAGAGGSIGAAaaV..A.........AT
 1212- 1242 (37.85/ 6.20)	HGFVLSdedAPGTVPY.AGRGDGGAAGGGGGG...................
 1465- 1494 (38.75/ 6.89)	APLVLH....ITWAP....RDVRGIHGGGGGAAA..AAAA...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     246.07|      72|     162|    1092|    1166|       3
---------------------------------------------------------------------------
 1041- 1118 (46.67/16.05)	...............AGGA....GS..GPL..................ARRGGGGGGGGGGAV..........sgsgaggrptgqqvavmlaqqqlssvvR.WCRRRMVWEvLlvQLAAVGA.AFEEL.C
 1119- 1166 (69.53/19.71)	SPDAPCQRVRV.TRVAGTA....LP..CPI..................ARRPGLAPARVGPACLELELGPDAL.........................................................
 1287- 1338 (50.08/11.87)	RPAA........AATAGTGagpvLPqrLSV..................LTRPTAAAAEAVP.....QPGP............................................rPLQPHNS.Q.EEG.V
 1339- 1426 (79.79/24.64)	SLAPPAKRLKSePRVLGDG........CDVpmsngtqpnggaltavvdAQAPAQAPAAGAAATTSAATTGTAT...........................RgGCGLRWHWP.L......VGTlTLEHYsC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.00|      50|     134|     190|     243|       4
---------------------------------------------------------------------------
  190-  239 (87.71/22.39)	GNGTAVLRAEGLYEAKLTLVPSEPLPGLDDAAAAAAGAGAAGAEGGGEEQ
  307-  340 (46.30/ 7.22)	CNFHMVLAADN..AAYLRWQRKGPGAGAGAAAARSA..............
  341-  372 (49.59/ 9.89)	...........VSESVATPAPS.GLPG..AAAAAAAGAG..G..GGGVSL
 1733- 1762 (42.41/ 7.26)	............SGS.ATPNKQ.PEPG....AA..ATAGEAGGASQHVLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     704.70|     191|    1129|     384|     580|       6
---------------------------------------------------------------------------
  384-  580 (312.56/143.16)	VGAPLAVMHAILTdvAGRllADELAAAARALAAPGSRWHGHIAVKPSQLLHPGVrIEYWVQaPPLMGKSALP.RVGPGEDLRG...VRPGPPYLELGMGDSGCVEVQHGPSVLHKPVSMSKLRLDTFRVNVEE.................VLMRSANMSAQLQLLQ.IRR......ELKENLFAAMGLRA.P..TMRLTSLARQ...LWCRDGV.......P.LVQ..PG...................................TEEDGAAAAAA
  642-  821 (190.07/75.33)	....................TGLLAA.....AAPPEETAGALV.....LLNAPV.LEYLVT.....GTTEL..KIGK.HLFSGrltLRPGQDERDEG.......SLHHAAEVAASEDSVNAAALSAYNSAPDDsypasralkeacaalcrVLQRTHNSTDATHFIQaARRaslhisRLPGGMLEAFTAAN.P..GLAIEARPNEkaaTWALQSV.......P.FPPnfPP...................................LELSGAA....
 1523- 1711 (202.07/81.38)	VPAPLANTPSSST..APH..AHQYHHAAHAHHA.....AAHLHGRGSPLLP...........PEAVATSSRPvQARAGEPF........GTAFCDLVLCTVTCSSGHSLPS...............EYLHVLE.............................EFAE.AGE......E..GKLLDAVAVAAwPlaGF.FTALRPA...VLARHGLvldsdvrPaLSQ..PPychrivcrrrapntghvlmdllcqavgrsyikvsiTAVGGAAAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.84|      40|     674|     147|     188|      11
---------------------------------------------------------------------------
  147-  188 (63.69/39.10)	PPLFQPPPAPLSRQrSRLA.HVTHLIRARLVQVAMPPgLKVVS
  824-  864 (69.15/34.60)	PPLRTPQCLAFFLQ.SRLSlHSPHVLVAVSCNRQLMP.IKVLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17992 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGGGGGGAHSHSGGAAAGHHHPHHHGGQGGQAALAHSPPHSGGSSPRVLANGGEASHGHSLQHPQHSHSQHHHHHHHHLGGPSPDTSPVRESAPSALGPASSSHGPLFRPSGGGTASITAAGTQLSDAPAGAASGQPSLPGTASPASAAAAGGAGSGPLARRGGGGGGGGGGAVSGSGAGGRPTGQQV
2) GVPAPLANTPSSSTAPHAHQYHHAAHAHHA
3) PVLPQRLSVLTRPTAAAAEAVPQPGPRPLQPHNSQEEGVSLAPPAKRLKSEPRVLGDGCDVPMSNGTQPNGGALTAVVDAQAPAQAPAAGAAATTSAATTGTATR
890
1522
1300
1078
1551
1404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA