<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17881

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRLVMDVKEPQGLGGLKRDGSHLSQSSEGREQKRVASDASRAQLNGGPAPPTNAARIPGTTTNGASQHDGGKATTKAEAGSRDELREAPPPELEHYRDTLVPFGKMVERMAQQTYFDLSEAIESLADVHIDPQAQLTNGVGTQIPQDKSRQSVDKKLRLLNFAQQHKDRFIKALVLSDWARNMDEMATLIDVSMFLRKQDWATHGAADGIQRLKENMIGAKMPNPNIEGALELLSTGQAPWMPDLGYVPPEPLTAQELLDTLSDMDFALSVRLNLHEQLPAHFQNYTIANGRATFIVAGEFEVDLAVADDDPESPFYFIDIRLLFTPASSFNNDRLRNQLEGRMNEVLAINGLEGCDEFLHNFVLTHKLNVIRCQALDLARGKWIDNIDVQAIHRSVVIHYWKGQAGGKNWIELGIASSKATTGAKRKPLPQISCRWFRRGQEVMDHDLAFNFDALSAEDMLDQVIAKHASGRLTNLATGLAALSQGSTVFSQDLETSTADAFDCSLRIVIRGSSAPLNIRIDPIQGVFCVQPQSPATKDIERVLNGEPSANGAAVVRYHFCRQQLGHIESRARTLGLVSVDNVTHRGAATSILRETVVFTTLQRPSWKAVPSATNNHALTLTYDLVRGPSWYLSQIDGSKSALCIEKLEPLQLQSTSPAGPGIKDLLLLERQALRKASESSLKREVGEPAKDCIAQSGASEEQRTFPLMYPPTRFLSGHSKAAARVYEDFGTIDLDVPRPDSDTEGTIWSYRTRLHANVPRKTVQLLHHSLKGKQSIWVGQKGEVQIIIRAGLTRPIKDKLEAKLCAITDLCDHVNVLAQQHFAIVDLRLDSVSFSYAPDLTCRVRLSSMAEGPLLDFGGRRSKSQARTNPHAAISKQLETVFVSSDPFTVMTSIPAAKLADFCQVLRATLPLLECARELESRDPGCSITFHCHNALEYRLVYRPPLPAITLTITHRTREGALSWWVKPSLSNTEDRIRSTLGALFKSKGQGWEGMRTAVLAGAEGLRVFLGQIDDVIRKMEGPPEQESGQVMPQQPPAQQQKTQGQNAAQNRNNQKPGNKQRGQEIVVLD
Length1074
PositionTail
OrganismSphaceloma murrayae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Myriangiales> Elsinoaceae> Sphaceloma.
Aromaticity0.06
Grand average of hydropathy-0.371
Instability index43.69
Isoelectric point7.00
Molecular weight118507.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.68|      19|      21|     932|     950|       1
---------------------------------------------------------------------------
  932-  950 (37.00/18.76)	ITFH.CHNALEYRLVY..RPPL
  953-  974 (23.68/ 9.81)	ITLTiTHRTREGALSWwvKPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.96|      18|      21|    1026|    1046|       2
---------------------------------------------------------------------------
 1026- 1046 (28.51/25.50)	GppeQESGQVMPQQPPAQQQK
 1049- 1066 (32.45/18.82)	G...QNAAQNRNNQKPGNKQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      12|      21|     599|     610|       3
---------------------------------------------------------------------------
  599-  610 (22.70/15.16)	TVVFTTLQRPSW
  623-  634 (23.18/15.65)	TLTYDLVRGPSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.98|      22|      24|     646|     668|       5
---------------------------------------------------------------------------
  646-  668 (35.08/22.73)	LCIEKlEPLQLQSTS....PAGPGIKD
  670-  695 (29.90/14.72)	LLLER.QALRKASESslkrEVGEPAKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      16|      19|     832|     847|       6
---------------------------------------------------------------------------
  832-  847 (28.96/17.78)	RLDSVSFSYAPDLTCR
  849-  864 (28.31/17.21)	RLSSMAEGPLLDFGGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.34|      17|      24|     220|     238|       7
---------------------------------------------------------------------------
  220-  238 (25.86/18.14)	IGAKMPNPniEGALELLST
  247-  263 (31.48/16.16)	LGYVPPEP..LTAQELLDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.31|       9|      23|      41|      51|      10
---------------------------------------------------------------------------
   41-   51 (12.78/11.72)	ASraQLNGGPA
   67-   75 (16.54/ 7.57)	AS..QHDGGKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.75|      56|     203|     272|     344|      11
---------------------------------------------------------------------------
  272-  327 (96.81/62.40)	SVRL.NLHEQLPAHFQNYTIANGRATFIVAGEFEVDLAVADDDPESPFYF.ID.IRLLF
  473-  531 (74.64/44.04)	SGRLtNLATGLAALSQGSTVFSQDLETSTADAFDCSLRIVIRGSSAPLNIrIDpIQGVF
  558-  584 (30.30/33.42)	VVRY.HFCRQQLGHIES......RARTL..GLVSVD.......................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17881 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRKMEGPPEQESGQVMPQQPPAQQQKTQGQNAAQNRNNQKPGNKQRGQEIVVL
2) MPGRLVMDVKEPQGLGGLKRDGSHLSQSSEGREQKRVASDASRAQLNGGPAPPTNAARIPGTTTNGASQHDGGKATTKAEAGSRDELREAPPPELEHYRDTLVP
1021
1
1073
104










Molecular Recognition Features






MoRF SequenceStartStop




1) GREQKRVASDASRAQL
2) MPGRLVMDVKEPQGLGGLKRDGSHLSQS
31
1
46
28