<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17880

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMASPERSPKRQRLSPPGDDAPLTAGTSGADSAYGSTTASQVNGITSHKGEAPTSIPGLSLGGQQTAVHGPSGSRTDDQALKVEDAEHRRTDHERQDTIPSATEDLPLLCSKPHPRSRPHPTQNLISLYGLNTLASTVARRDPATGAKINKLRKSYEGKVKKQDLPGRNKPTHIDGELMGFMEWADEAWHDQRIYGRELENALDPVKGRFWREDGEGGKGKVERAVTLAVGRLPREEDEKWRAALSLDEPAATKAPVKAPGFQGNGRLKPGLLNTAHRASAPASPMSRSAVDRPDRSGKKRRYDDASFEGYEGSWTDEAGYVSGDSRGNKGKRRREFDHPSSASQSAGASDHGHFNSSSGNKVVGVRSS
Length368
PositionHead
OrganismSphaceloma murrayae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Myriangiales> Elsinoaceae> Sphaceloma.
Aromaticity0.05
Grand average of hydropathy-0.990
Instability index48.18
Isoelectric point9.33
Molecular weight39708.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17880
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.22|      26|      26|     208|     233|       1
---------------------------------------------------------------------------
  188-  204 (25.28/11.86)	..WH.....DQRIYG.....RELENALD...P
  208-  233 (44.70/26.42)	RFWR.....EDGEGGKGKVERAVTLAVGRL.P
  238-  269 (35.25/19.33)	EKWRaalslDEPAATKAPVKAPGFQGNGRLkP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.01|      26|      26|      73|      98|       2
---------------------------------------------------------------------------
   73-   98 (44.12/25.40)	SRTDDQALKVEDAEHRRTDHERQDTI
  100-  125 (47.88/28.14)	SATEDLPLLCSKPHPRSRPHPTQNLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.91|      28|      31|     300|     330|       3
---------------------------------------------------------------------------
  300-  329 (47.03/34.02)	RRYDDASFEGYEGSWTDEAGYVSgdSRGNK
  334-  361 (50.88/25.59)	REFDHPSSASQSAGASDHGHFNS..SSGNK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17880 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARRDPATGAKINKLRKSYEGKVKKQDLPGRNKPTHIDGE
2) EKWRAALSLDEPAATKAPVKAPGFQGNGRLKPGLLNTAHRASAPASPMSRSAVDRPDRSGKKRRYDDASFE
3) MASPERSPKRQRLSPPGDDAPLTAGTSGADSAYGSTTASQVNGITSHKGEAPTSIPGLSLGGQQTAVHGPSGSRTDDQALKVEDAEHRRTDHERQDTIPSATEDLPLLCSKPHPRSRPHPTQNLISLY
4) SWTDEAGYVSGDSRGNKGKRRREFDHPSSASQSAGASDHGHFNSSSGNKVVGVRSS
138
238
1
313
176
308
128
368










Molecular Recognition Features






MoRF SequenceStartStop




1) KGKRRREFDHPSSAS
2) KINKLRKSY
329
147
343
155