<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17867

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMFTNVFRIGGLHQMSWFQFLAEGETLSPNFPSRKDRPQQDIAAMQMMRAHMWLQETGYLSSWTISDGKVKLWLFLPGRHDSPNPRVHVAVTGLKALASGLWRAPGECTEIGFALDRALRNRIEKGLQTVSYVRFGDVFIKCLRQSTNELNLRKSLFSCDLMLTTSSDSIFVHILVRRKRVRQLVFSDLQAALSQQRSSLGVGGNSLAVVVAPNGLSGRLTGCSPNDLVTQLYKSKLQAYDASSLPFRVVGSTSAVGTSPVQQCYAEVTLDEFSGNTITNRSSAPGVANTKMHGKSRNAGDRGHVLVYPLDAVLAPMRPLVPTQPLTRRCWFQEWAGTTWLEDWTKEEILPSNRKNGLDDGESREKSSITGIGVNGSVPGHSNGPGMSSNSSGGRSSDSSQGSSDTSSSSDVDGDGLGEIEADGDSLGSKGVGALISKNSDMHIPSTSSQGLDMDIGDMKNSHGAYSQCTKRGRQVKSIAAFDPPSKALKRSSSIGNDVLSLMDGTNSDKKGTSFLGESSGLGGGIIGGGSQLGNPWDQWDNNDTFDMGLGMDIQSDADILAEFRDFGDFFEDDGLGFGEPPDTAESQALMFSLPDYGEVSQTPGTAPLDVSDPLVLPILDFPMLGMDQNTGDLLSDIKPTSSMEVSQAPIEGPSSPSRHSPELNLRLKSEAMLCFASGFEPVDMASVPDVGVSTLRDPYVPASKRNAPKSVQKDLYQYSAAPISYAKPERSDVGKDEQRSTKSPNESGESKRKELTADYIVVSGAHGSKHLNGKLLTSVDEGPDRAAGTTLESNKQSADTSGGGKGPQIPGDPFSAQFPSTVKLKESTKSSIRSPVAVLATELECALLQVMKCLTEDSPPSVSGNSVAASPGIEAARSFPLPSKDGGSDITQVQFDLLAQSASGLPKTQRERQKKVPERIAGFADGDMHDGGSRIAQVGVWRPVGVSKPLRSTNTSRYANSVDFPSRVSNSTSTVDLDMDDVTASGESQRQWRELLEAVPMLAQQASIAVDVSLDGRYGDGPFGWLAAQEVQRQQRKSSADCSQEGGGGMLSFTRCLDQSGMEILDPLSDQISAATASNLLQSDMRVAMANAFGDGAADGPLALVDWCKGFVQSSDGGLCAESTNTEVNSIVTVVGESMTPSQSGGGLKGADIDDIRRNSSSSRAIDSSSLSDQTDPSQRRGLSDDSAVSHADAFGYNETSILALPTPSLLVGYQEDWLKTSCSALHLWEKAPLEPYALAKQVNYHVICLASEPLVTAAADFFQQLSSVYEICRLGSHLPSGTAAGPTGSVGSFSKQSLSGFTLVDVPGVSHSGARGEFHNASNYSLAKAFMGDMAANWNMAEYRKALRKVCKALPLSSGSSANQRELELGPSTVVYVVCPVSDPAGILQTMVDACASLGSAITGADSQRHAPSTSGEDTMPPSLLGFSNPRFCLQLITAETIFKSSGPQASCVDVLKEVAMGVYNKVRRIPRHSQKAEYLQNSGASDARGQFGNTVNPSGLQSNTPMPGLWKDCSGQRGSGHATIATLNSSKNHNIWDGGWKSSTQTDIGTAINQVTDENVRYLYEPAYILARSGAQASAVAFCSDAIRDAVAGCNPRATGNASSGSDVDSTAITERMDADANGVAEQAADLYCCYTWSVDWNWLVSVWTDARGELLDTQLLSLTGIDTTRENCLQILFHQILQQGLQLLNLAVEAGSCRSRGLNITRLGGFYAKESHEWHRVIMAAGADEVRKWPVQIGHPDCHTSSCVGGARSLSDMGLMSDRGLGLGGSGPTSPIPSSSSFGGREKTSHSSKPGVDMSSGLNRRQNQASNQMGPTESTMEMFKWVHSVSLVSVRVDQSLQILSTTEGPAEGTSSSGPSWPAGSGSVLSGVVSVGVNTVKTLAWTGASYSIVPSHVNRPLSTSSVELLLKCPHTEQSPLAQLLQSTGLACPVSTAYTVSAGTSSTINDFAQRSKEDWPSTMSMGLVAHYGTSTTAQDSSGVATSSKGVKPAVVESKEQALEVQRILQTVASDLHALSWLNVGVTCVQRRSPLPFHCEVAQRTQRLLDFLDAEFGYGSTTIS
Length2064
PositionKinase
OrganismPhyscomitrella patens subsp. patens (Moss)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Bryophyta> Bryophytina> Bryopsida> Funariidae> Funariales> Funariaceae> Physcomitrium.
Aromaticity0.06
Grand average of hydropathy-0.315
Instability index47.32
Isoelectric point5.38
Molecular weight219436.36
Publications
PubMed=18079367
PubMed=29237241

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17867
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     244.07|      92|     155|     193|     300|       1
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  197-  298 (135.44/94.58)	SSLGVGGNSLAvvVAPNGLSGR...LTGCSPNDLVTQLyKSKLQAYDASSLP..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................fRVVGSTSAVGTSPVQqcyaevTLDEFSGNTITNRSSAPGV.....ANTKMHGKSRNA
  858-  906 (52.32/16.44)	SPPSVSGNSVA..ASPGIEAARsfpLPSKDGGSDITQV.QFDLLAQSASGLP....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1766- 1816 (56.31/21.76)	....................................................ktqrerqkkvperiagfadgdmhdggsriaqvgvwrpvgvskplrstntsryansvdfpsrvsnststvdldmddvtasgesqrqwrelleavpmlaqqasiavdvsldgrygdgpfgwlaaqevqrqqrkssadcsqeggggmlsftrcldqsgmeildplsdqisaatasnllqsdmrvamanafgdgaadgplalvdwckgfvqssdgglcaestntevnsivtvvgesmtpsqsggglkgadiddirrnssssraidssslsdqtdpsqrrglsddsavshadafgynetsilalptpsllvgyqedwlktscsalhlwekaplepyalakqvnyhviclaseplvtaaadffqqlssvyeicrlgshlpsgtaagptgsvgsfskqslsgftlvdvpgvshsgargefhnasnyslakafmgdmaanwnmaeyrkalrkvckalplssgssanqrelelgpstvvyvvcpvsdpagilqtmvdacaslgsaitgadsqrhapstsgedtmppsllgfsnprfclqlitaetifkssgpqascvdvlkevamgvynkvrriprhsqkaeylqnsgasdargqfgntvnpsglqsntpmpglwkdcsgqrgsghatiatlnssknhniwdggwksstqtdigtainqvtdenvrylyepayilarsgaqasavafcsdairdavagcnpratgnassgsdvdstaitermdadangvaeqaadlyccytwsvdwnwlvsvwtdargelldtqllsltgidttrenclqilfhqilqqglqllnlaveagscrsrglnitrlggfyakeshewhrvimaagadevrkwpvqighpdchtsscvggarslsdmglmsdRGLGLGGSGPTSPIP......SSSSFGGREKTSHSSKPGVdmssgLNRRQNQASNQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.18|      27|      46|     374|     401|       2
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  374-  401 (47.33/22.46)	NGSVPGhSNGPG..MSSNSSGGRSSDSSQG
  422-  450 (45.86/17.94)	DGDSLG.SKGVGalISKNSDMHIPSTSSQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     363.26|     117|     656|    1257|    1401|       3
---------------------------------------------------------------------------
 1023- 1149 (184.69/82.15)	FGWLAA.QEVQRQQRKSSADCSQEGGGGMLSFTRcLDQSGMEILDplsdQISAATASNLLQSDMRVAMANAF.GDGAADGPL.....ALVDWCKGFVQSSdgGLCAESTNTEV..NSIVTVVGESMTPSqsgGGLK
 1263- 1390 (178.57/115.73)	FQQLSSvYEICRLGSHLPSGTAAGPTGSVGSFSK.QSLSGFTLVD..vpGVSHSGARGEFHNASNYSLAKAFmGDMAANWNMaeyrkALRKVCKALPLSS..GSSANQRELELgpSTVVYVVCPVSDPA...GILQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.65|      42|      43|     496|     537|       4
---------------------------------------------------------------------------
  496-  537 (74.38/40.92)	NDVLSLMD.GTNSD.KKGTSFLGESSGLGGGIIGGGSQLG...NPWD
  542-  582 (63.79/33.88)	NDTFDM...GLGMDiQSDADILAEFRDFGDFFEDDGLGFG...EPPD
  590-  632 (52.47/26.35)	..MFSLPDyGEVSQ.TPGTAPLDVSDPLVLPIL.DFPMLGmdqNTGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.26|      47|     236|     698|     755|       5
---------------------------------------------------------------------------
  653-  697 (39.90/12.51)	PSSPS..RHSP...ELNLRLKSEAmlcfasgfePVDMASvP...DVGVSTLRD....
  698-  744 (79.97/54.38)	PYVPASKRNAPKSVQKDLYQYSAA.........PISYAK.PERSDVGKDEQRSTKSP
  789-  835 (73.39/24.82)	TTLESNKQSADTSGGGKGPQIPGD.........PFSAQF.PSTVKLKESTKSSIRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.47|      22|     819|     914|     939|      12
---------------------------------------------------------------------------
  350-  372 (34.93/14.81)	PsNRKNGLDDGESREKSS.ITGIG
  917-  939 (36.54/20.91)	P.ERIAGFADGDMHDGGSrIAQVG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17867 with Med13 domain of Kingdom Viridiplantae
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