<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17864

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEAAPLGSVDFSVLVRKAAEASVSGLKELTETAPELSDTEKKIGLLKYIVKTRQRLLRIAVLTKWCRQIPLVERCQQLSGTLSNHNMSFTQAADFLFYLHETLQQARAPVYDIPTATEILVAGTYNRLPKCIEDLGMQPVLIGEERGGAVKKLNSVLRTRLLDIELPKQITDIKVRGGRVIFKVAGEFEAHLTLGYRGHLSYWRVLKIDILVGEPSGPTQFTDPQAYFLGDELERRMAASDDPLGLMYSILHQFCTALVMDTLFRQIKALLVGRWRDAIKYEKLSETGGGSGPAAGQASAGQGMGGVGELDVESGSAAKVRGSPGLKIMYWLETQRGEVPPSLRIEHGADQQIRCSHSPAVMDSATGMEAEFAVDSSCINVEKLLLRAISCSVHTRLLEVQRGLKGGVHLWQSDNDVVLRRSIPDELESSCEASGEEENMEEAGEEVLCVRAFGVSHMTLGISIRNGRFLLRCPSTVLAAPMVKEMEDALNLGSVQALDIFMKLRTKCLVHYFGLIGKSLNLKLYERGASSVKVPAEGPKLGGDVLIMGFPDCDESFFLCVQLDANFTPLFTLLEAESQSSSGHASLASSAFNISRWMRIDIEAMPILREDTGFSLLEQSGSEAREGCGSMVVKRVEEEGYSKLGIPPVPKGPSRGGGLGLDGGQSGLDQYYGGGGVSHKGNMLTVHSPSNLQGGSPMQHAGSPLQHGNVGYGVNAGPSMVSPSMSSGGYHQGKSLGGSPAFGDGSHRLGRAGMVNGASPHNMTGVSPLRSPMDVRNQMSHRKSPLQSASEQEPGNTRSPVAVGDNATSPIELDDEHITKLIDSISSKTPGSFATTDSPSRQGRHVPQARGGIGAPTSRPLIGKAGSPSGSQLVRASGLLQASSPGWKSTMSPSGPYMTDSGCPGQDVEQQGRLGGGSDKSPAQKSERKRSITDLFNSMSSVQALATSGQRGKRRRTGLEMVPVPAYQAASHVGVGSTAVSQSVLGQSYGLVVRAANQGKASAGAYRAVFQQVEERCRLCIKHARLTRQMDAQGIPYVNEVGLREPSTVLRFRLPGTVPSGDPRTRPSRSDGSYGWQQMGLCLGKPGSEGWEVKVMDAYFSGLWKLQKQSEGVGGTGEQFASPPQDDSHMQCTQEGLVLKYSTVQDDSVTKLVKDLERIWRARAFAVGIRKLLGSREEQKKRGSEQWGKSQGRGGSVGDTGEAEEKKWEIMRRAFRVEAVGLTSVSFTYVGTTPGIMARFVVEWGTSRRGCTMHSPEQLWPHTKFLEDYINGGEVELLLDAIQVTAGPLHALAAAIRPARMAAPASGSSHRPSSPSPGTGMAARAGASPAGSGMSSYGSGGAGQGQGQGQGAGANGSVNYGMNSNGGPGTPQGGMPSNSGRNPGPGLVPSSLLPTDVSVLLRSAYWIRIVYRRDFAIDMRCFAGDQVWLQPAPPPRSGGKGGGGSLPCPQFRTFVVEHVTLGMSSSVDSVGGGATGLSSPSTGANSGARQAGGGVGRAGNSVGSTIAAMQGGSGLGGGSRSTATGSGVGGAISIRAELNPALVGMGDDGGYGGAWVPLAALKKVLRGTLRYLGGLWLFAQFPGILREVLASTLNQNEGALLNHDPEQPALRFFIRGCVFAVSMHRQQLFLQAINVNRYKQQQAAAAHQQVAPVMNMAVELSLGEMQDIGDFFARRVASEPYDASRLASFVTMLTLPVPVLREFLILIQWKVATTRANGGPGGDASGQGASPRPQVELSLESQGGGGGGGEKGNSQQDESGVGGGSQGRSSITHNHHRNTVEFTLTFTFDASSLPQLNVAGGAGWLPQSVALRLAYAYGEGVNRISLSSMDGSHGGRSCWARAEEWERCKEGVMRAVQVAPGEGRGRLRALAEQVQMALQTALTQIGRGAGQ
Length1892
PositionTail
OrganismPhyscomitrella patens subsp. patens (Moss)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Bryophyta> Bryophytina> Bryopsida> Funariidae> Funariales> Funariaceae> Physcomitrium.
Aromaticity0.06
Grand average of hydropathy-0.274
Instability index51.47
Isoelectric point8.77
Molecular weight200459.54
Publications
PubMed=18079367
PubMed=29237241

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP17864
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     240.70|      29|      29|     839|     867|       1
---------------------------------------------------------------------------
  689-  714 (33.59/ 8.60)	SP..........SNlQG.GSPMQHA.....GS..PLQHGN...VG.YG
  725-  754 (35.23/ 9.41)	SM..........SS.GGYHQGKSLGGspaFGD..GSHR.....LGRAG
  839-  867 (47.37/15.42)	SP..........SR.QGRHVPQARGG...IGA..PTSRPL...IGKAG
  868-  896 (30.85/ 7.24)	SP..........S...GSQLVRASGL...LQAssPGWKST...MSPSG
 1317- 1357 (30.25/ 6.94)	SPgtgmaaragaSP.AGSGM.SSYGS...GGA..GQGQGQgqgAGANG
 1358- 1388 (33.62/ 8.61)	SV.....nygmnSN.GGPGTPQ..GG...MPS..NSGR.N...PGPGL
 1480- 1500 (29.78/ 6.71)	SP..........S..TGANS..........GA..RQAGGG...VGRAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.58|      34|     244|    1159|    1232|       3
---------------------------------------------------------------------------
 1191- 1232 (51.39/12.89)	SQGRGGSvgdtGEAEEKKWeimrRAFRVEAVGL.TSVSFTYVG
 1438- 1472 (61.19/24.51)	SGGKGGG....GSLPCPQF....RTFVVEHVTLgMSSSVDSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     396.46|     112|     828|     903|    1020|       4
---------------------------------------------------------------------------
  297-  407 (117.62/51.35)	GQASAGQ........GMGGVGELdVESGSAAKVRGSpGLKIMywletqrgEVPPSLRIEH...GA...DQQI.RCSHSPAVMDS....ATGMEAEFAVDS..SCINVEKlllRA..................iSCSVHTrlLEVQR.GLKG
  416-  544 (132.47/53.16)	NDVVLR.RSIPDELES..SCEA....SGEEENMEEA.GEEVL........CVRAF.GVSHMTLGISIRNGRFLLRCPSTVLAAPmvkeMEDALNLGSVQAldIFMKLRT...KClvhyfGLigkslnlklyerGASSVK..VPAEGpKLGG
  924- 1020 (146.37/61.70)	AQKSERKRSITDLFNSMSSVQAL.ATSGQRGKRRRT.GLEMV........PVPAYQAASHVGVGSTAVSQSVLGQSYGLVVRAA....NQGKASAGAYRA..VFQQVEE...RC.....RL..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     298.10|      76|     828|     213|     293|       6
---------------------------------------------------------------------------
  213-  293 (127.18/81.20)	VG..EPSGPTQFTDPQAYFLGDElERRMAASDDPLGLMYS.ILHQFCTALVMDTLF..R..QIKALLVGRWrdaiKYEKLSETGGGSG
 1042- 1118 (121.16/66.47)	VGlrEPSTVLRFRLPGTVPSGDP.RTRPSRSDGSYGWQQM.GL...CLGKPGSEGWevK..VMDAYFSGLW....KLQKQSEGVGGTG
 1120- 1169 (49.76/21.58)	..........QFASPPQ....D..DSHMQCTQEGLVLKYStVQDDSVTKLVKD.LE..RiwRARAFAVG...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.23|      33|      43|     598|     630|       7
---------------------------------------------------------------------------
  598-  630 (56.33/24.10)	WMRIDIEAMPILREDTGFSLLE..Q...SGSEAREGCG
  642-  676 (55.18/23.45)	YSKLGIPPVPKGPSRGGGLGLDggQ...SGLDQYYGGG
 1697- 1722 (26.73/ 7.49)	.......PVPVLRE...FLILI..QwkvATTRANGGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.27|      24|    1068|     771|     799|       8
---------------------------------------------------------------------------
  771-  796 (38.35/37.11)	RSPMDVRNQmsHRKSPLQSASEQEPG
  809-  832 (39.92/21.70)	TSPIELDDE..HITKLIDSISSKTPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17864 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANGGPGGDASGQGASPRPQVELSLESQGGGGGGGEKGNSQQDESGVGGGSQGRSSITHNHH
2) NMLTVHSPSNLQGGSPMQHAGSPLQHGNVGYGVNAGPSMVSPSMSSGGYHQGKSLGGSPAFGDGSHRLGRAGMVNGASPHNMTGVSPLRSPMDVRNQMSHRKSPLQSASEQEPGNTRSPVAVGDNATSPIELDDEHITKLIDSISSKTPGSFATTDSPSRQGRHVPQARGGIGAPTSRPLIGKAGSPSGSQLVRASGLLQASSPGWKSTMSPSGPYMTDSGCPGQDVEQQGRLGGGSDKSPAQKSERKRSITD
3) RMAAPASGSSHRPSSPSPGTGMAARAGASPAGSGMSSYGSGGAGQGQGQGQGAGANGSVNYGMNSNGGPGTPQGGMPSNSGRNPGPGLVPSSLL
1717
683
1301
1777
935
1394










Molecular Recognition Features






MoRF SequenceStartStop




NANANA