<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17863

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEAAPLGSVDFSVLVRKAAEASVSGLKELTETAPELSDTEKKIGLLKYIVKTRQRLLRIAALTKWCRQIPLVERCQQLSGTLSNHDMSFTQAADFLFYLHETLQQARAPVYDIPSATEILLARTYNRLPKCIEDLGMQPVLIGEEREGAVKKLNSVLRTRLLDIELPKQITDIKVTGGRVIFKVAGEFEAHLTLGYRGHLSYWRVLKIDILVGEPSGPTQFTDPQAYFLGDELERRMAASEDPLGLMYSILHQFCTALVMDTLFRQIKALLVGRWRDAIKYEKLSDTGGGSGAAAGQASAGQGTGGVGELDVESGSAAKVRGSPGLKIMYWLETQRGEVLPSLRIEHGADQQIRCSHSPAVMDSATGMEAEFAVDSSCINVEKLLLRAIACSVHTRLLEVQRGLKGGVHLWQSDNDVVLRRSIPDELESSSEASGEEENVEEAGEEVLCVRAFGVSHMALGISIRNGRFLLRCPSTVLAAPMVKEMEDALNLGSVQALDIFMKLRAKCLVHYFGLIGKSLNLKLYERGASSVKLPADGGLCRLLYERGASSVKMTKEGPKLESAHGGDVLIMGFPDCDESFFLCVQLDANFTPLFTLLEAESQSSSGQASLASSAFNISRWMRIDIEAMSILRDDTGFSLLEQSGSEGREGYGSMVVKRVEEGYSKLGIPPVPKGPIRGGGLGLDGGQSGLDQYYGGGGASHKGNMLAVHSPSNLQGGSPMQHAGSPLQHGNVGYGVNAGPIMVSPSMASGGYHQGKSLGGSPAFGDGSHRLGRAGMVNGASPHNMTGVSPLRSPMDVRNQMSLRKSPLQSASEQEPGSTRSPVAVGDNATSPIELDDEHITKLIDSISSKTSGSFATTDSPSRQGRHVPQARGGIGSPTSRPLIGKAGSPSGSQLVRASGLLQASSPGWKSTMSPSGPYMTDSGCPGQDVEQQGRLGGGSDKSPAQKSKQKRSITDLFNSMSSVQALATGGQRGKRQRTGLEMVPVPAYQAASHVGVGSTAVSQSVLGQSYGHVVRAANQGKASAGAYRAVFQQVEERCRLCIKHARLTRQMDAQGISYVNEVGLREPSTVLRFRLPDTVPSGDPRTRPSRSEGSYGWQQMGLCLGKPGSEGWDVKVQDAYFSGLWKLQKQKEGVGGTGEQFASPPQDDSHMKCTQEGLVLKYSTVLDDSVTKLVKDLERIWRARAFALRIRKLLGSSEEEKKRGSEQGGRSQGRSGSVGDTGEAEEKKWEVMRRAFRVEAVGLTSVSFTYVGTTPGIMARFVVEWGTSRRGCTVHSPEQLWPHTKFLEDYINGGEVELLLDAIQVTAGPLHALAAAIRPARMAAPASGSSHRPSSPSPGTGMAARAGASSAGSGMSLYGSGGAGQGQGQGAGANGSVNYGMNSNGGPGTPQGGMPSNSGRNPGPGLVPSTLLPTDVSVLLRSAYWIRIVYRRDFAIDMRCFAGDQVWLQPAPPPRSGGKGGGGSLPCPQFRTFVVEHVTLGMSSSVDSVGGGAIGSSSPSTGANSGARQAGGGVGRAGNSVGSTIAAMQGGSGLGGGSRSLATGSGVGGAISIRAELNPALVGMGDDGGYGGAWVPLAALKKVLRGTLRYLGGLWLFAQFPGILREVLASTLNQNEGALLNHDPEQPALRFFIRGCVFAVSMHRQQLFLQAINVNRYKQQQQAAAAHQQAAPVMNLAVELSLGEMQDIGDFFARSVASEPYDASRLASFVTMLTLPVPVLREFLILIQWKVATTRANGGPGGDVSGQGASPRPQVELSLESQGGGGGGVEKGNSQQDESGVGGGSQGRSSITHNHHRNTVEFTLTFTFDASSLPQLNVAGGAGWLPQSVALRLAYAYGEGANRISLSSMDGSHGGRSCWARAEEWERCKEGVMRAVQAAPGEGRGRLRVLAEQVQMALQTALTQIGRGAGQQLHVLL
Length1920
PositionTail
OrganismPhyscomitrella patens subsp. patens (Moss)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Bryophyta> Bryophytina> Bryopsida> Funariidae> Funariales> Funariaceae> Physcomitrium.
Aromaticity0.06
Grand average of hydropathy-0.253
Instability index49.90
Isoelectric point8.74
Molecular weight203343.75
Publications
PubMed=18079367
PubMed=29237241

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17863
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.49|      15|      17|     525|     539|       3
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  525-  539 (29.28/17.31)	LYERGASSVKLPADG
  545-  559 (29.21/17.26)	LYERGASSVKMTKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     549.06|      84|      85|     649|     732|       4
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  649-  732 (149.77/48.53)	GRE..G....YGSMVVKRVE...EGYSKLGIP...............PV..PKG...P..IRGGGLGLDGGQSGLDQYYG.......GGGASHKGNMLAV...HSPSNL.QG.....GSPMQ..HAGSPLQHG
  756-  819 (59.02/14.93)	.......................QGKSLGGSP...............AF..GDG...S..HR...LG....RAGM....V.......NGASPH..NMTGVsplRSPMDV.RNqmslrKSPLQ..SA.SEQEPG
  821-  909 (51.94/12.31)	TRSpvA....VGDNATSPIElddEHITKL.IDsissktsgsfattdsPS..RQGrhvP..QARGGIG.....SPTSRPLI.......GKAGSPSGSQL.V...RASGLL.QA.....SSP.............
  910-  976 (57.42/14.34)	.............................GWK...............STmsPSG...PymTDSGCPGQDVEQQG..RLGG.......GSDKSPAQKSKQK...RSITDLfNS.....MSSVQ..ALATGGQRG
  979- 1055 (87.46/25.46)	QRT..G....L.EMVPVPAY...QAASHVG..................V..GST...A..V.........SQSVLGQSYGhvvraanQGKAS.AGAYRAV...FQQVEE.RC.....RLCIK..HARLTRQMD
 1108- 1166 (76.17/21.28)	GKP..G....SEGWDVK.VQ...DAYFS.GLW...............KL..QK.......................QKEG.......VGGT...GEQFA.....SPP...QD.....DSHMKctQEGLVLKYS
 1216- 1283 (67.27/17.98)	GRS..GsvgdTGEAEEKKWE...VMRRAFRVE...............AV..GLT...S..VSFTYVGTTPGI..MARFVV.......EWGTSRRG..CTV...HSPEQL........................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.15|      64|      65|     305|     368|       5
---------------------------------------------------------------------------
  305-  356 (85.04/49.13)	..............................TGGV..GELDVESG..SAAK..VRGS...........................PGLKIMYWLETQRGEVLPS...LRIEHGADQQI..RC
  357-  404 (41.81/19.31)	SHSPAVMDSATG......................meAEFAVDSSciNVEKllLRAI...........................ACSVHTRLLEVQRG.......................
 1333- 1443 (72.29/40.33)	SHRPSSPSPGTGmaaragassagsgmslygSGGA..GQ...GQG..QGAG..ANGSvnygmnsnggpgtpqggmpsnsgrnpgPGLVPSTLLPTDVSVLLRSaywIRIVYRRDFAIdmRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.70|      31|     851|     213|     246|       8
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  215-  246 (53.35/37.67)	EPSGPTQFTDPQAYFLGDElERRMAASEDPLG
 1069- 1099 (57.36/30.05)	EPSTVLRFRLPDTVPSGDP.RTRPSRSEGSYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.73|      33|     249|    1468|    1502|       9
---------------------------------------------------------------------------
 1444- 1467 (36.12/13.97)	.......FAGD.QVWLQPAPPPRSGGKGG..GG.S..
 1469- 1501 (57.33/29.75)	PCPQFRTFVVE.HVTLGMSSSVDSVGGGA..IG.SSS
 1719- 1753 (40.64/14.31)	PVPVLREFLILiQ.W.KVATTRANGGPGGdvSGqGAS
 1754- 1771 (30.65/10.41)	PRP.........QVEL....SLESQGGGG..GG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.68|      15|      18|    1573|    1588|      10
---------------------------------------------------------------------------
 1573- 1588 (23.24/15.87)	Y.GGAWVpLAALKKVLR
 1593- 1608 (26.44/12.92)	YlGGLWL.FAQFPGILR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.75|      75|     329|      79|     165|      14
---------------------------------------------------------------------------
   79-  163 (106.51/98.62)	LSGTL....SNHDMSFTQA.ADFLfylhETLQQARAPVYDIPSA.TEILLARTYN..........R....LPKCIEDLGMQPVLigEEREGAVkKLNSVlrtRLL
  405-  499 (94.24/59.46)	LKGGVhlwqSDNDVVLRRSiPDEL....ESSSEASGEEENVEEAgEEVLCVRAFGvshmalgisiRngrfLLRCPSTVLAAPMV..KEMEDAL.NLGSV...QAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17863 with Med14 domain of Kingdom Viridiplantae
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