Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MVANVDAAGGFELQALAENPPASPPWHQKFQDPDDGRQRFLLELEFVQLLANPTYIHHLAQNRYFDDEAFVGYLKYLLYWKQPEYAKYIMYPHAFFFLDMLQSANFRAAMAHPANKEIAHRQQFYFWKHYRNNRLKQILPRPLPEAPAPPPPPPPAPTPVVVAATAKPEGSTRAGAGERRKRKYANS |
Length | 187 |
Position | Middle |
Organism | Physcomitrella patens subsp. patens (Moss) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Bryophyta> Bryophytina> Bryopsida> Funariidae> Funariales> Funariaceae> Physcomitrium. |
Aromaticity | 0.14 |
Grand average of hydropathy | -0.595 |
Instability index | 60.14 |
Isoelectric point | 9.37 |
Molecular weight | 21502.27 |
Publications | PubMed=18079367 PubMed=29237241 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP17836 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 151.05| 44| 59| 40| 84| 1 --------------------------------------------------------------------------- 40- 84 (76.77/44.17) FLLEL....EFVQLLANPTY..IHHlAQNRYFDDEAFVGYLKYLLYWKQPE 96- 145 (74.28/39.10) FFLDMlqsaNFRAAMAHPANkeIAH.RQQFYFWKHYRNNRLKQILPRPLPE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PLPEAP 2) TPVVVAATAKPEGSTRAGAGERRKRKYANS 3) WKHYRNNRLKQI | 142 158 127 | 147 187 138 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab