<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17830

Description Uncharacterized protein
SequenceMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPADSASSTLMPMPTRRPVPSQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAPRYFSANRPETVVRNPVDPFSKGLNSGYADFFPWNGAHYEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDKDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKALIMRTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDNIAPNDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHSLSEKKRAERANLLRRAGNYSVAEEEQDIANAIRVVKHVVGLPLLPNDPLSGRKPMPLKRLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHPLSLTMFTAVRDIMETAEDYAMLADILGACAKTADSDVLASVADTVHSNLQIFCALGSADELFNSLIERLRMMNEEQRLVPRPLLAALDSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVLATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQSLAPEGSRGPATYLQELLQLVIMPLPQATGLIAEETYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVNGTEFPLDNIECQESLLETLRTLVLVDSSAVSNALGIKALPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPSAIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARAILLTPGGMPNQGTSSDPRLYYLFSSSPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1519
PositionKinase
OrganismGibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.192
Instability index53.20
Isoelectric point8.74
Molecular weight167287.79
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17830
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.32|      48|      93|    1287|    1343|       1
---------------------------------------------------------------------------
 1287- 1343 (71.11/62.72)	PPKmaqlSLG.MVEKLTDL.WEIVAAGPQE.RPNCHAAVLqhWLPAMLrfVNlHSLSSEP
 1383- 1433 (74.21/40.85)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARAIL..LTPGGM..PN.QGTSSDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     274.44|      91|      97|     766|     862|       2
---------------------------------------------------------------------------
  766-  862 (136.18/117.33)	DELTGQfiMKGHP.....LSLTMFTAVRDimETAEDYAMLADILGACAKTADSDVLASVADTVHSNLQIfcALGSADELFNSLIERL.RMMNEEQ..RLVPRPLL
  866-  964 (138.26/97.56)	DSLAQR..MAGHEviasqLRQELVQNDRN..NAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTRL..DPPTMNKLFRMIIPALeRGWEKEDdtRRVLATLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     217.00|      52|      86|       8|      67|       3
---------------------------------------------------------------------------
    8-   59 (89.68/45.65)	PQRSVSSS..SLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATP
   80-  111 (40.45/26.45)	...NASSS..SLPTSESP..QSLTPSR..IPNSDPFQ...AMVG..........
  113-  166 (86.87/43.80)	PADSASSTlmPMPTRRPVPSQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.87|      57|      91|     442|     500|       4
---------------------------------------------------------------------------
  442-  500 (91.91/67.97)	SRKYGRRLVFALLShlHVISNDPDKDLL..VQLSSRLSALLGSLIRSNPESFINPG............AWSTY
  536-  606 (87.96/58.30)	SPPAGRSQLVKLLD..AALKESSDNHLAaaCWATSENKALIMRTVVEWATSFHRPGlakvyaaarlirQWSQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.07|      23|      34|     381|     404|       6
---------------------------------------------------------------------------
  381-  404 (35.20/22.88)	ENDWKNRVTYAIrLATNLYSEQLL
  418-  440 (41.88/23.17)	ENSLQSRIPMWL.LIAQIYWKDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.70|      25|      42|     283|     311|      10
---------------------------------------------------------------------------
  283-  311 (35.60/30.51)	KREVWLKDlANPAISLRRLSRtipHGIRG
  326-  350 (45.10/25.09)	ERAVWLAK.CVGANEIRGLKR...KGVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.47|      17|      34|    1087|    1103|      15
---------------------------------------------------------------------------
 1087- 1103 (29.96/20.12)	LLEYSTVRNHVNGTEFP
 1122- 1138 (26.51/16.90)	LVDSSAVSNALGIKALP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17830 with Med12 domain of Kingdom Fungi
Unable to open file!