<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17828

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASVAFRIYEPPPDQSHAFQSSALEIQSSLRDQGKLVSYDADRVGIWIFQIVSKDGTNNLVNSAPGSSLEASGYTLGMVEEGTLEPVALQKSRIPGNTTQNAPNNAASTSSPAESNSRNPLISPTQVAGGALPDGGSQSSAQATDMKTPRIVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLQADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSIPDTNDSQWKHSCLKALEYCGLNPSQFKSSPWVNLLISKPASQDAEGESKRSRATVPWPGSLCFRKKPLEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRRAERMYAVPKEVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSLDGAISSPNNPPPTLAVVDADITIPTATPVPDAENDAWGGHHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDSNDLDMDMPDLQPVPTAPAPQVMPPPVLSHPHPQPQPHKVIEPQPEVKPKPKTNDSVFAKPELKHARSSLNEELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDLRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESDLESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDFTDEQLAIELPKLSKTESPEMLLNRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELNIARNSLQLLHDVMPSNLGTPTAVRLKALLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLGRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSQHKAAIIAEIWATTLTMISIWKVHWRVIITKSGVMDQREVEWWQAASTLDDKHSFTMIIMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGTKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1519
PositionKinase
OrganismGibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.383
Instability index49.82
Isoelectric point5.19
Molecular weight165916.59
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17828
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     884.61|     256|     283|     372|     654|       1
---------------------------------------------------------------------------
  372-  654 (418.45/277.26)	PLEMSTTHRVGDTMLSGHEE....CHDPLGDARGWFAGASEREERIS..KRRAER..MYAVPK.EVNG.AN.PLAQNL......NGQSPLTMRRPSTAAAGvmyptpPDA.IQQH.IGITPSLD...GAIS...............SPNNPPptlAVVDADITIPTATpvpdaenDA.WGGHHEQKRERSDSNAMgDSDDVMNDLGEDVFG.....DHD..V.............TEDDFNFFDGPDSNDLDM..DMPDLQPVPTAPA.PQVM...PPPVLSHphpqpqpHKVIEPQP.EVKPKPKTNDSV.FAK..............................PELKHARSSLneELNHRI...KVERPdTAKRGSSPF...D
  660-  943 (265.14/139.06)	.......KRVRASLSSPTKD..dfAVQPPRRKSSVFEKV.EFDPKIPliNKKYEHggAFDFSKdQSNGdLR.PSAHNLsrdeylEGQGKL..KQTSKSLLG......NSL.IRSL.TGIDASTT...HA.................SPQ............................rLNG.HDWISEESDLES..DGDDISSLSGGPVSPvkssiKRT..V.............VDDD.ALSQATTSRETELldDFTDEQLAIELPKlSKTE...SPEMLLN.......RFFLDPEPlNVDVGLSNHDFVeIAQiiteqaatgrleigiehkaessvslatmrsHELNIARNSL..QLLHDVmpsNLGTP.TAVRLKALLeiqD
  994- 1208 (201.02/101.15)	PSSMSFWEGLGLSPSWGTKDisalCIFP.....GW.KGMSDHVESFL..G.RLKS..VYESLK.LGTL.NNlPLSGDW.....dDGVLPYEVDRISTS.........PDAtVTGHgSALVESMEvlrSSLSelkskdknlviyfvySPDNPA...SIIEACTAFYRCF.......DE.YSDLLAARRE.SPQNEL.....VLQLVSLDMIS.....STTslVvptpaemiklcieTYDRCTLF.......LDT..EFGG..P..T.PA.PAVMleqPPP..........................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     295.71|      95|     135|     125|     227|       2
---------------------------------------------------------------------------
  125-  227 (149.13/119.03)	SSPAESNSRNP...LISPTQVAGGalpDGGSQSSAQATDMK..TPRIVPKIIYEQFIVAVISsiAFAFCSRSmaiPLNYRT.....MLI.PPLQADANERERGSLQADPVVGTF
  261-  366 (146.58/96.10)	SSPSSSVLAAPygvFATKQNFANG...DGSDRSLAQTPNTQalSVRSIPDTNDSQWKHSCLK..ALEYCGLN...PSQFKSspwvnLLIsKPASQDAEGESKRSRATVPWPGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.97|      21|     284|     947|     976|       3
---------------------------------------------------------------------------
  100-  120 (39.06/15.87)	EPVALQKSRIPG...NTTQNAPNN
  949-  972 (34.91/28.02)	QPSRLQPRPIPGrdpNAEQLRANN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17828 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GIDASTTHASPQRLNGHDWISEESDLESDGDDISSLSGGPV
2) ISKRRAERMYAVPKEVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSLDGAISSPNNPPPTLAVVDADITIPTATPVPDAENDAWGGHHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDSNDLDMDMPDLQPVPTAPAPQVMPPPVLSHPHPQPQPHKVIEPQPEVKPKPKTNDSVFAKPELKHARSSLNEELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKS
3) VALQKSRIPGNTTQNAPNNAASTSSPAESNSRNPLISPTQVAGGALPDGGSQSSAQATD
756
413
102
796
683
160










Molecular Recognition Features






MoRF SequenceStartStop




1) HDVTEDDFNF
2) VFKRVRA
546
658
555
664