<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17826

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPTAAMNGNSTVPSSDVEDGSGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFSGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTRQEQIQWISDLDTQLSLRLNLEDFDKIPYHFRNYEIDSGRVKFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFEPAASSIPDGLKNYLEGQVNDILSKDGLLGCYQFLHELVLTHKLNELKRQASQLSRGSWTGTLRVEPLNRALAIQYWTSRTQLGSPKSWILIAVNSGRKPNGQPDPKSSSHLTAKWYRDNKEVKDTNITFDADNLSAETLLKTVIGRHVEFLLGSIHNRLQAFPRFQNRDAAMILNISHDDPATSFLSMQVGYKDSASLLVEPTTGVFAVKPHSKFTIQHEHLLNNGKNPADDGAACLENVRCGVMEDELIRRGSTTGWTTKKSSMTKDELRSLTNTREWTKTIWLQRTGWDPNWFVMVMLSPNGDAWWLVDVSRNANGQSNRLSSKLPLNKGYPHLEDEFWNNLTLFATGMIAQAVDQHELYRHNIKFLLQDTRNWSLPQQVRLPTLEISLSDIFPSMVFNMAEKDNANAADESNAGTETSRLGPVAPTASTSGISTRQPWAHDIVSIRFKGVEPVDKEASGAGGPISDVSFMCVSDAIIKVRKPAKFAMLKGHMVGRDVSWKARTGEFCLRMRSNIGRSILENLKARVKAVDRFVSFFESLDKARGFIKAESVSLKEVTFSYGPPASQAVENAEASRLWRVALDLSNNDIDIQVQETNPHLPVTDLMQKLVNGANGIGALMDWLPVSLPTMEAFKKIREAWSDIEARRQGRFTFVMNSTDEMSFEYLLAGTGAGNQQVQRSITFLGQIKQRRGEPWWHIERKIPSSGWPSNDEFSAALKPVWDGKGDNWRGLVTGAAGRPENGIIGLLLAIDEAIRPLAGSTFQNNSELVILE
Length1018
PositionTail
OrganismGibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.08
Grand average of hydropathy-0.349
Instability index34.35
Isoelectric point6.46
Molecular weight113992.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17826
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.84|      25|      51|     180|     204|       1
---------------------------------------------------------------------------
  180-  204 (45.68/32.11)	DLDTQLSLRLNLEDFDK.................IPYHFRNY
  216-  257 (33.16/21.20)	AGEFEVDLTIADEDFEKqfwfidfrfafepaassIPDGLKNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     444.62|     138|     144|     648|     791|       2
---------------------------------------------------------------------------
  652-  723 (92.23/64.41)	......................................................................ANAADESNAGTE.TSRLGPVAPTASTSGISTRQ..PW..AHDIVSIRFKGVEPVDKEASGAGGPISDVSFMCVSDA..I
  724-  862 (202.14/145.46)	IKVRKPAKFAMLKGHMVGRDVSWKaRTGEFCLRMRSNIGRS...ILENLKARVKAVDRFVSFFESLDKARGFIKAESVSLKEvTFSYGPPASQAVENAEASRL...WrvALDLSN...NDID.IQVQETNPHLPVTDLMQKLVNGAngI
  869-  968 (150.26/104.62)	LPVSLPTMEAFKKIREAWSDIEAR.RQGRFTFVMNSTDEMSfeyLLAGTGAGNQQVQRSITFLGQIKQRR.................................gePW..WHIERKIPSSG.WPSNDEFSAALKPVWD............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.96|      47|      49|     423|     471|       3
---------------------------------------------------------------------------
  423-  471 (71.21/59.99)	DDPATSFLSMQVGYKDSASLLVEPTTGvFAVKpHSKFTIQHEHLLNNGK
  475-  521 (80.75/57.25)	DDGAACLENVRCGVMEDELIRRGSTTG.WTTK.KSSMTKDELRSLTNTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     249.92|     108|     216|     302|     421|       4
---------------------------------------------------------------------------
  302-  362 (63.09/46.65)	.................................................................................................................................................................WTGTLRvepLNRALAIQYWTSRTQLgSPK..SWILIAVnsGRKPNGQPDPKSSSHLTAKWYRD
  363-  421 (44.63/37.56)	NKEVKDtNITFDADNLSAETLLKTVIGRH.VEFLLGSIHNRlqAFPRfQNRDAAmiLNIS....................................................................................................................................................................
  523-  579 (77.83/39.76)	............................................................hddpatsflsmqvgykdsasllvepttgvfavkphskftiqhehllnngknpaddgaaclenvrcgvmedelirrgsttgwttkkssmtkdelrsltntreWTKTIW...LQRTGWDPNWFVMVML.SPNgdAWWLVDV..SRNANGQSNRLSSKLPLNKGYPH
  581-  634 (64.37/31.32)	EDEFWN.NLTLFATGMIAQAVDQHELYRHnIKFLLQDTRNW..SLPQ.QVRLPT..LEIS....................................................................................................................................................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17826 with Med14 domain of Kingdom Fungi
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