Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MATLNLDDDELKALEQTLSKVAQLSSSVQSFRQDLLKSNPLPPPKSIQASAKILQKNLKSLLESTNENADLFNRMAIRPSTNYPGRTQENVLLQLLRKKLEPDVEEFVSQGLETARLATPEGLESLEQIWRELRSWLSDRVIHFISTENSDPYTAEERANGVKNVRTGLRRPIDDDEEEEEDEEEGDEEEDDDEPEKPDIPEVKVRGAEPEALLWFAARGDFEVPRNVEYERKVDVYKGLQGINIPPSDQQQQQPQQGFAPS |
Length | 262 |
Position | Head |
Organism | Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.893 |
Instability index | 56.66 |
Isoelectric point | 4.46 |
Molecular weight | 29795.54 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP17825 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 187.43| 67| 72| 88| 158| 1 --------------------------------------------------------------------------- 14- 65 (55.33/29.58) .....................LEQT...LSKvaQLSSSVQSFRQDLLKSNPLPPPKSIQASAKILqKNLKSLLEST 71- 140 (107.38/69.06) LFNRMAIRPSTNYPGRtqeNVLLQL...LRK..KLEPDVEEFVSQGLETARLATPEGLESLEQIW.RELRSWLSDR 141- 179 (24.72/12.72) VIHFISTENSDPYTAEeraNGVKNVrtgLRR..PIDDDEEE................................... --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) RNVEYERKVDVYKGLQGINIPPS 2) VKVRGAEPEALLWFAAR | 226 203 | 248 219 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab