Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MVHGDDQPLSIRPSPVADRKPQNIAEFIARANAQPGGFRAINEAKLREELAREEAEYGDALDRDVDMADGDQDDDDDQDAPRDLQEVRIEMLKNLDAAGNTALLTLDFLSLLISKQNPTQAGVTLSQDLRDMVGIGTLGTDRLDNPPVTPAKVQEQENIALGLALTQTNKARDAAEAASAFLEKEVTVEGKYWEEITAVQKSGWSISRVPQERHTLGVRFGFSEAAPEYRNSLAPMRRGNDGAVQLDCGRLGGVSERVVVTYERDGQVTGRSALPAETAADAPLEERVLEARNTIFSQELWHELTREARTLAAYDVKPYDSRLICDIDPASKSRVILELVPLGPLASSDDDLPDNQIAETISLALHTLLSYAHRQNELTRTRPIPPHIPRSRGQQTHALLRPIIARLMHLHNVQVVTKHIGVLVQSLQRAGFPSRFVLSTTPISLNDSDPANQGPNQLASSQIMIRNMLQPIEFNIKLTILPNVSFTVRGRTFLMPVTATYYYVITPQNSPLSAACAPYREGYPDANALADYLGTATTRLLVEHYLAILPSPWSKGIQGNAILNAKNEDCRMVFTVTEEPALHLKSTSIVDGQLVSQEWTWSDDATKTHVQDIINTEVSKLNL |
Length | 623 |
Position | Head |
Organism | Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.347 |
Instability index | 45.18 |
Isoelectric point | 5.08 |
Molecular weight | 68741.64 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP17815 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 108.13| 35| 98| 323| 358| 3 --------------------------------------------------------------------------- 323- 358 (55.52/32.58) LICDIDPAS.KSRVILELVPLGpLASSDD.DLPDNQIA 423- 459 (52.61/26.38) LVQSLQRAGfPSRFVLSTTPIS.LNDSDPaNQGPNQLA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DLQEV 2) VADRKPQNIAEFIARA | 83 16 | 87 31 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab