<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17801

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRYPTCYVLVTDMDDPASSPSSAVHQGAASPAGTAMAMKSVGLPSSAAVASPPCSPCPQPITMRSRPPCPSSPFPVPASGHHPASMQHSPSPATRLPEHVWQDSTLNPTEQNSVGSDAIPSQQPQAGQWDFADPTRKAMCSCSKLMGGSGTPSGGPPSYPCGQAMTPNPLPNLHGGGSLGESVPVPSVGSPASAAPSPLPNPHSQPASVPPADQTMPTLSPHPPTSNSGAGQPQPATPLESQDKVTPAATPSDLNGPKSVSSVSNQVFSPYPATSSVEPVTKPVDSVGGGSQGPASAHSVVASAPLPTATPLDSLTLKRPVLSSKEYESILMEEDQPSELLYDYSTLDAWLNHPVKKFKPAEARPPDPMRPSPYNRRSSTNDLYSYHLQQQNVASSPNNLSQPFIKQEVKQEAGCNMSMEVDNIHLNKRSDPYEFEDDMTAPAVSMEGFKRTNSVKEEDRKGGPGNAIGPFDPVAPNGPTNKPTSLFTNEGLQASYKDLDQIFDNSDDTSSDETLQVPTPPGSNKPAGLPEDSASNNSAVVKPPRGSGGNTSLNSCGGAGILRPEELSKMFPTPPSLEHNPIASPCGHLSDGPLGELSDGPVGFCMGRYKQEIYPNMGSPQEENIEDWSYVFRLPAVCKFVGSSKYAPLTNLPSQSLPPVTLPSHCVYKPSWQTQYQQQQQFVEKSAPQQSIPNGSLVPSGPGTNSRPNSVASNHHSSTVMPPHTHLPHHAIHHTPVPPHSHSRAGLSPISPAGHFPPSPMTMAAMGGGGLPIHLQQQFRSGGPGSVGGVRTPCPAPPPYELPSPETSTASSYLNKNLNSVEPVPTPIMARAPEANSLVVNILLGDTALNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLQTPPPQPQPILPFPPTSPFPGMGMNGPPQYMVPSPGHHGIAPSVTEEDPIRCSCGFSAVVNRRLSHRSGLFYEDELEITGIAEDPGDRRKGSLLAYLLPNTGKSGQENINTGDVVDLVPQNVMELLKEQCVIIQSSSNSLYRASRQFRGSLGPDVPYGTTVNVLEFMDGNDVTCIALEQGRQALLESTTVAMCKVEEMQHRQQQIMQHGSRSSNTPCVHRWPYLRAMGPQCSQDIVWVMKSLRPLLQEVIHKKCTTRLWDAPYTVKGPLTWRQFHRLAGRGTEDRCEPQPIPSLMVGCEKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPDNDYILQRVRTFFRELSATYEVCRLGRHCPITKVLRDGILRVGKTAALKLAKEPVDEWFTMLGDNPATNMLKLYAQVCRHHLAPLLSQVPLDRTLLDPPEGSQPPRMIVDRPLPSPMPPPSTPESNQGQIPDKAPSTPKSDHDGDSNSNSRDPLMSGGQLSSAGDSNHDDDDVEPPALVVYLVDPFTIGSDSTDLQRLSCLSLLRCFTTVLSAIPESIRNNISVQLISLESIVELGKSRNRIRQNDHMRAQAFSVFSQCRRMLTHTSNIKALTGFGTAAMADLFLKNKDEKNRAPYRVYTPPYVLAPVKEKAESGESFGQCSGEQCSVLYVSYCLSEDQRWLLAVATDERGEIFETATINIDIPNRIRRKKASARRIGLQKLMDFILGVMSQSVRPWRLVVGRIGRIGHGELKGWSWLLSRKSLLKASKHLKEICEQCSLMYPSDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQTSVNCQLSTPHDVSCTHILVFPTSATSQSSQTAFQEQHINGPDLGDDELFSALNDDMPEGIEGMQDFNDIFSWPETGPGGAQSPTGSPRRGDSPSQPGSPSCGVGGTSDQHSPFPCNGSSRGGGSVGVDTQEEVGTLHQQPLALGFFVSTAPTGRMPKWFWASCPHLENVCPAFLKNALHLHSPAIQQNSDDLLQQQSAVTVHALDSQYTTDVLRYVLEGYNALSWLALDSNTRDRLSCLPVHVQALMQLYHVTSALV
Length1954
PositionMiddle
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.06
Grand average of hydropathy-0.435
Instability index61.24
Isoelectric point5.87
Molecular weight211242.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     830.57|     106|     107|      29|     134|       1
---------------------------------------------------------------------------
   29-   95 (107.91/29.07)	.................................................................................................ASPA.G...TAMA.....M...KSVGLPSSA.AVA.SP..P..CSPCPQPI.TMRSRP........PCP........S.S......P...FP...........VPASGHH...PA.......SMQHSPSP.ATR
   96-  198 (128.24/35.95)	LPEH.......VWQDSTLNPTE..QN...............SVGSD......AIPSQQ.PQ.........AGQWD........FA.............DPT.R...KAMCscsklM...GGSGTPSG......GP..P..SYPCGQAM.T....P.......nPLPnlhgggslG.E......S...VP...........VPSVGS....PA.......SA..APSP....
  199-  311 (95.03/24.71)	LPNP.......HSQPASVPPAD..QT..............mPTLSP......HPPTSN.SG.........AGQPQ........PATP....lesqdkVTPA.A...TPSD.....LngpKSVS.SVSN.QVF.SP.yP..ATSSVEPV.T...KPvdsvgggsQGP........A.S......A...HS...........VVAS...................APLPtATP
  312-  376 (70.03/16.26)	LDSL.......TLKRPVLSSKE..YE...............SI.........LMEEDQ.PS.........ELLYD........Y................................................................sTLDAWL........NHP........V.K......K...FK............PAEARP...PD.......PMR..PSP.YNR
  405-  524 (96.11/25.08)	IKQE.......VKQEAGCNM.....................SMEVD......NIHLNK..R.........SDPYE........FEDDmtapavsmegFKRT.N...SVKE.....E...DRKGGPGNAiGPF.DPvaP..NGPTNKPT.SLFTNE........GLQ........A.SykdldqI...FD...........NSDDTSS...DE.......TLQVPTPP.GSN
  525-  608 (73.37/17.39)	KPAG.......LPEDSASNNSAvvKP...............PRG.........................................................sG...GNTS.....L...NSCG...GA.GIL.RP..EelSKMFPTPP.SLEHNP.....iasPCG........HlS......D...GP...........LGELSDG...PV.......GFCMG......R
  609-  726 (68.99/15.90)	YKQE.......IYPNMG.SPQE..ENiedwsyvfrlpavckFVGSSkyapltNLPSQSlPPvtlpshcvyKPSWQtqyqqqqqFVE..............................................kSA..P..QQSIPNGS.LVPSGP........GTN........S.R......P...NS...........V.ASNHH...SS.......TVM..P.P.HTH
  727-  831 (108.67/29.33)	LPHH.......AIHHTPVPPHS..HS...............RAGLS......PI...S.P..........AGHF...........PP................spmTMAA.....M...GGGGLP..I.HLQ.QQ..F..RSGGPGSV.G.GVRT........PCP........A.P......PpyeLP...........SPETSTA...SSylnknlnSVEPVPTPiMAR
  832-  933 (82.24/20.39)	APEAnslvvniLLGDTALNIFR..DH...............NF..D......SCTLCV.CN.........AG..............P.....kvvgnIRGA.D...AGIY.....L...Q.............TP..P....PQPQPI.L....P........FPP........T.S......P...FPgmgmngppqymVPSPGHHgiaPS.......VTEEDP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      10|     109|    1539|    1550|       2
---------------------------------------------------------------------------
 1539- 1550 (16.75/14.44)	CsgEQCSVLYVS
 1653- 1662 (23.37/12.66)	C..EQCSLMYPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.10|      30|     115|    1006|    1035|       6
---------------------------------------------------------------------------
 1006- 1035 (50.69/34.02)	VMELLKE..QCVIIQSSSNSLYRASRQFRGSL
 1122- 1153 (50.41/33.79)	VMKSLRPllQEVIHKKCTTRLWDAPYTVKGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.54|      54|     516|    1360|    1419|       8
---------------------------------------------------------------------------
 1360- 1419 (89.75/58.85)	HDGDSNSNSRDPLMSGGQLS.SAGDSNHDDDdveppaLVVYLVDPFTIGS....DSTDLQRLSCL
 1878- 1936 (83.80/43.96)	HSPAIQQNSDDLLQQQSAVTvHALDSQYTTD......VLRYVLEGYNALSwlalDSNTRDRLSCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17801 with Med13 domain of Kingdom Metazoa
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