<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17800

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRYPTCYVLVTDMDDPASSPSSAVHQGAASPAGTAMAMKSVGLPSSAAVASPPCSPCPQPITMRSRPPCPSSPFPVPASGHHPASMQHSPSPATRLPEHVWQDSTLNPTEQNSVGSDAIPSQQPQAGQWDFADPTRKAMCSCSKCKKSPGAKHMAQNKGGVNNIGGVKALKVEKSEKGSRGSGRGGMMPFHRRSPLAEEGAWAVEVAGPLSRLMGGSGTPSGGPPSYPCGQAMTPNPLPNLHGGGSLGESVPVPSVGSPASAAPSPLPNPHSQPASVPPADQTMPTLSPHPPTSNSGAGQPQPATPLESQDKVTPAATPSDLNGPKSVSSVSNQVFSPYPATSSVEPVTKPVDSVGGGSQGPASAHSVVASAPLPTATPLDSLTLKRPVLSSKEYESILMEEDQPSELLYDYSTLDAWLNHPVKKFKPAEARPPDPMRPSPYNRRSSTNDLYSYHLQQQNVASSPNNLSQPFIKQEVKQEAGCNMSMEVDNIHLNKRSDPYEFEDDMTAPAVSMEGFKRTNSVKEEDRKGGPGNAIGPFDPVAPNGPTNKPTSLFTNEGLQASYKDLDQIFDNSDDTSSDETLQVPTPPGSNKPAGLPEDSASNNSAVVKPPRGSGGNTSLNSCGGAGILRPEELSKMFPTPPSLEHNPIASPCGHLSDGPLGELSDGPVGFCMGRYKQEIYPNMGSPQEENIEDWSYVFRLPAVCKFVGSSKYAPLTNLPSQSLPPVTLPSHCVYKPSWQTQYQQQQQFVEKSAPQQSIPNGSLVPSGPGTNSRPNSVASNHHSSTVMPPHTHLPHHAIHHTPVPPHSHSRAGLSPISPAGHFPPSPMTMAAMGGGGLPIHLQQQFRSGGPGSVGGVRTPCPAPPPYELPSPETSTASSYLNKNLNSVEPVPTPIMARAPEANSLVVNILLGDTALNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLQTPPPQPQPILPFPPTSPFPGMGMNGPPQYMVPSPGHHGIAPSVTEEDPIRCSCGFSAVVNRRLSHRSGLFYEDELEITGIAEDPGDRRKGSLLAYLLPNTGKSGQENINTGDVVDLVPQNVMELLKEQCVIIQSSSNSLYRASRQFRGSLGPDVPYGTTVNVLEFMDGNDVTCIALEQGRQALLESTTVAMCKVEEMQHRQQQIMQHGSRSSNTPCVHRWPYLRAMGPQCSQDIVWVMKSLRPLLQEVIHKKCTTRLWDAPYTVKGPLTWRQFHRLAGRGTEDRCEPQPIPSLMVGCEKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPDNDYILQRVRTFFRELSATYEVCRLGRHCPITKVLRDGILRVGKTAALKLAKEPVDEWFTMLGDNPATNMLKLYAQVCRHHLAPLLSQVPLDRTLLDPPEGSQPPRMIVDRPLPSPMPPPSTPESNQGQIPDKAPSTPKSDHDGDSNSNSRDPLMSGGQLSSAGDSNHDDDDVEPPALVVYLVDPFTIGSDSTDLQRLSCLSLLRCFTTVLSAIPESIRNNISVQLISLESIVELGKSRNRIRQNDHMRAQAFSVFSQCRRMLTHTSNIKALTGFGTAAMADLFLKNKDEKNRAPYRVYTPPYVLAPVKEKAESGESFGQCSGEQCSVLYVSYCLSEDQRWLLAVATDERGEIFETATINIDIPNRIRRKKASARRIGLQKLMDFILGVMSQSVRPWRLVVGRIGRIGHGELKGWSWLLSRKSLLKASKHLKEICEQCSLMYPSDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQTSVNCQLSTPHDVSCTHILVFPTSATSQSSQTAFQEQHINGPDLGDDELFSALNDDMPEGIEGMQDFNDIFSWPETGPGGAQSPTGSPRRGDSPSQPGSPSCGVGGTSDQHSPFPCNGSSRGGGSVGVDTQEEVGTLHQQPLALGFFVSTAPTGRMPKWFWASCPHLENVCPAFLKNALHLHSPAIQQNSDDLLQQQSAVTVHALDSQYTTDVLRYVLEGYNALSWLALDSNTRDRLSCLPVHVQALMQLYHVTSALV
Length2022
PositionMiddle
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.06
Grand average of hydropathy-0.444
Instability index61.39
Isoelectric point6.09
Molecular weight218310.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17800
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     892.61|     111|     111|     227|     337|       1
---------------------------------------------------------------------------
   17-  109 (83.04/21.31)	...................................ASSP....SS..........................A.V.........HQGAAS.PAGTAMA.M....KSVGlPSSAA.VAS....................P.....PC.......SP.C............PQ.PiTMRSR......PPCP..S..SpF..PVPASGhHPASMqhSPSPatrL.PEHVWQDS......TL...NPT
  110-  193 (72.79/17.80)	EQN..SVGS....D.........AIPSQ...QPQ.AGQW....DF..........................A.DPTRkamcscSKCKKS.PGAKH......................................................mAQNK.G............GV.N.NI..G......GVKA..L..K.V..EKSEKG.SRGSG..RGGM...M.P.FHRR................
  194-  280 (127.91/36.67)	........................SPLA...EEG.AWAV....EV..........................A.GPLS......RL..MG.GSGTPS...G.GP.............P...................sY.....PC..GQ.AMTP.N............PL.P.NLHGG......GSLG..E..S.V..PVPSVG.SPASA..APSP...L.PNPHSQPA......SV...PPA
  281-  373 (135.45/39.26)	DQT.MPTLS....P.........HPPTS...NSG.AGQP....QP..........................A.TPLE......SQDKVT.PAATPSD.LN.GPKSVS.SVSNQ.VFS...................pY.....PA..TS.SVEP.........................................VtkPVDSVG.G.GSQ..GPA.......SAHSVVA......SA...P..
  374-  447 (53.26/11.10)	....LPT................................................................A.TPLD......SLTLKR.P.......................VLS.................skeY.....ESilME.EDQP.S............EL....LYDY......STLD..AwlN.H..PVKKF..KPAEA.rPPDP...MrPSPYNRRS......S.......
  448-  579 (79.73/20.17)	..T.NDLYS....Y.........HLQQQ...NV..ASSPnnlsQPfikqevkqeagcnmsmevdnihlnkrS.DPYE......FEDDMTaPAVS....ME.GFKRTN.SVKEE.........................drkggP...GN.AIGPfD............PVaP.N...G......PTNK..P..T.S..LFTNEG.LQASY..KDLD...Q.IFDNSDDT......S......S
  580-  715 (107.61/29.72)	DET.LQV......P.........TPPGS...NKP.AGLP....ED..........................S.ASNN......SA.VVK.P...PRG.SG.GNTSLN.SCGGAgILRpeelskmfptppslehnpiaS.....PC..GH..LSD.G............PL.G.ELSDGpvgfcmGRYK..Q..E.I...YPNMG.SPQEE..NIED...W.SYVFRLPAvckfvgSS...KYA
  716-  827 (102.61/28.01)	PLTnLPSQS..............LPPVT.lpSHC.VYKP....SW..........................Q.TQYQ......QQQQFV.EKSAPQ..........Q.SIPNG.SLV..................psG.....P...GT.NSRP.NsvasnhhsstvmP..P.HTHLP......HHAI..H..H.T..PVPP.H.SHSRA..GLSP...IsPAGH...........F...PPS
  828-  956 (89.51/23.52)	PMT.MAAMGggglPihlqqqfrsGGPGS...VGG.VRTP....CP..........................ApPPYE......LPSPET.STAS.SY.LNkNLNSVE.PVPTP.IMA...................rA.....PE..AN.SLVV.N............IL.L....GD......TALNifR..D.H..NFDSCTlCVCNA..GPKV...V.GNIRGADA......GIylqTPP
  957- 1017 (40.69/ 6.80)	PQP.QPIL.....P.........FPPTSpfpGMGmNGPP....QY..........................M.VPSP......GHHGIA.PSVTEEDpIR.CSCGFS.AVVNR.RLS..............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      10|     109|    1607|    1618|       2
---------------------------------------------------------------------------
 1607- 1618 (16.75/17.13)	CsgEQCSVLYVS
 1721- 1730 (23.37/15.05)	C..EQCSLMYPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.68|      34|     764|    1026|    1062|       4
---------------------------------------------------------------------------
 1026- 1062 (50.52/41.79)	DELEITGiaEDPGDRRKGSLLAYLLPNtGKSGQENIN
 1799- 1832 (63.16/40.70)	QEQHING..PDLGDDELFSALNDDMPE.GIEGMQDFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.10|      30|     115|    1074|    1103|       5
---------------------------------------------------------------------------
 1074- 1103 (50.69/34.30)	VMELLKE..QCVIIQSSSNSLYRASRQFRGSL
 1190- 1221 (50.41/34.06)	VMKSLRPllQEVIHKKCTTRLWDAPYTVKGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.54|      54|     516|    1428|    1487|       7
---------------------------------------------------------------------------
 1428- 1487 (89.75/52.90)	HDGDSNSNSRDPLMSGGQLS.SAGDSNHDDDdveppaLVVYLVDPFTIGS....DSTDLQRLSCL
 1946- 2004 (83.80/39.56)	HSPAIQQNSDDLLQQQSAVTvHALDSQYTTD......VLRYVLEGYNALSwlalDSNTRDRLSCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17800 with Med13 domain of Kingdom Metazoa
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