<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17798

Description Src substrate cortactin
SequenceMWKASAGIKLDVSNGNDDDWETDPDFVNDVTEQEQRWGSRTVEGSGRTAGAIDMKKLREETAEADAILKQKQLEEGPKAAFGYGGKFGVQTDRMDQSAVGHDYVAKVEKHESQRDYSTGFGGKFGVQSDRQDKSAEDWEYREKIEKHGSQRDYSSGFGGKYGVQVDRQDKSAVGWDHVEKLEKHESQKDYAVGFGGKFGVQADRQDKSAVGWDHHEQLHQHESQTDHNKGFGGKFGVQRDRVDKSAHDFNEQPEKVGTNYEKLKPDIGSTKPSNLRMKFENLAKQGEEEAKKKAEEERDRRKKQEDLEERVAREQEEKRLKKQQEKEQEQQRKLQEHKLYLEQTMSQSISEPQQVVQPKPQARSSIQEDSVSPHSPVVPQSTVVPHSPVVPQSPVSNVRSESHVVQTPPTEEEDEEIDEDVAGAFDSVEDTGYSAIALYDYQAGAEDEISFDPDDIITNVEMIDEGWWRGYCHGQYGLFPANYVQLQQ
Length488
PositionTail
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.08
Grand average of hydropathy-1.200
Instability index56.10
Isoelectric point4.97
Molecular weight55382.55
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
actin binding	GO:0003779	IEA:InterPro

GO - Biological Process
actin filament polymerization	GO:0030041	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17798
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     323.97|      34|      34|     144|     177|       1
---------------------------------------------------------------------------
   74-  103 (51.18/26.96)	.....EEGPKAAF..GYGGKFGVQTDRMDQSAVGH...DY
  107-  143 (67.47/37.79)	VE...KHESQRDYSTGFGGKFGVQSDRQDKSAEDWeyrEK
  144-  177 (74.75/42.63)	IE...KHGSQRDYSSGFGGKYGVQVDRQDKSAVGW...DH
  178-  214 (68.88/38.73)	VEkleKHESQKDYAVGFGGKFGVQADRQDKSAVGW...DH
  218-  252 (61.69/33.95)	LH...QHESQTDHNKGFGGKFGVQRDRVDKSAHDF..nEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.22|      15|      17|     295|     309|       2
---------------------------------------------------------------------------
  295-  309 (27.23/15.37)	EEERD.RRKKQED...LEE
  325-  343 (15.98/ 6.12)	EKEQEqQRKLQEHklyLEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.35|      15|      16|     360|     375|       3
---------------------------------------------------------------------------
  360-  375 (22.15/15.38)	PQArSSIQEDSVSPHS
  379-  393 (27.20/14.46)	PQS.TVVPHSPVVPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.84|      13|      16|       2|      17|       4
---------------------------------------------------------------------------
    2-   14 (21.74/16.38)	WKASAGIKLDVSN
   20-   32 (24.10/ 9.10)	WETDPDFVNDVTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.19|      11|      17|     253|     263|       5
---------------------------------------------------------------------------
  253-  263 (18.88/12.51)	PEKVGTNYEKL
  272-  282 (19.30/12.92)	PSNLRMKFENL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17798 with Med29 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DRQDKSAVGWDHHEQLHQHESQTDHNKGFGGKFGVQRDRVDKSAHDFNEQPEKVGTNYEKLKPDIGSTKPSNLRMKFENLAKQGEEEAKKKAEEERDRRKKQEDLEERVAREQEEKRLKKQQEKEQEQQRKLQEHKLYLEQTMSQSISEPQQVVQPKPQARSSIQEDSVSPHSPVVPQSTVVPHSPVVPQSPVSNVRSESHVVQTPPTEEEDEEIDEDVAGAFD
2) DVSNGNDDDWETDPDFVNDVTEQEQRWGSRTVEGSGRTAGAIDMKK
203
11
426
56










Molecular Recognition Features






MoRF SequenceStartStop




1) IDMKKLR
2) MWKASAGIKLDV
3) YEKLKP
52
1
260
58
12
265