<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17765

Description Cyclin-dependent kinase 8
SequenceMMDYEFKLKTASERAKVEDLFDYEGCKVGRGTYGHVYKARRKDGSDPRDYALKQIEGTGLSMSACREIALLRELKHSNVINLIRVFLSHNDRKVFLLFDYAEHDLWHIIKFHRAAKANKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIVVYFTDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIKKMPEHPTLLKDFKRANYSNCSLVKYMDRHKIKPDSKAFHLLQKLLLMDPTKRITSEQAMQDAYFQEEPLPTQDVFAGCQIPYPKREFLTDDDNEDKSENKARQNQPQNGNQGGQGDQGNHNHNHGPNAKRVRLAPPHPVSTSSGMSSQQQQQQQPEFHHVQQQQQQQHVTQPGMIYSSSSNTQPTPNFSQRF
Length469
PositionKinase
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.09
Grand average of hydropathy-0.678
Instability index44.85
Isoelectric point8.76
Molecular weight54159.04
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17765
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.54|      31|      35|     136|     166|       1
---------------------------------------------------------------------------
  103-  128 (25.64/13.74)	.........HDLWhiiKFH..RAAKANKKPVMVPKGM
  136-  166 (57.32/39.46)	ILD.GIHYLHSNW...VLH..RDLKPANILVMGEGPE
  172-  204 (40.57/25.86)	IADmGFARLF.NA...PLKplADLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.50|      37|      40|     308|     345|       2
---------------------------------------------------------------------------
  268-  308 (53.20/30.22)	PLEKDWEDIK.....KMpehpTLLKDFKRANYSNCSLVKYMDRHKI
  310-  346 (59.75/39.76)	PDSKAFHLLQ.....KL....LLMDPTKRITSEQAMQDAYFQEEPL
  347-  383 (41.56/21.36)	PTQDVFAGCQipypkRE....FLTDDDNEDKSENKAR....QNQP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.98|      28|      28|     407|     434|       3
---------------------------------------------------------------------------
  407-  434 (49.49/35.56)	RVRLAPPHPVSTSSGM..SSQQQQQQQPEF
  436-  465 (46.49/32.91)	HVQQQQQQQHVTQPGMiySSSSNTQPTPNF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17765 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLTDDDNEDKSENKARQNQPQNGNQGGQGDQGNHNHNHGPNAKRVRLAPPHPVSTSSGMSSQQQQQQQPEFHHVQQQQQQQHVTQPGMIYSSSSNTQPTPNFSQRF
357
469










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRVRLAPPHPVSTS
2) VTQPGMIY
405
446
419
453