<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17758

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDKAKEWQLELLMEKLRSKAGQFKSFVESAKALRMSLLDKRYPVDSVEKNQLQKCLDILQHSIKVTSLQGMVERLESVTRQLGLKFSPGGSPLDWFISSDMFYLEVMLESTGGVKDVRIHHEGKVEQQSCEELVSCLSNGDFADFTAQLEGLASIYQLNAEKKVKCKAFSALQSLEADLATLATFQAFIKEPFNLVHKSPVGILEKRRGGHAMKLTYLVPPYDLLDQQTNSSLPLSVQEVTSRNLGYSVMVCMEGSAAHKLQTAPLISVNRSPNGKSSPLYAPLSANNSATLPACFALRLNNPMPMCLPLVRRIQQITEMECGDLSTPHPLLSLVTQHASTGQLDCANNRGLFVTLPDQQHCYFMTESKNLEGILVSNISFTHPAHVPQILMLLRQQALFNVLVSSCIRPASKHADLESVVMLEVTALSWQHLSVSFEHPLEETMTTAELDLTDISSIKCKVYGASNGENGCTPEHASKVLQRCWSIPVTMRSLIRLWQSQNLRSNGLAAGGNLSLPPGSDPGRGHGGSNGSHSMPPDFDVSHIKTEPDGGSLPHSQSLSGSGSRQGFGPDMPDTGVSFQSPGNPMDSSVSNTFQFGALLSGQGSGGKGPVLLNMLSEQTSNSKKQRKRTNKDGMWRSPKRKQSEECEIVLETSSSDSTPLGTPTSRDAPMETSLDCEEEKTGSDFGEEEIMPVQEVEEIIVRKARKEKKTSPPTIILDLAESKSLVAPSVSITPITSSSSNFNSVLTGMGLERRPGIEIIPIVSTPATSLHTSITITPISSKVVAADDRNNRDRKGGKSRTEDKMRPDKKRNKRKREDSPSGCSGGSGIAMGPPDKLPPKQDPLSKPVSVSIKPTESPPLTSVRPSSPASALRKVTSSPTHLNISMTKSGSSKPSTSHQSPKHSPGYTSSPKHHGTSSPKQQSSGGSGKPSMSALKSAANSPSTAGKSGSDVAKVKSSSSKDKDRKVSSSFSGGSSGSGSSPKLKSSSVKLKQLDMTSGSGDGSTGSQGGAGTPPSVTIDGSKSLSAVPQARNRKGSLSAVIDKLKSAQHQGPEPGEVVKEGRGSGTNPSTKIPGDTSGSTVSSSSKNPGEYMVKPSSEGIKITINKTRTKDSKSGVVKTSSSSTGSGSPKTHTGLKPGVNSGPASKKPHQMLQQKSASGNSSSSGISSSSSKAGSSSASGNPSSKIPSSTKSSSSPVSGILSKSTSKSSGSPKMSSLADASRRDNKPRPPKTSSDRDKSVFSKGADARKSSPVGMRDELESERPLKLVTAHAKMEPSLPPQLMVEGMIKSLDTKFQIPKLSARSGNLNEGDSKKQSSDKTAIGGTESSSRMDSGARPLDLVGKADASNASAKFQSLSKTTDDLKGSKIPAVVSVTPQIAISSLTTQALKQPTTTFPSVSSKLQDISIDTGPQISTPTSVAIVTSLPSSSSEPSSRESVEISRMKPDLSRSAQISGNNAKEETTIQATGKLENPAKSYSANNNNDPSVLSALHPNKSLDSSQNKFTSSSSQKQAEDSKKLVNLSDISSKSTGLNKMTPTPTTSQEAAEILLDMSASTSLPNKPLPADPQPGKLATVPERAVAVSAPSRRNTPPPPLPPPQPSVQVHIVQSPAATPTTASPMVITSPHSASPCSIDDELMDEALVGMGK
Length1649
PositionMiddle
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.03
Grand average of hydropathy-0.544
Instability index57.32
Isoelectric point9.34
Molecular weight174226.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     333.66|      47|      47|     855|     901|       1
---------------------------------------------------------------------------
  581-  620 (32.22/ 6.77)	SPGNPMDSSVS.................NTFQFGALLSGQG..................................S..........GGKGPVLLNMlsEQT
  621-  669 (36.20/ 8.65)	SNSKKQRKRTN.................KD.....GMWRSP...............KRKQSeeceivletsSSDST..........PLGTP..TS...RDA
  736-  774 (30.93/ 6.15)	........ITS.................SSSNFNSVLTGMG...............LERRP..........GIEII..........PIVSTPATSL..HTS
  810-  867 (51.57/15.94)	KKRNK.RKRED.................SPSGCS...GGSGiamgppdklppkqdpLSKPV..........SVSIK..........PTESPPLTSV..RPS
  868-  910 (70.35/24.84)	SPASALRKVTS.................SPTHLNISMTKSG...............SSKPS..........TSHQS..........PKHSPGYT......S
 1038- 1098 (32.15/ 6.73)	SLSAVIDKLKSaqhqgpepgevvkegrgSGT..NPSTKIPG...............DTSGS..........TVSSS.......sknPGE....YMV..KPS
 1144- 1196 (34.08/ 7.65)	GPAS..KK.....................PHQMLQQKSASG...............NSSSS........giSSSSSkagsssasgnPSSKIPSSTK..SSS
 1498- 1540 (46.17/13.38)	SLDSSQNKFTS.................SSSQKQAEDSKKL...............VN..............LSDI..........SSKSTGLNKM..TPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.03|      26|      26|     937|     962|       2
---------------------------------------------------------------------------
  921-  943 (30.18/ 8.61)	KQQSSGGSG....................KPSMSAlKSAANSP
  944-  970 (33.49/10.55)	STAGKSGSD................VAKVKSSSSKdKDRKVSS
 1174- 1214 (26.36/ 6.38)	KAGSSSASGnpsskipsstksssspVSGILSKSTS.KSSG.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.33|      23|      27|    1379|    1403|       3
---------------------------------------------------------------------------
 1379- 1403 (36.11/21.31)	QIAISslTTQALKQPT.....TTFPSVSSK
 1406- 1433 (31.22/13.05)	DISID..TGPQISTPTsvaivTSLPSSSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.17|      27|      27|     110|     136|       4
---------------------------------------------------------------------------
  110-  136 (48.17/25.21)	STGGVKDVRIHHEG..KVEQQSCEELVSC
  138-  166 (42.00/21.23)	SNGDFADFTAQLEGlaSIYQLNAEKKVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.52|      25|      27|     300|     324|       5
---------------------------------------------------------------------------
  279-  304 (36.82/23.94)	PLYAPLSAN.NSATLPACfaLRLNNPM
  305-  329 (45.74/31.82)	PMCLPLVRRIQQITEMEC..GDLSTPH
  330-  348 (24.97/13.48)	PL.LSLVTQHASTGQLDC..AN.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.59|      27|      27|    1561|    1587|       6
---------------------------------------------------------------------------
 1561- 1587 (49.20/23.42)	PNKPLPADPQPGKLATVPERAVAVSAP
 1593- 1612 (39.65/17.29)	PPPPLPP.PQPSVQVHI......VQSP
 1613- 1634 (32.75/12.85)	AATPTTASPM...VITSPHSASPCS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.72|      15|      27|     973|     987|       7
---------------------------------------------------------------------------
  560-  574 (23.56/ 7.89)	SGSGSRQGFGPDMPD
  973-  987 (26.16/ 9.81)	SGGSSGSGSSPKLKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.58|      24|      27|     374|     400|       8
---------------------------------------------------------------------------
  386-  410 (37.52/27.31)	HVP.QILMLLRQQAL.FnVLVS.SCIRP
  414-  440 (30.06/20.14)	HADlESVVMLEVTALsW.QHLSvSFEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      14|      17|     507|     521|      11
---------------------------------------------------------------------------
  507-  521 (22.65/12.86)	GlAAGGNLSLPPGSD
  527-  540 (28.51/12.81)	G.GSNGSHSMPPDFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      83.59|      17|      17|    1282|    1298|      12
---------------------------------------------------------------------------
 1282- 1298 (26.26/12.36)	P.QLMVE.GMIKS..LDTKFQ
 1300- 1317 (20.81/ 8.18)	P.KLSARsGNLNE..GDSKKQ
 1320- 1338 (18.26/ 6.23)	D.KTAIG.GTESSsrMDSGAR
 1339- 1356 (18.26/ 6.23)	PlDLVGK.ADASN..ASAKFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.08|      10|      26|    1108|    1118|      13
---------------------------------------------------------------------------
 1108- 1118 (13.59/11.87)	KTRTkDSKSGV
 1132- 1141 (19.49/11.77)	KTHT.GLKPGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17758 with Med1 domain of Kingdom Metazoa
Unable to open file!