<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17758

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDKAKEWQLELLMEKLRSKAGQFKSFVESAKALRMSLLDKRYPVDSVEKNQLQKCLDILQHSIKVTSLQGMVERLESVTRQLGLKFSPGGSPLDWFISSDMFYLEVMLESTGGVKDVRIHHEGKVEQQSCEELVSCLSNGDFADFTAQLEGLASIYQLNAEKKVKCKAFSALQSLEADLATLATFQAFIKEPFNLVHKSPVGILEKRRGGHAMKLTYLVPPYDLLDQQTNSSLPLSVQEVTSRNLGYSVMVCMEGSAAHKLQTAPLISVNRSPNGKSSPLYAPLSANNSATLPACFALRLNNPMPMCLPLVRRIQQITEMECGDLSTPHPLLSLVTQHASTGQLDCANNRGLFVTLPDQQHCYFMTESKNLEGILVSNISFTHPAHVPQILMLLRQQALFNVLVSSCIRPASKHADLESVVMLEVTALSWQHLSVSFEHPLEETMTTAELDLTDISSIKCKVYGASNGENGCTPEHASKVLQRCWSIPVTMRSLIRLWQSQNLRSNGLAAGGNLSLPPGSDPGRGHGGSNGSHSMPPDFDVSHIKTEPDGGSLPHSQSLSGSGSRQGFGPDMPDTGVSFQSPGNPMDSSVSNTFQFGALLSGQGSGGKGPVLLNMLSEQTSNSKKQRKRTNKDGMWRSPKRKQSEECEIVLETSSSDSTPLGTPTSRDAPMETSLDCEEEKTGSDFGEEEIMPVQEVEEIIVRKARKEKKTSPPTIILDLAESKSLVAPSVSITPITSSSSNFNSVLTGMGLERRPGIEIIPIVSTPATSLHTSITITPISSKVVAADDRNNRDRKGGKSRTEDKMRPDKKRNKRKREDSPSGCSGGSGIAMGPPDKLPPKQDPLSKPVSVSIKPTESPPLTSVRPSSPASALRKVTSSPTHLNISMTKSGSSKPSTSHQSPKHSPGYTSSPKHHGTSSPKQQSSGGSGKPSMSALKSAANSPSTAGKSGSDVAKVKSSSSKDKDRKVSSSFSGGSSGSGSSPKLKSSSVKLKQLDMTSGSGDGSTGSQGGAGTPPSVTIDGSKSLSAVPQARNRKGSLSAVIDKLKSAQHQGPEPGEVVKEGRGSGTNPSTKIPGDTSGSTVSSSSKNPGEYMVKPSSEGIKITINKTRTKDSKSGVVKTSSSSTGSGSPKTHTGLKPGVNSGPASKKPHQMLQQKSASGNSSSSGISSSSSKAGSSSASGNPSSKIPSSTKSSSSPVSGILSKSTSKSSGSPKMSSLADASRRDNKPRPPKTSSDRDKSVFSKGADARKSSPVGMRDELESERPLKLVTAHAKMEPSLPPQLMVEGMIKSLDTKFQIPKLSARSGNLNEGDSKKQSSDKTAIGGTESSSRMDSGARPLDLVGKADASNASAKFQSLSKTTDDLKGSKIPAVVSVTPQIAISSLTTQALKQPTTTFPSVSSKLQDISIDTGPQISTPTSVAIVTSLPSSSSEPSSRESVEISRMKPDLSRSAQISGNNAKEETTIQATGKLENPAKSYSANNNNDPSVLSALHPNKSLDSSQNKFTSSSSQKQAEDSKKLVNLSDISSKSTGLNKMTPTPTTSQEAAEILLDMSASTSLPNKPLPADPQPGKLATVPERAVAVSAPSRRNTPPPPLPPPQPSVQVHIVQSPAATPTTASPMVITSPHSASPCSIDDELMDEALVGMGK
Length1649
PositionMiddle
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.03
Grand average of hydropathy-0.544
Instability index57.32
Isoelectric point9.34
Molecular weight174226.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     333.66|      47|      47|     855|     901|       1
---------------------------------------------------------------------------
  581-  620 (32.22/ 6.77)	SPGNPMDSSVS.................NTFQFGALLSGQG..................................S..........GGKGPVLLNMlsEQT
  621-  669 (36.20/ 8.65)	SNSKKQRKRTN.................KD.....GMWRSP...............KRKQSeeceivletsSSDST..........PLGTP..TS...RDA
  736-  774 (30.93/ 6.15)	........ITS.................SSSNFNSVLTGMG...............LERRP..........GIEII..........PIVSTPATSL..HTS
  810-  867 (51.57/15.94)	KKRNK.RKRED.................SPSGCS...GGSGiamgppdklppkqdpLSKPV..........SVSIK..........PTESPPLTSV..RPS
  868-  910 (70.35/24.84)	SPASALRKVTS.................SPTHLNISMTKSG...............SSKPS..........TSHQS..........PKHSPGYT......S
 1038- 1098 (32.15/ 6.73)	SLSAVIDKLKSaqhqgpepgevvkegrgSGT..NPSTKIPG...............DTSGS..........TVSSS.......sknPGE....YMV..KPS
 1144- 1196 (34.08/ 7.65)	GPAS..KK.....................PHQMLQQKSASG...............NSSSS........giSSSSSkagsssasgnPSSKIPSSTK..SSS
 1498- 1540 (46.17/13.38)	SLDSSQNKFTS.................SSSQKQAEDSKKL...............VN..............LSDI..........SSKSTGLNKM..TPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.03|      26|      26|     937|     962|       2
---------------------------------------------------------------------------
  921-  943 (30.18/ 8.61)	KQQSSGGSG....................KPSMSAlKSAANSP
  944-  970 (33.49/10.55)	STAGKSGSD................VAKVKSSSSKdKDRKVSS
 1174- 1214 (26.36/ 6.38)	KAGSSSASGnpsskipsstksssspVSGILSKSTS.KSSG.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.33|      23|      27|    1379|    1403|       3
---------------------------------------------------------------------------
 1379- 1403 (36.11/21.31)	QIAISslTTQALKQPT.....TTFPSVSSK
 1406- 1433 (31.22/13.05)	DISID..TGPQISTPTsvaivTSLPSSSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.17|      27|      27|     110|     136|       4
---------------------------------------------------------------------------
  110-  136 (48.17/25.21)	STGGVKDVRIHHEG..KVEQQSCEELVSC
  138-  166 (42.00/21.23)	SNGDFADFTAQLEGlaSIYQLNAEKKVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.52|      25|      27|     300|     324|       5
---------------------------------------------------------------------------
  279-  304 (36.82/23.94)	PLYAPLSAN.NSATLPACfaLRLNNPM
  305-  329 (45.74/31.82)	PMCLPLVRRIQQITEMEC..GDLSTPH
  330-  348 (24.97/13.48)	PL.LSLVTQHASTGQLDC..AN.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.59|      27|      27|    1561|    1587|       6
---------------------------------------------------------------------------
 1561- 1587 (49.20/23.42)	PNKPLPADPQPGKLATVPERAVAVSAP
 1593- 1612 (39.65/17.29)	PPPPLPP.PQPSVQVHI......VQSP
 1613- 1634 (32.75/12.85)	AATPTTASPM...VITSPHSASPCS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.72|      15|      27|     973|     987|       7
---------------------------------------------------------------------------
  560-  574 (23.56/ 7.89)	SGSGSRQGFGPDMPD
  973-  987 (26.16/ 9.81)	SGGSSGSGSSPKLKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.58|      24|      27|     374|     400|       8
---------------------------------------------------------------------------
  386-  410 (37.52/27.31)	HVP.QILMLLRQQAL.FnVLVS.SCIRP
  414-  440 (30.06/20.14)	HADlESVVMLEVTALsW.QHLSvSFEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      14|      17|     507|     521|      11
---------------------------------------------------------------------------
  507-  521 (22.65/12.86)	GlAAGGNLSLPPGSD
  527-  540 (28.51/12.81)	G.GSNGSHSMPPDFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      83.59|      17|      17|    1282|    1298|      12
---------------------------------------------------------------------------
 1282- 1298 (26.26/12.36)	P.QLMVE.GMIKS..LDTKFQ
 1300- 1317 (20.81/ 8.18)	P.KLSARsGNLNE..GDSKKQ
 1320- 1338 (18.26/ 6.23)	D.KTAIG.GTESSsrMDSGAR
 1339- 1356 (18.26/ 6.23)	PlDLVGK.ADASN..ASAKFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.08|      10|      26|    1108|    1118|      13
---------------------------------------------------------------------------
 1108- 1118 (13.59/11.87)	KTRTkDSKSGV
 1132- 1141 (19.49/11.77)	KTHT.GLKPGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17758 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KQPTTTFPSVSSKLQDISIDTGPQISTPTSVAIVTSLPSSSSEPSSRESVEISRMKPDLSRSAQISGNNAKEETTIQATGKLENPAKSYSANNNNDPSVLSALHPNKSLDSSQNKFTSSSSQKQAEDSKKLVNLSDISSKSTGLNKMTPTPTTSQEAAEILLDMSASTSLPNKPLPADPQPGKLATVPERAVAVSAPSRRNTPPPPLPPPQPSVQVHIVQSPAATPTTASPMVITSPHSASPCSIDDELMDEALVGMGK
2) LAAGGNLSLPPGSDPGRGHGGSNGSHSMPPDFDVSHIKTEPDGGSLPHSQSLSGSGSRQGFGPDMPDTGVSFQSPGNPMDSSVSNTFQFGALLSGQGSGGKGPVLLNMLSEQTSNSKKQRKRTNKDGMWRSPKRKQSEECEIVLETSSSDSTPLGTPTSRDAPMETSLDCEEEKTGSDFGEEEIMPVQEVEEIIVRKARKEK
3) LHTSITITPISSKVVAADDRNNRDRKGGKSRTEDKMRPDKKRNKRKREDSPSGCSGGSGIAMGPPDKLPPKQDPLSKPVSVSIKPTESPPLTSVRPSSPASALRKVTSSPTHLNISMTKSGSSKPSTSHQSPKHSPGYTSSPKHHGTSSPKQQSSGGSGKPSMSALKSAANSPSTAGKSGSDVAKVKSSSSKDKDRKVSSSFSGGSSGSGSSPKLKSSSVKLKQLDMTSGSGDGSTGSQGGAGTPPSVTIDGSKSLSAVPQARNRKGSLSAVIDKLKSAQHQGPEPGEVVKEGRGSGTNPSTKIPGDTSGSTVSSSSKNPGEYMVKPSSEGIKITINKTRTKDSKSGVVKTSSSSTGSGSPKTHTGLKPGVNSGPASKKPHQMLQQKSASGNSSSSGISSSSSKAGSSSASGNPSSKIPSSTKSSSSPVSGILSKSTSKSSGSPKMSSLADASRRDNKPRPPKTSSDRDKSVFSKGADARKSSPVGMRDELESERPLKLVTAHAKMEPSLPPQLMVEGMIKS
4) TKFQIPKLSARSGNLNEGDSKKQSSDKTAIGGTESSSRMDSGARPLDLVGKA
1391
508
771
1295
1649
709
1292
1346










Molecular Recognition Features






MoRF SequenceStartStop




1) ATVPERAVA
2) EILLDM
3) PKLKSSSVKLKQLDMT
4) SKKPHQML
5) SLSAVIDKLKSAQ
1575
1549
983
1147
1038
1583
1554
998
1154
1050