<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17757
Description |
Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | MDKAKEWQLELLMEKLRSKAGQFKSFVESAKALRMSLLDKRYPVDSVEKNQLQKCLDILQHSIKVTSLQGMVERLESVTRQLGLKFSPGGSPLDWFISSDMFYLEVMLESTGGVKDVRIHHEGKVEQQSCEELVSCLSNGDFADFTAQLEGLASIYQLNAEKKVKCKAFSALQSLEADLATLATFQAFIKEPFNLVHKSPVGILEKRRGGHAMKLTYLVPPYDLLDQQTNSSLPLSVQEVTSRNLGYSVMVCMEGSAAHKLQTAPLISVNRSPNGKSSPLYAPLSANNSATLPACFALRLNNPMPMCLPLVRRIQQITEMECGDLSTPHPLLSLVTQHASTGQLDCANNRGLFVVCFGSLCYFIETQLLVLWYTRRGRCNILNF |
Length | 384 |
Position | Middle |
Organism | Cryptotermes secundus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae>
Kalotermitidae> Cryptotermitinae> Cryptotermes.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.094 |
Instability index | 53.97 |
Isoelectric point | 8.19 |
Molecular weight | 42774.10 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP17757
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.17| 27| 27| 110| 136| 1
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110- 136 (48.17/31.68) STGGVKDVRIHHEG..KVEQQSCEELVSC
138- 166 (42.00/26.82) SNGDFADFTAQLEGlaSIYQLNAEKKVKC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.18| 26| 28| 279| 304| 2
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279- 304 (47.12/28.55) PLYAPLSAN.NSATLPACFALRLNNPM
305- 331 (43.06/25.52) PMCLPLVRRiQQITEMECGDLSTPHPL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.18| 11| 28| 2| 12| 3
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2- 12 (19.04/14.53) DKAKEWQLELL
28- 38 (17.14/12.31) ESAKALRMSLL
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