<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17754

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPFGNNVPQEGSRGGSISLAVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNFSARTRQLFVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRERIVPPDPITSSERRSTLLRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFTVEHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHSLQVQYIHQVIQSRLVDNPQPLTEVYHCLHFFCQSLQLEVLYSQTLRLCRDRLDDHIHVDEYTPGKCLSISYWRELTCKDPRSELGYRLTVQVDTHEPARPLTVIHVPSLGSKECEIADRAIRSDLLSMERLLVHTIYVRTRSRLTELKQELQTMLKDVECHLQGSPAILSVPVLQPCLRAEQLLITVDTHTGMLQCHVPQYDAPLIPELQTALNGDHSRLPTLVSELRYWITQRRCEKTLQHLPATPHERLPLLHHPDHPMSKIGRHRMFVRLHKHPNVILIVEFKEKESTQCEIDCSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVLTLIEFDTFVITHGPFTSVDDQSEKFPQKRKAGGRQEPGSRRTKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLRLVQLPPPPGVDTQSASWLALLKRLLSVAIRVQGKATKSWMAEFVFYGSPLASSHPKEQGLRRPVYFQFDMGTAETVSKTVDALLSDWAQIVHLYTVVEDLAEYFRIEKYNLSNMVTIKSYSYSRLVLGYGPERGATVTVDWNSSDKAFRLIFGATNSCVNAHSLLREQLEAHLNRHRNLAQIVHLLHETYEPLISISKLPTIPQLGVHNQRPQVPVQTFTIMPQSPTLLRVAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFMGQTGISHLSRVLPQRSWAGAVPTLLTHEALDLLCSPSPHPQHLPGPELSPLERFLGCVYMRRQLQRFIQNEDCLAGIPSTEPGVVNFKVESLQCRVGLNPQHLQSLHIKVSPLPDHKEQWSAEEMQIIEKFFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELMPGLVQQQQMKWAVQWSLRTPPSATPIVPIGMAAVLVCRTKILFFLQITRIGGPYPSSMEAPSLVLPLVYDVSTNLTQLAEKRDPGPASATTAASLQLKRFAEFGVSHNECSLFPAVRDLLCTLSLPSESQAQVASSPAPPTMQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
Length1480
PositionTail
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.06
Grand average of hydropathy-0.234
Instability index58.74
Isoelectric point7.52
Molecular weight164669.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     406.17|      76|      80|     969|    1048|       1
---------------------------------------------------------------------------
  893-  969 (72.93/25.24)	PQSPTLLRVAYQG.MYCLELRLRG..........G...G...LvslrdgaysRFDrsnvvDEFTPTQGLKA.F..LSKYVDETAVFRR..RSQSEDDNP...
  970- 1044 (137.03/59.11)	.PSPITMDSDGGGPMSFLGAHHRGPQSPAQ.QREG...G...L.........RFH.....PPLTPPSGSNP.H..TPASPHPTMSQAG..QHQSFGSSPATS
 1050- 1110 (86.81/29.82)	PPS.........LPPNI....NPSPSMLPH.PSPG...G...L.........LAN.....SP......SNPlHvpSPAGIMPT.SSPGpcPNVPVGHSPAGS
 1111- 1161 (47.86/13.61)	.............FMGQTGISHLSRVLPQR.SWAG...AvptL.........LTH.....EALDLLCSPSP.H..PQHLPGPELS.................
 1423- 1474 (61.54/19.95)	.............PPTM....QPSPAMQMHsPMPGgvvG...L.........PPQ.....PGAGPPQQPG..G..PPQPPYPVGIAMG..QH..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.33|      69|      78|     387|     464|       2
---------------------------------------------------------------------------
  333-  392 (37.10/14.72)	......................................RLTVQVDTHepaRPLTVIHV...PSLGSKECEIADRAIRSDLLsmerllvhtiyvrtrsRLTE
  393-  468 (111.34/69.93)	LKQELQTMLKDVEChLQGspailsVPVLQPC...LRAEQLLITVDTH...TGMLQCHV...PQYDAPLIPELQTALNGDHS................RLPT
 1172- 1213 (41.89/16.14)	MRRQLQRFIQNEDC.LAG......IPSTEPGvvnFKVESL..............QCRVglnPQ......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.08|      10|      78|     173|     182|       3
---------------------------------------------------------------------------
  147-  156 (17.98/ 9.26)	LPACIRERIV
  173-  182 (17.09/ 8.48)	LNQVIQHRLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17754 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESQAQVASSPAPPTMQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
2) VFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFM
1412
957
1480
1112










Molecular Recognition Features






MoRF SequenceStartStop




NANANA