<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17753

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPFGNNVPQEGSRGGSISLAVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNFSARTRQLFVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRERIVPPDPITSSERRSTLLRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFTVEHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHSLQVQYIHQVIQSRLVDNPQPLTEVYHCLHFFCQSLQLEVLYSQTLRLCRDRLDDHIHVDEYTPGKCLSISYWRELTCKDPRSELGYRLTVQVDTHEPARPLTVIHVPSLGSKECEIADRAIRSDLLSMERLLVHTIYVRTRSRLTELKQELQTMLKDVECHLQGSPAILSVPVLQPCLRAEQLLITVDTHTGMLQCHVPQYDAPLIPELQTALNGDHSRLPTLVSELRYWITQRRCEKTLQHLPATPHERLPLLHHPDHPMSKIGRHRMFVRLHKHPNVILIVEFKEKESTQCEIDCSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVLTLIEFDTFVITHGPFTSVDDQSEKFPQKRKAGGRQEPGSRRTKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLRLVQLPPPPGVDTQSASWLALLKRLLSVAIRVQGKATKSWMAEFVFYGSPLASSHPKEQGLRRPVYFQFDMGTAETVSKTVDALLSDWAQIVHLYTVVEDLAEYFRIEKYNLSNMVTIKSYSYSRLVLGYGPERGATVTVDWNSSDKAFRLIFGATNSCVNAHSLLREQLEAHLNRHRNLAQIVHLLHETYEPLISISKLPTIPQLGVHNQRPQVPVQTFTIMPQSPTLLRVAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFMGQTGHTDGSPFPSSQSMASPATSNWPGSPSMPRPSPARPGQSPGGTGHSALHSPQADHKPGISHLSRVLPQRSWAGAVPTLLTHEALDLLCSPSPHPQHLPGPELSPLERFLGCVYMRRQLQRFIQNEDCLAGIPSTEPGVVNFKVESLQCRVGLNPQHLQSLHIKVSPLPDHKEQWSAEEMQIIEKFFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELMPGLVQQQQMKWAVQWSLRTPPSATPIVPIGMAAVLVCRTKILFFLQITRIGGPYPSSMEAPSLVLPLVYDVSTNLTQLAEKRDPGPASATTAASLQLKRFAEFGVSHNECSLFPAVRDLLCTLSLPSESQAQVASSPAPPTMQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
Length1537
PositionTail
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.06
Grand average of hydropathy-0.266
Instability index60.94
Isoelectric point7.68
Molecular weight170364.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     481.74|      80|      80|     969|    1048|       1
---------------------------------------------------------------------------
  969- 1025 (96.82/36.73)	............................P.PSPI.TMDSDGGGPMSFL...GAHHRGPQS......PAQQREGG...LRFHPPL..TPPSGSNPHTPASPH
 1026- 1066 (75.25/26.75)	PTMSQAGQHQSFGSSPATSFNLA.........................................................SPPS..LPPN.INPSPSMLPH
 1067- 1123 (96.75/36.70)	P..SPGGL...LANSPSNPLH.......V.PSPAgIMPTSSPGPCPNV...PVGH....S......PA..................GSFMGQTGHTDGSPF
 1124- 1214 (96.93/36.78)	PS......SQSM.ASPATS.NWPgspsmPrPSPArPGQSPGGTGHSALhspQADHKPGIShlsrvlPQRSWAGAvptLLTHEAL..DLLCSPSPHPQHLPG
 1467- 1536 (115.99/45.60)	PSESQ...AQ.VASSPAPP.TMQ.......PSPAmQMHSPMPGGVVGL...P..PQPGAG......PPQQPGGP...P..QPPYpvGIAMGQ..HPMMGP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     250.96|      74|      78|     387|     464|       2
---------------------------------------------------------------------------
  333-  421 (92.50/63.72)	...RLTVQVDTHepaRPLTVIHVPSLGSKECEIAD....RAIRSDLLsmerllvhtiyvrtrSRLTELKQELQTMLKDVECH..LQGSPAI..LSVPVLQ
  425-  501 (116.83/87.67)	RAEQLLITVDTH...TGMLQCHVPQYDAPLIPELQ....TALNGDH................SRLPTLVSELRYWITQRRCEktLQHLPATphERLPLLH
  502-  544 (41.63/18.69)	HPDHPMSKIGRH...RMFVRLH.KHPNVILIVEFKekesTQCEIDCS.....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.09|      30|     533|      94|     127|       3
---------------------------------------------------------------------------
   94-  127 (38.70/41.11)	AHIMAFLDKQsLLFVDTADMLARmaREtLVHARL
  629-  658 (53.39/36.19)	AHVVALCDER.IPFVTLAQELTR..RE.IAHQGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.34|      20|      20|     855|     874|       4
---------------------------------------------------------------------------
  834-  854 (24.65/11.41)	LLREQLEAhLNRHRNLAQIVH
  855-  874 (32.83/17.85)	LLHETYEP.LISISKLPTIPQ
  875-  894 (31.87/17.10)	LGVHNQRP.QVPVQTFTIMPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.08|      10|      83|     173|     182|       5
---------------------------------------------------------------------------
  147-  156 (17.98/11.79)	LPACIRERIV
  173-  182 (17.09/10.81)	LNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.68|      44|      83|    1300|    1343|       6
---------------------------------------------------------------------------
 1217- 1252 (25.12/ 8.68)	...............LSPLERFLGCVYmrRQLQRFIQnedclagIPSTE..PG
 1300- 1343 (77.14/43.33)	FFDTRAAAPPYKPNALSGFGRMLNVPY..NVLKDFVQ.......IMKLELMPG
 1357- 1391 (49.15/24.69)	SLRTPPSATPIVP...IGMAAVLVCRT..KILF.FLQ.......ITRI.....
 1393- 1426 (46.26/22.76)	........GPY.PSSMEAPSLVLPLVY..DVSTNLTQ.......LAE.KRDPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.01|      18|      21|     670|     689|       7
---------------------------------------------------------------------------
  670-  689 (30.01/23.57)	RLVQLP.PPPGVDTQsaSWLA
  693-  711 (27.00/14.18)	RLLSVAiRVQGKATK..SWMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.81|      48|     629|     264|     313|       8
---------------------------------------------------------------------------
  264-  313 (85.76/68.90)	PQPLTEVYHCLhfFCQSLQLEVLYSQTLR.LCRDRLDDHIHVDEYTPGKCL
  896-  944 (81.04/57.22)	PTLLRVAYQGM..YCLELRLRGGGLVSLRdGAYSRFDRSNVVDEFTPTQGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.96|      10|      20|     216|     225|       9
---------------------------------------------------------------------------
  216-  225 (21.40/12.63)	GDGPNIPWRL
  238-  247 (17.56/ 8.87)	GDGKALVHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.41|      14|      24|     785|     798|      10
---------------------------------------------------------------------------
  785-  798 (24.23/14.99)	VTIKSYSYS...RLVLG
  807-  823 (21.18/12.21)	VTVDWNSSDkafRLIFG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17753 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESQAQVASSPAPPTMQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
2) VFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFMGQTGHTDGSPFPSSQSMASPATSNWPGSPSMPRPSPARPGQSPGGTGHSALHSPQADHKPGISHLSRVL
1469
957
1537
1181










Molecular Recognition Features






MoRF SequenceStartStop




NANANA