<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17752

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPFGNNVPQEGSRGGSISLAVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNFSARTRQLFVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRERIVPPDPITSSERRSTLLRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFTVEHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHSLQVQYIHQVIQSRLVDNPQPLTEVYHCLHFFCQSLQLEVLYSQTLRLCRDRLDDHIHVDEYTPGKCLSISYWRELTCKDPRSELGYRLTVQVDTHEPARPLTVIHVPSLGSKECEIADRAIRSDLLSMERLLVHTIYVRTRSRLTELKQELQTMLKDVECHLQGSPAILSVPVLQPCLRAEQLLITVDTHTGMLQCHVPQYDAPLIPELQTALNGDHSRLPTLVSELRYWITQRRCEKTLQHLPATPHERLPLLHHPDHPMSKIGRHRMFVRLHKHPNVILIVEFKEKESTQCEIDCSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVLTLIEFDTFVITHGPFTSVDDQSEKFPQKRKAGGRQEPGSRRTKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLRLVQLPPPPGVDTQSASWLALLKRLLSVAIRVQGKATKSWMAEFVFYGSPLASSHPKEQGLRRPVYFQFDMGTAETVSKTVDALLSDWAQIVHLYTVVEDLAEYFRIEKYNLSNMVTIKSYSYSRLVLGYGPERGATVTVDWNSSDKAFRLIFGATNSCVNAHSLLREQLEAHLNRHRNLAQIVHLLHETYEPLISISKLPTIPQLGVHNQRPQVPVQTFTIMPQSPTLLRVAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFMGQTGHTDGSPFPSSQSMASPATSNWPGSPSMPRPSPARPGQSPGGTGHSALHSPQADHKPGISHLSRVLPQRSWAGAVPTLLTHEALDLLCSPSPHPQHLPGPELSPLERFLGCVYMRRQLQRFIQNEDCLAGIPSTEPGVVNFKVESLQCRVGLNPQHLQSLHIKVSPLPDHKEQWSAEEMQIIEKFFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELMPGLVQQQQMKWAVQWSLRTPPSATPIVPIGMAAVLVCRTKILFFLQITRIGGPYPSSMEAPSLVLPLVYDVSTNLTQLAEKRDPGPASATTAASLQLKRFAEFGVSHNECSLFPAVRDLLCTLSLPSESQAQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
Length1526
PositionTail
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.06
Grand average of hydropathy-0.267
Instability index60.62
Isoelectric point7.68
Molecular weight169297.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17752
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     509.91|      80|      80|     969|    1048|       1
---------------------------------------------------------------------------
  894-  969 (63.98/22.49)	QSPT.LLRVAYQG.MYCL...ELRLRG...............GGLvslrdgaysRFDrsnvvDEFTPTQGLKAFLSKYVDETAVFRRRSQSEDD..NP.............
  970- 1048 (148.79/63.29)	PSPI.TMDSDGGGPMSFL...GAHHRGPQS......PAQQREGGL.........RFH.....PPLTPPSGSNPHTPASPHPTMSQAGQHQSFGS..SPATSFNLA......
 1049- 1083 (37.74/ 9.88)	........................................................S.....PPSLPPN.INPSPSMLPHP..SPGGL...LAN..SPSNPLH.......V
 1084- 1144 (86.49/33.32)	PSPAgIMPTSSPGPCPNV...PVGH....S......PA...........................GSFMGQTGHTDGSPFPS......SQSM.A..SPATS.NWPgspsmP
 1146- 1223 (88.68/34.38)	PSPArPGQSPGGTGHSALhspQADHKPGIShlsrvlPQRSWAGAV.................PTLLTHEALDLLCSPSPHP......QHLP.GPelSPLERF.........
 1474- 1524 (84.23/32.23)	PSPAmQMHSPMPGGV..V...GLPPQPGAG......PPQQ.PGG..................PP............QPPYPVGIAMGQHPMMG..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.96|      74|      77|     388|     464|       2
---------------------------------------------------------------------------
  333-  372 (31.65/12.54)	............................................RLTVQVDTHepaRPLTVIHVPSLGSKECEIAD....RAIRSDLL
  388-  463 (113.63/79.84)	SRLTELKQELQTMLKDVECH..LQGSPAI..LSVPVLQpclRAEQLLITVDTH...TGMLQCHVPQYDAPLIPELQ....TALNGDH.
  464-  544 (111.68/69.65)	SRLPTLVSELRYWITQRRCEktLQHLPATphERLPLLH...HPDHPMSKIGRH...RMFVRLH.KHPNVILIVEFKekesTQCEIDCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.01|      18|      21|     670|     689|       3
---------------------------------------------------------------------------
  670-  689 (30.01/24.82)	RLVQLP.PPPGVDTQsaSWLA
  693-  711 (27.00/15.10)	RLLSVAiRVQGKATK..SWMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.08|      10|      78|     173|     182|       4
---------------------------------------------------------------------------
  147-  156 (17.98/ 9.08)	LPACIRERIV
  173-  182 (17.09/ 8.31)	LNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.69|      20|      21|     834|     854|       5
---------------------------------------------------------------------------
  834-  854 (29.86/25.12)	LLREQLEAhLNRHRNLAQI....VH
  855-  878 (29.83/18.83)	LLHETYEP.LISISKLPTIpqlgVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.26|      44|      82|    1300|    1343|       6
---------------------------------------------------------------------------
 1300- 1343 (76.91/43.52)	FFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELMPG
 1357- 1391 (50.72/26.05)	SLRTPPSATPIVP...IGMAAVLVCRTKILF.FLQITRI.....
 1393- 1426 (48.63/24.66)	........GPY.PSSMEAPSLVLPLVYDVSTNLTQLAE.KRDPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17752 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SESQAQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
2) VFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFMGQTGHTDGSPFPSSQSMASPATSNWPGSPSMPRPSPARPGQSPGGTGHSALHSPQADHKPGISHLSRVL
1468
957
1526
1181










Molecular Recognition Features






MoRF SequenceStartStop




NANANA