<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17751

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPFGNNVPQEGSRGGSISLAVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNFSARTRQLFVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRERIVPPDPITSSERRSTLLRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFTVEHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHSLQVQYIHQVIQSRLVDNPQPLTEVYHCLHFFCQSLQLEVLYSQTLRLCRDRLDDHIHVDEYTPGKCLSISYWRELTCKDPRSELGYRLTVQVDTHEPARPLTVIHVPSLGSKECEIADRAIRSDLLSMERLLVHTIYVRTRSRLTELKQELQTMLKDVECHLQGSPAILSVPVLQPCLRAEQLLITVDTHTGMLQCHVPQYDAPLIPELQTALNGDHSRLPTLVSELRYWITQRRCEKTLQHLPATPHERLPLLHHPDHPMSKIGRHRMFVRLHKHPNVILIVEFKEKESTQCEIDCSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVLTLIEFDTFVITHGPFTSVDDQSEKFPQKRKAGGRQEPGSRRTKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLRLVQLPPPPGVDTQSASWLALLKRLLSVAIRVQGKATKSWMAEFVFYGSPLASSHPKEQGLRRPVYFQFDMGTAETVSKTVDALLSDWAQIVHLYTVVEDLAEYFRIEKYNLSNMVTIKSYSYSRLVLGYGPERGATVTVDWNSSDKAFRLIFGATNSCVNAHSLLREQLEAHLNRHRNLAQIVHLLHETYEPLISISKLPTIPQLGVHNQRPQVPVQTFTIMPQSPTLLRVAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFMGQTGISHLSRVLPQRSWAGAVPTLLTHEALDLLCSPSPHPQHLPGPELSPLERFLGCVYMRRQLQRFIQNEDCLAGIPSTEPGVVNFKVESLQCRVGLNPQHLQSLHIKVSPLPDHKEQWSAEEMQIIEKFFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELMPGLVQQQQMKWAVQWSLRTPPSATPIVPIGMAAVLVCRTKILFFLQITRIGGPYPSSMEAPSLVLPLVYDVSTNLTQLAEKRDPGPASATTAASLQLKRFAEFGVSHNECSLFPAVRDLLCTLSLPSESQAQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
Length1469
PositionTail
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.06
Grand average of hydropathy-0.236
Instability index58.38
Isoelectric point7.52
Molecular weight163602.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17751
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     198.09|      62|      78|     387|     464|       1
---------------------------------------------------------------------------
  333-  413 (90.40/61.77)	RLTVQVDTHepaRPLTVIHVPSLGSKECEIADRAIRSDLLsmerllvhtiyvrtrsRLTELKQELQTMLKDVECH..LQGSPA
  428-  491 (107.69/48.86)	QLLITVDTH...TGMLQCHVPQYDAPLIPELQTALNGDHS................RLPTLVSELRYWITQRRCEktLQHLPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     151.42|      20|      20|    1067|    1086|       2
---------------------------------------------------------------------------
  999- 1021 (26.01/ 7.89)	QREGGLRFHPPltppsgSNP.H..TP
 1067- 1086 (42.06/17.90)	PSPGGLLANSP......SNPLHVPSP
 1140- 1158 (30.14/10.47)	EALDLLCSPSP.......HPQHLPGP
 1426- 1438 (25.69/ 7.70)	PMPGGVVGLPP......Q.......P
 1444- 1455 (27.53/ 8.84)	QQPGG.....P......PQP...PYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.08|      10|      76|     173|     182|       4
---------------------------------------------------------------------------
  147-  156 (17.98/10.57)	LPACIRERIV
  173-  182 (17.09/ 9.67)	LNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.31|      40|      76|    1024|    1066|       5
---------------------------------------------------------------------------
 1024- 1064 (71.70/35.56)	PHPTmSQAG..QHQSFGSSPATSFNLASPPS.....LPPN..INPSPSML
 1089- 1137 (55.62/20.18)	IMPT.SSPGpcPNVPVGHSPAGSFMGQTGIShlsrvLPQRswAGAVPTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.62|      22|      95|    1160|    1181|       6
---------------------------------------------------------------------------
 1160- 1181 (41.01/33.11)	LSPLERFLGCVYMRRQLQRFIQ
 1258- 1277 (33.22/24.92)	LSGFGRMLNVPY..NVLKDFVQ
 1278- 1298 (34.39/26.15)	IMKLELMPGLV.QQQQMKWAVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.54|      13|      97|     511|     523|       7
---------------------------------------------------------------------------
  511-  523 (26.54/12.82)	GRHRMFVRLHKHP
  609-  621 (25.01/11.68)	GRQEPGSRRTKHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.39|      19|     726|     659|     694|       9
---------------------------------------------------------------------------
  248-  266 (34.57/14.09)	QVQYIHQVIQSRLVDNPQP
  659-  677 (31.82/27.74)	QVEANATALVLRLVQLPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.56|      20|     344|     276|     298|      13
---------------------------------------------------------------------------
  276-  296 (31.38/23.56)	FFCQSLQLEVLYSQTLRlCRD
  306-  325 (38.17/18.06)	EYTPGKCLSISYWRELT.CKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.65|      18|     564|      90|     108|      16
---------------------------------------------------------------------------
   58-   75 (29.93/14.59)	ERKVEIYNFSARTRQLFV
   91-  108 (29.73/18.21)	DKSAHIMAFLDKQSLLFV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17751 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SESQAQPSPAMQMHSPMPGGVVGLPPQPGAGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
2) VFRRRSQSEDDNPPSPITMDSDGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGIMPTSSPGPCPNVPVGHSPAGSFM
1411
957
1469
1112










Molecular Recognition Features






MoRF SequenceStartStop




NANANA