<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17747

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMASSETAQVSSLPLPPVQYINHYTDENIRRGRAPRPPPVIHDTYSMFGNTFNADDTIIRPLESQGIKRLYPQHFDRRRELRKLNHSLLVNFLDLLDLLVQCPDSPRRAEKVEDLSLLFIHIHHLLNEFRPHQARETLRVMMELQRRQRIETAQRFQKHLDKVMEILQQALQMLPDPSETDSKLLIPTELFDCMDTANQDESASESCNALDRLMCEIVDAL
Length220
PositionMiddle
OrganismCryptotermes secundus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Kalotermitidae> Cryptotermitinae> Cryptotermes.
Aromaticity0.05
Grand average of hydropathy-0.508
Instability index65.26
Isoelectric point5.71
Molecular weight25636.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17747
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.07|      23|      26|      82|     106|       1
---------------------------------------------------------------------------
   82-  106 (36.62/30.13)	KLNH.SLLvnFLDLLDLLVQC.PDSPR
  110-  134 (33.45/20.79)	KVEDlSLL..FIHIHHLLNEFrPHQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      20|      48|     150|     170|       2
---------------------------------------------------------------------------
  150-  170 (30.32/20.34)	ETAQRFQKHLDKVM.EILqQAL
  200-  220 (29.68/15.57)	ESASESCNALDRLMcEIV.DAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.15|      18|      26|      21|      44|       4
---------------------------------------------------------------------------
   34-   59 (23.02/21.91)	PRPPPVIHDTYsmfgNTFnaddTIIR
   60-   78 (28.12/12.19)	PLESQGIKRLY...pQHF....DRRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17747 with Med7 domain of Kingdom Metazoa
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