<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17742
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MPSDHPQTPQSPSTASSSAADQPRKQSASPHISHSLPTPAHSINGSMSSNSDIALEAAMLQDALHEEVSNKRKRDVEDNGDRDQKKVHVEDSRASIDDLHLDVGEKYLLCRTPHPARLPDLKQDLYAMYSLEDLAKSVARTNPDGSKAVKLRKTYKNHIKEHGVSGAFDSVKKEMDAPDTLLAMMLAPEEEWDAQFTRGKEFGKGLPETVMASMGKAFTMARGIIPKTSWNAAVLGELVSAPSQTESAKVMQNGNKAGAPQNPSIARTAKSDPPRPKRNLKKRTYGDSSFEGYGEGYVDDDAQETGYSGTDGEDRAGSRKRPKKTSQSHSFQNPPMRQNSYGPGMVGA |
Length | 348 |
Position | Head |
Organism | Meliniomyces bicolor E |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha bicolor.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.907 |
Instability index | 45.81 |
Isoelectric point | 7.20 |
Molecular weight | 37874.69 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP17742
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.54| 10| 34| 62| 71| 1
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62- 71 (17.44/11.34) DALHEEVSNK
97- 106 (18.10/12.01) DDLHLDVGEK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 106.99| 33| 37| 160| 194| 2
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160- 194 (49.95/40.13) KEHGvSGAFDSVKKEMDAPDTlLAMMLAPEEEWDA
200- 232 (57.04/36.79) KEFG.KGLPETVMASMGKAFT.MARGIIPKTSWNA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 115.53| 34| 294| 4| 39| 3
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4- 39 (57.48/30.67) DHPQTPQSPSTASSSAADQPRKQSASPhiSHSLPTP
301- 334 (58.05/26.01) DAQETGYSGTDGEDRAGSRKRPKKTSQ..SHSFQNP
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