<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17741

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTALQAWQSFFSRSLATRLDPSDFESYVQILSTKHPLSASRTSDLFLRPTETNAISLDPRVVRYVQVLLELKLVSVPSVLRALWKVSSFRDQNGHQDGQQKVAIGGETGEKTAGKTRDDGKRWNNSYIAEETLFYRLTKYISSGTVPHNTQEAVELVMVCVQWMRTVISVQHAAQEMLGLAQTHTAEMTAQNMALGTLIIAVVENGRVLHALGKGSVPKPVRKELKDTLANFVPLLLQSSPQSAARLELFRTQTILAIEPVDKKERAADKEIEEILEEGMALGVESMVVGDMPTMNSRAGLYVYLNSLLVGRPLIDDNAIFAYLHNRYQGDIQSTLIDLILAAFDVLANATFRNERAKSITILRSFLINKIPLLLATLSASLFPPLTSEYCVTEALGHVDTNAFPTLSVMFDESSTNNMFSDSVRQDFCFACCLHGLIEESSIETLLGDVPMQSLPAGGRSLKEDLVQQCLSDPERTEGLIDELERMDGNVGAVSQAITEVITRLCANKETMSLKSLCSQLARKPSALDVMLLFDKPISILQPLCELLDNWRYDEDQGEYQPVYEEFGLILLLVLSFTHRYGLSVVDLGIRTQDSFVAKLLNQGHLSRAMDDLTEQEQSHLDGWIRGLFEVGTLGDELMSSCPPQDFYLLVPTLFHHIVLACSTKNLTDDGLKSGLEYLVEPFLIPSLIPGITWLSSHLWESRGDANACVAILTALVTNSSSNTEASQMLTAILNIVAKNLEHSLRWLQRAEPSRQDVEPLSKALRPSLGWERRGASDHTELESWTSSPGGGLVVAVKQTIANLVQWSLNPGININPANYTHRQILVGVKMLSAKRILATIIEEVKSQTETGNGSIALDVASALICAPDPQSWDNGAPGIDVLGTEPRPLQRRMNLREALKNEAEAAPKTQKNDAFHAETVVRLYRKVEAQLQMPQQTLMSHDALDINQALDSAALDGAMAGVGSLDGMGSNNALGMGDGMGDSDLMHGLMGSGADLLDGFGPGELGDGLGF
Length1012
PositionTail
OrganismMeliniomyces bicolor E
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha bicolor.
Aromaticity0.06
Grand average of hydropathy-0.072
Instability index47.45
Isoelectric point4.98
Molecular weight110897.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17741
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.00|      21|      21|     966|     986|       1
---------------------------------------------------------------------------
  943-  966 (23.38/ 9.65)	DA.LDINQALDSAalDGaMAGVGSL
  967-  987 (40.57/21.91)	DG.MGSNNALGMG..DG.MGDSDLM
  988- 1006 (24.05/10.13)	HGlMGSGADL..L..DG.FGPGEL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.35|      35|      65|     781|     815|       2
---------------------------------------------------------------------------
  781-  815 (61.70/42.32)	ELESWTSSPGGGLVVAVKQTI..ANLVQ.W.SLNPGINI
  844-  882 (47.65/30.89)	EVKSQTETGNGSIALDVASALicAPDPQsWdNGAPGIDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.77|      29|      70|     666|     704|       3
---------------------------------------------------------------------------
  666-  704 (46.11/41.99)	NLTDDGLKSGLEYL..VEPF..........LIPSLIpgitwlsshlWESRG
  735-  775 (42.66/21.09)	NIVAKNLEHSLRWLqrAEPSrqdveplskaLRPSLG..........WERRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.85|      20|      71|     532|     551|       5
---------------------------------------------------------------------------
  505-  524 (31.09/20.55)	LCANKETMSLKSLCSQLARK
  532-  551 (35.76/24.82)	LLFDKPISILQPLCELLDNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.64|      25|     140|     225|     254|       8
---------------------------------------------------------------------------
  225-  254 (37.74/34.23)	LKDTLANFVPLLLQSSPQSaarleLFRTQT
  363-  387 (42.89/27.08)	LRSFLINKIPLLLATLSAS.....LFPPLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17741 with Med5 domain of Kingdom Fungi
Unable to open file!