<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17736

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDEMDMEDLFGDGAGLSLPSRPPSKELYQRLDELRGSGCCQGIAWSKWGSIAAIASNGAALELRNLRCHPENGTWALSEPTVTPNFSSALDGGPLKHLSWSPTGSDLAVIDAAGRITILAVFSSLNKPSLSRACGGDPADDLHGIVGCYWLNIAPYPPNRPTILHGPGVKDGPNYKYEAQQGPVLGPCHPSPSKSAFVCLTTNGLLRLLWPQNTGKWCESHSELESIVSSDDLITHAAICPDKTGTLLIAFATTSKQLRTVRALIEWNPTKVDKVNSAQWALNPTIKTRHLAVTSWVHDIPSDTVNASHMESSMVQLSHLEFLPPCGDAAGRMAPPTILAVRSHLPGSTSHYNQDVHTTVDRWEVREKPQTIHPAFEQLSSRRNSVGSQPGPVVYLKKLESFTVNKIIIALETMNIGKVLFLAYADGSVEYRDRLTMTETFNDGDLDRVWHLSQIGFSYPNDDPCLQVALSPSYCSLVQIRNDGKVKWKQLDYQLADIGSSMEDGLYAGVVAALSLSCATAVMRNVNYDDLLATANKHATARKSEFAYDWLTDLSRILKVHMDYSEESHHDVLVRNTTIQLCLCIQNSLGFKGEFNPRTFSGKFAWLVLQLRNIVVLVTMAANLNVPQSGPESDKKSPLEDPEVINSLAGSVRWVLDLLAWLTDTLLTLPSTLPPTIDLTKASNLPLPELLAHLHSTNTISLHLLLSSPTRGFLTAICRRLQHLDYIARKAIVYPGVNNTPNPQNVNQNSQNQTAAPSPALRAAYLQIATLTSDTILRIKTMETLLGSLASLVKNAYASNNPPLSGSQPAEKARNALEIKMLFGGSFPDAFKSVIVELFKKEGLLDAVKEEIEPAKLFFADFTMLEVDEDAVSVGKRRALGRTMDCFQKRWLLNPEKILLSPSSSAAAAAAAAATGAEGSSSQTGTANASLGAAQDGSGVGSGGLMGAGGRQGARWRRCARCAAVMEDVLTQRVALQWLVMQQRRCFCSGYWDTLAPGEALA
Length1003
PositionTail
OrganismMeliniomyces bicolor E
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha bicolor.
Aromaticity0.07
Grand average of hydropathy-0.141
Instability index42.85
Isoelectric point6.26
Molecular weight109008.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17736
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.90|      25|      45|     636|     660|       1
---------------------------------------------------------------------------
  636-  660 (42.62/26.45)	KKSPLEDPEVINSLAGSVRWVLDLL
  682-  706 (42.28/26.18)	KASNLPLPELLAHLHSTNTISLHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     239.15|      52|     115|      69|     122|       2
---------------------------------------------------------------------------
   17-   59 (37.76/13.67)	.........LSLPSRP..PSkeLYQRLDelrgSGC.CQGIAWSKWGS.IAAIASNG.....
   69-  120 (91.54/45.87)	CHPENGTWALSEPTVT..PN..FSSALD....GGP.LKHLSWSPTGSDLAVIDAAGRITIL
  124-  154 (30.17/ 9.43)	........................SSLN....KPS.LSRACGGDPADDLHGIVGCYWLNI.
  156-  210 (79.69/34.87)	PYPPNRPTILHGPGVKdgPN..YKYEAQ....QGPvLGPCHPSPSKSAFVCLTTNGLLRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.45|      32|     115|     466|     499|       3
---------------------------------------------------------------------------
  466-  499 (53.38/43.22)	CLQVALSPSYCSLVQIRN.DGKVKWkqLDYQLADI
  583-  615 (55.07/37.81)	CLCIQNSLGFKGEFNPRTfSGKFAW..LVLQLRNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.33|      54|     337|     504|     559|       4
---------------------------------------------------------------------------
  504-  558 (84.67/76.53)	EDGLYAGV...VAALSLSCATAVMRNVNyDDLLATANKHATARKSE.FAYDWLTDLSRI
  842-  899 (81.66/61.67)	KEGLLDAVkeeIEPAKLFFADFTMLEVD.EDAVSVGKRRALGRTMDcFQKRWLLNPEKI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17736 with Med16 domain of Kingdom Fungi
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