<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17735

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGEYLTNVLSSNIFASIIYEYFEPQSLPAGTARKYLQRLEAGWRQEGKLVYCDPFRDGIWIFQGTANASNNTISRDADAPSVAEAYSAGLVQRDKGTYEPASLVRSKQAISNNTSTPSSGSSPSSSLDSTIRNAQALNARSIQTNSALGVIQEPSTTSPGARSALGADTPTSLKDIHELFISAVLGSIVYFLCRDHGFVPLNSRTLILTPLKPKCKGYFTNKHTQVTNAIELATLDISLTSLGTLVVKARSNLARGLQALLENSGSASVSSKLAPGAALWLAPGGNAAKFYSYTDEKNLSTSLSISQIQAGAAEQRPSNVNSLTIKSWQSKCLEWLSTKGLNASVLEDGGWLFVQVVGSYPPYLNGEFQGLPVADELALVPWPALLCFQTSSIGPRSLQVIHNGPTGPRDSLAFAEDWFTGKDERAMAMSKRQKDRQAAETLSKEQADVEARALQSITYSPATLRRGSNAGAMYPTPPDAPHHPIGATPSFDGTASTPGNPHPFASHDPGTASQVTSGANDADADLWGSSVKKERNNSGMAFNDNENDNPNMFGDLGDDIFGTDVTDADFSFFDEPDAVLPGLKNESPVVSLPVSQEASFSEETAVSNPTNLQVLDPPDTTMLDVNISESRMDELPPPSSEAAVLKNKIETGEVIKTETIDTNKNRPTPIILPLDKETVFKRLVREPSGNTRQKQPRRASLFDRVDFEDALLSVNEKYGAHGQFNYSAKLKRKQASSQIELPQTQYLPSQQRIQEKGQELRNIAHILTKNELDTPINSREPMDYLMDSDGGSQVSEQDGTSHTTSDQSLLPNHGLKRKWEKEDGDDMASTFDALAMELEHSASTPQSISGSQIPLLEADPADWALATYFTSPEPDIESNTLSDLERVATAQILADQAVSGTLQIPKTAGNVTPFTSKSTFTTKELISSVARAAKSCLREINGCTMRSFLEIQGIPVLNQGLRLPPRPIVNPRGPNGIDAARANNPFPIPPPQLEVRRADTKLSVLPAAITFWENLGLGPSKGPKDVSAVCVYPNFDGVASNAEIFLDQMRSVYECSRLGSHDKLVTKDLTNGLMPFIVESPQQNKLHHLSALKDVASRLSRILSSVVMEEKNFVVYFIYPTDNSTLLVHICSAFQHLFNLYRKALSERRVATANELVLQLIPLDLVSSPTSLAVPLPSEYFRLAMEVYDRCIDFVSSSSTPAIMLEQPLPKAIDFKLNATPSASLLQENTCLHVGYAQSIDDRWITATWTDNRGTQQMTASYCLGRKNEPISMPFSEVANEIWGTTLNFIASKKIHWRIMIARVGVMDPSEIDFWTGLASTESEAQVSLTLITVQTDPSLRLLPASITLAPNTNSATSVATPVSTPQALQSSIVSPGDAATPAKEIASAATPVDGPVEPDSDARLIDSTDQSWGAVLSHRLNNSNSLMELNPALISGYLLKRGGVHSDDPPIIMEVNILYSEVVGNPRTFHEGLLREILGYYRGLGTLARVRGLVDSVGDVRPWHIAAAEKAVKALYMLM
Length1522
PositionKinase
OrganismMeliniomyces bicolor E
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha bicolor.
Aromaticity0.07
Grand average of hydropathy-0.286
Instability index43.65
Isoelectric point5.20
Molecular weight165236.94
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17735
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.92|      16|      32|    1310|    1341|       1
---------------------------------------------------------------------------
 1008- 1023 (30.39/ 7.41)	PAAITFWENLGLGPSK
 1311- 1326 (29.54/30.34)	PSEIDFWTGLASTESE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.48|      20|      32|    1166|    1185|       2
---------------------------------------------------------------------------
 1166- 1185 (36.84/21.84)	DLVSSPTSLAV....PLPSEY.FRL
 1195- 1219 (26.65/13.50)	DFVSSSSTPAImleqPLPKAIdFKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.61|      16|      33|    1353|    1368|       3
---------------------------------------------------------------------------
  161-  174 (19.86/ 7.42)	PGARSALGADTPTS..
 1353- 1368 (30.35/15.36)	PNTNSATSVATPVSTP
 1384- 1398 (25.40/11.61)	PAKEIA.SAATPVDGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.37|      22|      40|      71|      92|       5
---------------------------------------------------------------------------
   71-   92 (36.51/19.36)	SNNTISRDADAPSVAEAYSAGL
  108-  129 (36.85/19.61)	SKQAISNNTSTPSSGSSPSSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.29|      31|      40|     565|     604|       6
---------------------------------------------------------------------------
  565-  595 (53.76/40.57)	TDVTD.ADFSFFDEPDAVLPGLK.NESPVVSLP
  606-  638 (44.53/18.14)	TAVSNpTNLQVLDPPDTTMLDVNiSESRMDELP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.59|      17|      31|     501|     530|       7
---------------------------------------------------------------------------
  479-  498 (28.11/23.99)	PPDAPHHPIGATpsfDGTAS
  511-  527 (29.48/12.61)	PGTASQVTSGAN...DADAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.16|      95|     603|     302|     407|       8
---------------------------------------------------------------------------
  302-  407 (148.46/147.95)	STSLS......ISQIQAGAA....EQRPSNVNSLTikSWQSKCLewLSTKGLNASVLEDGGWLFVQVVG.SYPPYLngEFQGLPVADE.LALVPWPALlcfqtSSIGPRSLQVIH.NGP
  880-  987 (139.70/104.85)	SNTLSdlervaTAQILADQAvsgtLQIPKTAGNVT..PFTSKST..FTTKELISSVARAAKSCLREINGcTMRSFL..EIQGIPVLNQgLRLPPRPIV.....NPRGPNGIDAARaNNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.26|      25|      38|    1222|    1246|      10
---------------------------------------------------------------------------
 1222- 1246 (44.29/28.89)	TPSASLLQENTCLHVGYAQSIDDRW
 1261- 1285 (44.97/29.45)	TASYCLGRKNEPISMPFSEVANEIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.87|      34|      40|    1058|    1095|      11
---------------------------------------------------------------------------
 1058- 1091 (57.44/34.08)	SRLGSHDKLVTKDLTNGLMPFIVESPQQNKLHHL
 1099- 1132 (54.43/37.04)	SRLSRILSSVVMEEKNFVVYFIYPTDNSTLLVHI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17735 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERAMAMSKRQKDRQAAETLSKEQADVEARALQSITYSPA
2) GQELRNIAHILTKNELDTPINSREPMDYLMDSDGGSQVSEQDGTSHTTSDQSLLPNHGLKRKWEKEDG
3) PGLKNESPVVSLPVSQEASFSEETAVSNPTNLQVLDPPDTTMLDVNISESRMDELPPPSSEAAVLKNK
4) RRGSNAGAMYPTPPDAPHHPIGATPSFDGTASTPGNPHPFASHDPGTASQVTSGANDADADLWGSSVKKERNNSGMAFNDNENDNPNMFGDLGDDI
426
759
583
467
464
826
650
562










Molecular Recognition Features






MoRF SequenceStartStop




1) FKRLV
682
686