<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17733

Description RNA polymeras-like protein II mediator complex component Srb8
SequenceMTSRPSVGRQGPQRSLSSTNALQRPPPHRTLSQQFSSSSPTRRGNEGFVDLTFDESVLARHGPRVGTSRLRVEISKDSGPSEMVESPKPISDAAPTWRPSLPPRGRPQLHFDVPSVSNLSPHPAQDGGQNEVTIKPMPLPVRPGQHAPPSSEKSRAAPSNAAKKDARPKPYILEVPTAAPHYSPNGHTDFFPWTGNHPEDQFSEPVIRHGFFDKAQMTQNETGSAKPSIFPALKHKSGLQTLSALFTSVLAQRRAHGQITSASTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAVWLAKCVGANELRSFRRKGVSGTFAMGGEAKWIRDFTVCVEQFMESILATCGEKDFKTRISYAIRLATHFYAEYLLDREHYMDWLVTSLENSPQAKLPMWLLITQVYWKDLLKYRKYGRRLSAALLSQLARTLNHLDRDILAPLSDRLRVLLKGIVISNSESFVGPKVWAKHRDVIMSDLDLDDERFMSILAALDLRNSRLNASGTEKTLTARRRLLYVLDGTLIRPLTNETARQCWEIDEDKAMLSRTILEWSSSSYRPGNAKIYVAARIMRSWIKFGADVTSAVLDFLDSAVCNSGRRNSAFYHLVSELARSEHFSTPRYLEWLIARGGLYNAKDVASDGPCATRLLAELPTNNLSESIAELRATLLSRAGFLVEEEEDQTNDLMTFMNQNLPGMQATVDDKLESQSLDVNLASISSEASRTTKSELGLWLRQKVRLQMAQPTIPPFDDWDDSPMKGGTSAITSSDFNTVRQYLELIDDYSMLADVLKIVTSSNDAEVLASCVDTLDLHIEVFSAIGALRGLFDILVTRLRALSDEIDSIPRVLLVTLSDLASRLPEQRMVAQQLAQELARSDRKTAADACSPVSDHMALVQTSEADFTDEIEKVLASGNSMDQATLERLFQRIILRLEESWEKSQEQRSCGLLLTRLRTFDAQQFDALMTAWIKRLVPRQNRPTMLEVFGPLISFGCLALRDVIVSSGATETMENPQDSSTAHEALGLLVTSFCLPETMTIEERYRLRIKQAHMQKDHPVEVLNVVRLVFGEPIDLDERSSSLDRKILQSADFHELLQVLVLSDTHRFIDNLVMPLLQSSTPDAAVTINRCVDKFLLAGNENETITTEVLLNLADDLSLPFCQVKLAAMFRRDDTVMEGADDGQAEDLEAFDRAIESAVATGKTTWASIVPLLDASIAQRLRQRAEARFLALFPSPKATGGEDTMQNRVVHAENLLHIIDATAYSASATNTSVGATNLACDIVAVLNGLWLLLAKSQSRDIKDAIMSKWLPLLLSFTTIRIPAFEATKPGHESRAKAVLALAAIFLQLQALDIATDEIKNLIEQTFDLALYLVDPLPEDMRQQCIRNLRDAASSAQISYLFSFTPNPTEWLVLSQKERTLPPPGAGVAERATEKEKLVPFSLRRWEMLGEPTPNVGENDTSLSLTLFGARRG
Length1487
PositionKinase
OrganismMeliniomyces bicolor E
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha bicolor.
Aromaticity0.07
Grand average of hydropathy-0.249
Instability index46.80
Isoelectric point6.13
Molecular weight165631.96
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17733
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     709.73|     220|     240|     284|     523|       1
---------------------------------------------------------------------------
  284-  521 (346.34/343.12)	DLANPTISLRRlsrsiphgiRGKVLLDQSLSKNIPIE..RAVW........LAKCVGANELRSFRRKGVSGTFAMGGEAKWIR...DFTVCVEQFMESILATCGEKD..FKTRISYAIRLAT.HFYAEYLLDREHYMDWLVT..SLENS...PQ..AKLPMWL.LITQVYWKDLlkyRKYGRRLSAALLSQlARTLNHLDRDILAPLSDRLRVLLKGIvisnsESFVGPKVWAKHRDVIMSDLDLDDERFMSILAALDLRNS
  526-  758 (314.46/268.28)	SGTEKTLTARR.........RLLYVLDGTLIRPLTNEtaRQCWeidedkamLSRTILEWSSSSYRPGNAKIYVAARIMRSWIKfgaDVTSAVLDFLDSAVCNSGRRNsaFYHLVSELAR.SE.HF......STPRYLEWLIArgGLYNA...KDvaSDGPCATrLLAELPTNNL...SESIAELRATLLSR.AGFLVEEEEDQTNDLMTFMNQNLPGM.....QATVDDKLESQSLDVNLASISSEASRTTKSELGLWLRQK
  895-  976 (48.93/25.42)	...........................................................................RSDRKTAA...DACSPVSDHM..ALVQTSEAD..FTDEIEKV..LASgNSMDQATLER..LFQRIIL..RLEESwekSQ..EQRSCGL.LLTRLRTFD.........................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     226.65|      63|      88|      76|     140|       4
---------------------------------------------------------------------------
   76-  140 (110.24/78.12)	KdSGPSEMVES...PKP....ISDAAPTWRPS.....LPPRG.RPQLHFDVPSVSNLSPHPAQdGGQNEV.TIKPMPLP
  155-  231 (83.01/50.07)	R.AAPSNAAKKdarPKPyileVPTAAPHYSPNghtdfFPWTGnHPEDQFSEPVIRHGFFDKAQ.MTQNETgSAKPSIFP
  233-  269 (33.41/14.53)	........LKH...KSG....LQTLSALFTSV.....LAQR....RAHGQITSASTFKPPP..................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17733 with Med12 domain of Kingdom Fungi
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