<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17732

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMENGRNGSHTNHDRDQRPNGVNGANYAPERNQEKGKGKADPQQNMTPISPTIPHGLNGSFMDASQHQNGGGNAIPHDMQDRINQLPPEIAHITQGYLPLSRLLSRLAQKTHSDLSSTILELAQMPVPSSAVNGNASHITTVDDNSAENLAKKLRMLKFAQDAHTEWTKALVITGWSRRAEDVSRTIDLKIHLDDQIQFYENAVYELGEVKKGLIHAHLPNPDLPTALEVLTTGKASWMPDLGYIQPPPLTAKEILKSLENLNTLLSIRLNLHDYDSIPLQFKDFTIKSGRVTFKVAGEFEIDLTIADEDPEAQFWFIDFRFMFWPSVPILAPKIRYHIESRVNEALAKDGLTGCYKYLHELALTHKISEFRKQAIDLARAKWIDALKVEALNRALSVQYWLDRYGPKGPRSWIILGVHSGKRKDGRPDSKTTSRLFVRWFRDSKEVPDVDVQFDTVNITTQSLLKTVIAKHVSHILTSIHDTLAAKPLFANRELALSLSVSLTEPAESKLEVQLTNEQHLTVKIEPITGRFVFSPASRVTTEWENYLNVRTINPALDGHTYIERLRRQLLAEEIVNRALSVGWIIANPGLKPDVLQPFVPKGPFPPTILWFRRAGWLEDWCIAVIMGESGEQWLLFETADAPANTSSSNVSQSRRIMSSIQVPSKLASPVPSYEYLLTLNIFAAALVSHYCNLRTLHGKRAAHMLRPSRPSKAVTLPSIYVRLSELLVSKGKSARTGLPWARDVVRLTFQGLELLPPTSADTIVSVVENQTPGDIVLRRPTSQEIAVMITEARMSVPEPNGPNVLININEKVDKDIAFDPESGSFAFRLRSRIGESVIPDLVERLVRVERLVEFIQVLQKHEKALKCESVSLGKIVFTYGNISASHGLDAMELDAHPYKATVDFSAMENNMTLVLERGNPHLRISDFLAKVLNGSEGLDGVASILPLTLPVLRGLDGIENAWTPAPDTDKGEVFVNVRAIDWYMIRYNLKQSVPAPESPPRIRKVMLEVKLQHRRGDPWWYIKRSVKRSDTASRINKETDDIDVALKPVWTSEGPGWRGMRVSAVAQINGVEELLGKLDEVIRNLPVPDDDAPAAAPATVPTAAPPKQHARPQAPKQQQRQQQPTPNQGRIQGQSQGRNKTFKQEIVEID
Length1155
PositionTail
OrganismMeliniomyces bicolor E
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha bicolor.
Aromaticity0.07
Grand average of hydropathy-0.337
Instability index45.04
Isoelectric point8.28
Molecular weight129151.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.31|      14|      19|       8|      21|       1
---------------------------------------------------------------------------
    8-   21 (27.73/18.84)	NGRNGSHTNHDRDQ
   24-   37 (26.58/17.74)	NGVNGANYAPERNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.31|      15|      19|      45|      59|       2
---------------------------------------------------------------------------
   45-   59 (29.85/16.49)	DPQQNMTPISPTIPH
   67-   81 (28.46/15.40)	DASQHQNGGGNAIPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.94|      43|     192|     372|     430|       3
---------------------------------------------------------------------------
  372-  430 (58.99/63.59)	ISEFRKQAidLARakwidalkvEALNRALSVQyW...........LDRYGPKGPRSWIILGVhsgkRKDG
  567-  620 (74.94/40.16)	IERLRRQL..LAE.........EIVNRALSVG.WiianpglkpdvLQPFVPKGPFPPTILWF....RRAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.54|      13|      15|     672|     684|       4
---------------------------------------------------------------------------
  672-  684 (23.72/15.00)	ASPVPSYEYLLTL
  689-  701 (23.81/15.08)	AALVSHYCNLRTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.14|      18|      19|     936|     953|       7
---------------------------------------------------------------------------
  936-  953 (29.83/15.46)	VLNGSEGLDGVASILPLT
  956-  973 (33.31/18.06)	VLRGLDGIENAWTPAPDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     222.17|     101|     665|     176|     292|      12
---------------------------------------------------------------------------
  176-  238 (45.47/40.04)	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VI............................................................................................................................TGWSRRAEDVSRTIDLkIHLdDQIQFYENAV....YELGEVKKGLihaHLPNpdlPTAleVLTTG
  239-  292 (52.31/36.35)	KASWMPDLGYIQPPPLTAKEILKSLENLNTLLSIRLNLHdydsipLQFKDFTIK....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  842-  885 (35.06/13.54)	......................................................sgrvtfkvagefeidltiadedpeaqfwfidfrfmfwpsvpilapkiryhiesrvnealakdgltgcykylhelalthkisefrkqaidlarakwidalkvealnralsvqywldrygpkgprswiilgvhsgkrkdgrpdskttsrlfvrwfrdskevpdvdvqfdtvnittqsllktviakhvshiltsihdtlaakplfanrelalslsvsltepaesklevqltneqhltvkiepitgrfvfspasrvttewenylnvrtinpaldghtyierlrrqllaeeivnralsvgwiianpglkpdvlqpfvpkgpfpptilwfrragwledwciavimgesgeqwllfetadapantsssnvsqsrrimssiqvpsklaspvpsyeylltlnifaaalvshycnlrtlhgkraahmlrpsrpskavtlpsiyvrlsellvskgksartglpwardvvrltfqglellpptsadtivsvvenqtpgdivlrrptsqeiavmitearmsvpepngpnvlininekvdkdiafdpesgsfafrlrsrigesVI............................................................................................................................PDLVERLVRVERLVEF.IQV...LQKHEKALkcesVSLGKI...................VFTYG
  888-  935 (58.47/28.21)	SASHGLDAMELDAHPYKATVDFSAMENNMTLVLERGNPH......LRISDFLAK....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1060- 1100 (30.86/10.35)	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................vlngsegldgvasilpltlpvlrgldgienawtpapdtdkgevfvnvraidwymirynlkqsvpapespprirkvmlevklqhrrgdpwwyikrsvkrsdtasrinketddidvalkpvwtsegPGW..RGMRVSAV........AQINGVEELL....GKLDEVIRNL...PVPDddaPAA.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.86|      12|      16|     463|     475|      13
---------------------------------------------------------------------------
  463-  475 (14.70/16.75)	ITTqSLLKTVIAK
  480-  491 (20.16/15.84)	ILT.SIHDTLAAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17732 with Med14 domain of Kingdom Fungi
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