<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17726

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDEMDMDDLFGDGAGLSLPSRPPSKELYQRLDELRGSGCCQGIAWSKWGSIAAIASNGAALELRNLRCHPENGTWALSEPTVTPNFSSALDGGPLKHLSWSPTGSDLAVIDAAGRITILAVFSSLNKPSLSRTCGGDPADDLHGIVGCYWLNIAPYPPNRPNIFHGPGVKEGSNYRYEAQQGPVLGPCHPSPSKSAFVCLTTNGLLRLLWPQNTGKWCESHSELESIVSSDDLITHAAICPDKTGTLLIAFATTSKQLRTVRALIEWNPTKIDKVPQAQWPLNPTIKTRHLAVTSWVHDIPSDTVNASHMESSMVQLSHLEFLPPCGDAAGRMAPPTILAVRSHLPVSTSHYNQDVHTTVDRWEVREKPQTIHPAFEQLSSRRNSVGSQPGSVVFLKKLESFTVNKIAIALDTMNLGKILFLAYADGSVEYRDRLTMAETFNDGDLDRVWHLSQIGFSYSDDDPCLQVALSPSYCSLVQIRNDGKVHWKQLDYQLGDIGSSMEDGLYAGVVAALSLSCATAVMRNVNYDDLLATAKKHATAQFAYDWLTDLSRILKVHMDYSEESHHDVLVRNTTIQLCLCIQNSLGFKGEFNSRTFSGKFAWLVLQLRNIVVLVTMAANLNVPQSGPESDKKSPLEDPEVINSLAGSVRWVLDLLAWLTDTLLSLPTTLPSTIDLTKASNLSLPDLLAHLHSTNTISLHLLLSSPTRGFLTAICRRLQHLDYIARKAIVYPGANSPNPQMANQNSQHQPTAPSPALRAAYWQIASLTSGTILRIKTIETLLGSLASLIKTAYASNQPPLSGSQAAEKARNALEIKMLFGGSFPDAFKSVIVELFKKEGLLDAVKDEIEPARLFFADFTMLEVDEDAISVGKRKALGKTMDCFQKRWLVNPEKKLLTSSSAAGSGVEGSSQTANTNLGTAQDGGAVGSGGLMGAGGRQGARWRRCARCAAVMEDVLTQRTALQWLVMQQRRCFCSGYWDTLAPGETLA
Length989
PositionTail
OrganismHyaloscypha variabilis F
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha variabilis.
Aromaticity0.07
Grand average of hydropathy-0.152
Instability index40.94
Isoelectric point6.31
Molecular weight107870.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17726
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.63|      32|     112|     466|     499|       1
---------------------------------------------------------------------------
  417-  443 (42.30/23.05)	LGKILF..LA..YADGSV..........EYRDRL.....TMAETFN
  444-  483 (33.41/21.71)	DG.....DLDrvWHLSQI.gfsysdddpCLQVALSPSyCSLVQIRN
  484-  526 (44.92/29.17)	DGKVHWkQLD..YQLGDIgssmedglyaGVVAALSLS.CATAVMRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.79|      26|     108|      63|     103|       2
---------------------------------------------------------------------------
   17-   48 (40.93/14.96)	LSLPSRPPSkeLYQRLDelrgSGCCQGIAWSK
   78-  103 (48.86/52.08)	LSEPTVTPN..FSSALD....GGPLKHLSWSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.93|      12|      19|     645|     656|       3
---------------------------------------------------------------------------
  645-  656 (20.55/11.82)	SLAGSVRWVLDL
  666-  677 (20.39/11.66)	SLPTTLPSTIDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.51|      73|     120|     192|     273|       4
---------------------------------------------------------------------------
  192-  273 (114.13/85.78)	SPS........KSAFVCLTTnglLRLLWP..QNTGKWCES.....HSELESIVS..SDDLitHAAI....CPDKTGTLLIAFattsKQLRTVRALIEWNPTKI
  301-  394 (100.38/57.07)	IPSdtvnashmESSMVQLSH...LEFLPPcgDAAGRMAPPtilavRSHLPVSTShyNQDV..HTTVdrweVREKPQTIHPAF....EQLSSRRNSVGSQPGSV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17726 with Med16 domain of Kingdom Fungi
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