<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17723

Description RNA polymeras-like protein II mediator complex component Srb8
SequenceMTSSLGRQAPQRSLSSNALQRPPPNRTLSAQFSSPTRRGNEGFTDLTFDTDAVRYGTRVGTSRLRVEISKDSKVSEMVESPKPTPDATSPWRPSIPPRGRPQLHFDVPSVSNPSPRPAQDGGQNEVTIKPMPLPTRPGQHASLFVDKSRAAPSTAVKKDVRPKAYILEVPAVAPRYPPNGHADFFPWTGNHPEDQFSEPVIRQGYFDKAQMTQNEMGSAKPSIFPALKHKSGLQTMSALFTGVLAQRRAHGQITSASTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAVWLAKCVGANELRSFRRKGVSGTFAMGGEAKWIRDFTVCVEQFVESILATCGEKDFKPRIGYAIRLATYFHAEHLLDREHYMDWMVSSLENSPQAKLPMWLLITQVYWKDLLKYRKYGRRLAAALLNQLAETFDHPDHDILAPLSDRLRDLLKGIMISNPDSFVNPKVWVKHRNIIMNGLGLDDERFVSIITTLDRRNSRLEATGTEKTLSARRRLLHILDATFIRPLTNETAQQCWEVDEDKAMLFRTILEWSSSSYRPGHAKIYVAARIIRSWANFGADVTGAILDFIDSSVCESGRNRAAFYHLISELARSEHFSTPRYLQWLIARGGLYDITDVAPDGPCATRLLAELPTHNLSESISELRDTLLSRAGFLIDDEEDQVSDLMSFINQSLPGMQANVDDELEAQRLDVNLFSLSSGISRTIKSELGLWLRQKVRLQMEQPTIPPLDDWDDSPMRGGTSAITPSDFNTVRQYLELIDDYSMLADVLRVVASSNDAEVLASCADTLDLHVEIFSAIGALKGLFDILVARLRTLTDEVDSIPRVFLMALSDLASRLPEHKTVAQQLAQELVRSDRKTAADACSPVSDHMALVQTSEMDFTDEIEKVLASGNSMDQATLERLFQRIALRLEDAWEKIPEQQRSCGLLLTRLRTFDAQQFDVLMTTWIKRLALSQNRPTMMQAFGPLISFGCLALRDVILSSNPTEAMGSSQFPSTSHEVLELMVASVGLPAALTIEEGYRLRIKQAHMLKDNPAEVVDVIRRVFGETSSPYGRSSSSDAGILQSESFHELLQTLVLWDTHRFIDNLVMPLLQSSAPKAVVAINSCIDKFLLVGDETAIITTEVLLNLADDLSLPFCQVKLASMFKRDETIMEGVDYGQAEGLEAFDRAIESAVAAGKTTWASIVPLLDPSIAQRLRQRAEARFLALFPSPRATSSEDSMHNRIVHAENLLHIIDATAYSVSATTTSAGTNNLACDMVATLNGLWLLLANSQSREIKDTIMSKWLPLLLSFTTIHIYSFEATKAGHESRAKAILGLAAIYLQLQALEPATDETKSLIEQTFDLALCLVDVLPEDMRQQCIRSLRDTAASPRISYLFSYAPNPTEWLVLSQKERILPPPGAGAAERTVEKEKLAPFSLRRWEMLGEPTPNVGENDTSLSLTLFGARRG
Length1482
PositionKinase
OrganismHyaloscypha variabilis F
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha variabilis.
Aromaticity0.07
Grand average of hydropathy-0.219
Instability index48.25
Isoelectric point6.08
Molecular weight165139.63
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17723
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     607.78|     199|     240|     548|     787|       1
---------------------------------------------------------------------------
  401-  481 (51.20/16.14)	..................................................................MVSSL..ENSPQAKLPMWL..LITQVYWKDLLKYRKYGrRLAAALLN.QLaetfdhPDHDILAPLSDrLRDLL....KGIMISNPD.......SFVN............................................................................................................
  560-  785 (296.24/296.15)	AMLfRTILewssssyrpghakiyvaaRIIRSWANfgADVTGAILDFIDSSV...CESGRNRAAFYHLISEL..ARSEHFSTPRYLqWLIARGGLYDITDVAPDG.PCATRLLA.EL......PTHNLSESISE.LRDTL.LSRAGFLIDDEEDQVSDLMSFINqSLPGM.QANVdDELeAQRLDVNLFSLSSGISRTIKSeLGL...................WLRqKVRLQMEQPTI....PPLDDWDDSPMR......GGTSAITPSDF
  799- 1028 (260.35/168.50)	SML.ADVL..................RVVASSND..AEVLASCADTLDLHVeifSAIGALKGLFDILVARLrtLTDEVDSIPRV..FLMA...LSDLASRLPEH.KTVAQQLAqEL...vrsDRKTAADACSP.VSDHMaLVQTSEM..DFTDEIEKVLA....SGNSMdQATL.ERL.FQRIALRLEDAWEKIPEQQRS.CGLlltrlrtfdaqqfdvlmttWIK.RLALSQNRPTMmqafGPLISFGCLALRdvilssNPTEAMGSSQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     205.78|      53|    1130|      71|     126|       2
---------------------------------------------------------------------------
   21-   64 (54.39/24.59)	...........RPPPNRTLSAQFSSPTRrgneGFTDLT.FDTDAV.....RYGTRVGTSRL
   71-  126 (92.34/53.37)	DSKVSEMVESPKPTPDATSPWRPSIPPR....GRPQLH.FDVPSVsnpSPRPAQDGGQNEV
  138-  180 (59.05/27.31)	GQHASLFVDKSRAAP..STAVKKDV........RPKAYiLEVPAV...APRYPPNG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.58|      40|    1168|     261|     308|       3
---------------------------------------------------------------------------
  261-  308 (52.56/67.84)	PPPRVTVTDTKREmwlKDLANPtISLRR...LSRSIPHgiRGKVllDQSLS
 1431- 1473 (67.02/49.46)	PPPGAGAAERTVE...KEKLAP.FSLRRwemLGEPTPN..VGEN..DTSLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17723 with Med12 domain of Kingdom Fungi
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