<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17717

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSTMDPGEYLTNVLSSNLFASISYEYYEPQSLPAGTARKYLQRLETSWRQEGKLVLCDPFRDGVWIFQSTGNASSNTALRDTDPSSAVEAYSAGLVQRDKGLYEPASLARSKPAVSNNAGTSSSSSSPSSSLDSTVRNAQALNARAIQTNLALGVMQEPPTPSPGARSAGADTPTSLKVIHEYFISAVLAVLVYFLCRDHGFVPLNSRTLILTPLKPRCKGYYLSKHAQFTNDIELATLDISLTSLGTLVVKAYSNSAPGLQMLLENSSSSNTPSKLAPGASLWLAPGGNAAKFHSYNDEKNLPTSLPIAQIQASATENRPNGISSLTIKSWQSKCLEWLSTKGLNTSTLEDGGWLFVQVVGSHPPYFNGEFQGLPVSEELAIVPWPTLLCFQTSSIGPRYLQAMSNGPIGPRDSLSFAEDWFTEKDERAHTISKRQKERQAAEILSKEQADVEARALQAITYSPATLRRGSNAGAMYPTPPDAPHHPIGATPSFDGTVSTPGNPHPFVSHDPGTANQVTTVANDGDADLWGSSGKKERNNSAMAFNDNENENDNSNMFEDLEGDIFGNDITDADFSFFDEPDTVVEPDPKPESPIVPLQAPQEASLLKETEFVKLPELPVLDAPDTTMMDVDISEIQVGEVSAPLLEAEVVENHTEIGKVSSPKIADTQKNPTTSINLPLDKEMVFKRLQRDTSRLVGSTNQKQLRRASLFNRVDFEDALLSVNAKYGAHGQFNFNSKLKPRQATIKTELPQTRYLSSRRRIRENGQELGHIARILNQNELDQPTDSREPIDYLMDSDGASQVSEQDDTSHGTNDLSVLPHPGLKRKWENEDGDDMTSTFDALAMELEHSASTPQSISGSQIPLMEADPADWSLTTYFTSPEPDIQSNILSDIERIATAQILADQAVSGTLRIPRSAGSETPVTSNSIFTGRELISTVASAAKSSLRELNSCTMRSYLEIQGIPALNQGLRLPPRPIVNHRGPNAIDGARPNNPFPIPPPQLEVRRSDTKLSVLPAAVTFWENLGLGPAKGPKDVSAICVYPNFEGVAANADIFLDQMRSVYECSRLGSHDRLVTKDLTNGLMPFTVESPQQNKLHHLSALKDVAARLSRMLSSAEAEEKNFVVYFIYPTDNSALLVHICSAFQHLFNLYRKALSERRVKAANELVLQLIPLDFVSSSTSLAVPLPSDYFRLALEVYDRCIDFISSSSTPAIMLEQPLPKTIDFKLNANPSASLLQENTCLHVGYAQSIDDRWITATWTDNRGTQQMTASYCLGRKNEPISMPFSDVANEIWDTTLDFIAKKKIHWRVMIARVGVMDPSEIDIWTSLASIESDVQLSLTLVSVQTDPSLRLLPASITLAPNSNTATSVVTPVSTPQALQSSMVSPGDAATPARDNVSAATPVDGPVEPDSDARLIDSTDQSWGAILSHRLNNSNSLMELNPALISGYLLKRGGVNIDDPPIIMEVNILHSEVVGNPRTFHEGLLREVLGYYRGLGTLARVRGLVDAVGDVRPWHIAAAEKAVKALYMLM
Length1530
PositionKinase
OrganismHyaloscypha variabilis F
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha variabilis.
Aromaticity0.07
Grand average of hydropathy-0.315
Instability index41.42
Isoelectric point5.08
Molecular weight166996.65
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17717
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.17|      35|      74|     272|     309|       1
---------------------------------------------------------------------------
  272-  309 (55.26/41.30)	NTpSKLAPGASLWLAPGGNAAKFhsYNDE.KNLPTS..LPI
  346-  383 (56.90/31.49)	NT.STLEDGGWLFVQVVGSHPPY..FNGEfQGLPVSeeLAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.68|      36|     318|     140|     181|       2
---------------------------------------------------------------------------
  140-  181 (55.42/45.04)	QA.LNARAIQtnlalGVMQEPPTPSPGArSAGADTPTSLKVIH
  450-  486 (62.26/35.29)	QAdVEARALQ.....AITYSPATLRRGS.NAGAMYPTPPDAPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.56|      25|      29|    1350|    1376|       3
---------------------------------------------------------------------------
 1350- 1376 (37.13/26.93)	LR...LLPASITLAPNSNtaTSVVTPVSTP
 1379- 1406 (38.43/21.68)	LQssmVSPGDAATPARDN..VSAATPVDGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.14|      14|      30|    1174|    1187|       4
---------------------------------------------------------------------------
 1174- 1187 (26.73/17.27)	DFVSSSTSLAV....PLP
 1203- 1220 (22.41/12.95)	DFISSSSTPAImleqPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.87|      24|     448|     862|     887|       5
---------------------------------------------------------------------------
  862-  887 (41.54/29.72)	QIPLMeaDPADWSLTTYFTSPEPDIQ
 1313- 1336 (42.32/24.32)	RVGVM..DPSEIDIWTSLASIESDVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.86|      52|     192|     777|     831|       7
---------------------------------------------------------------------------
  777-  831 (84.02/49.58)	LNQNeLDQP....TDSREP..IDYLMDSDGASQVSEQDDTSHGTNDLSVLphPGLKRKWEN
  967- 1024 (85.84/41.59)	LNQG.LRLPprpiVNHRGPnaIDGARPNNPFPIPPPQLEVRRSDTKLSVL..PAAVTFWEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.74|      25|      84|     313|     343|       9
---------------------------------------------------------------------------
  317-  341 (46.49/38.25)	TENRPNGISSLTIKSWQSKCLEWLS
 1076- 1100 (45.26/20.56)	TKDLTNGLMPFTVESPQQNKLHHLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.52|      26|     930|     522|     547|      11
---------------------------------------------------------------------------
  522-  547 (48.49/29.45)	VANDGDADL.......WGS..SGKKERNNSAMAFN
 1407- 1441 (37.03/20.70)	VEPDSDARLidstdqsWGAilSHRLNNSNSLMELN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.28|      20|      23|     683|     704|      13
---------------------------------------------------------------------------
  683-  704 (28.41/28.65)	KEMVFKRLQRDTSRLvgSTNQK
  708-  727 (31.87/23.53)	RASLFNRVDFEDALL..SVNAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.50|      34|     532|     200|     236|      16
---------------------------------------------------------------------------
  200-  236 (53.77/53.73)	HGFVPLNSR.....TLILTPLkPRCKgyYLSKHAQF.TNDIEL
  731-  770 (50.73/36.94)	HGQFNFNSKlkprqATIKTEL.PQTR..YLSSRRRIrENGQEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17717 with Med13 domain of Kingdom Fungi
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