<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17714

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMENGRNGSHTNHDRDQRLNGVNGANYAPEKSPEKGKGRAEPQQSMTPISPTIPNGVNGNFLDASQQQNGLGDSIPQDLQERINQLPPEIAHITQGYLPLSRLLSRLAQKTHSDLSSTILELAQMPVPSSAVNGNTSHITTSDDSSPENLTKKLRLVKFAQDAHTEWTKALVITGWSRRAEDVSRTIDLKIHLDDQAQYYENAVYELGEVKKGLIHARLPNPDLPTALEVLTTGKASWMPDLGYIQPPPLNAKEILKSLENLNTLLSIRLNLHDYDSIPFHFKNFEIKSGRVTFKVAGEFEIDLTIADEDPEAQFWFIDFRFMFLPSVPTLTPQIRYHIESKVNEALAKDGLAGCYKYLHEMVLTHKINEFKKQAFDLAGAKWIETLKVEALNRALSVQYWLDRYPKGLRSWIILGVHSGKRKDGRPDPKATSRLFIRWFRDSKEVPDVDVQFDTVNITTESLLKTVIAKHVSYILTSIHDNLAAKPLFANRELALSLSISSTEPAESELKVQLTNEQHLTVKIEPISGRILFSPASQLNTKCESQLNGKSPNPAIDGHSYIEVLRGQLLAEEIVNRGLSIGWIRIPIPGLKADALQPYLPKGPQPNFLWFRRSGWAENWCIAVMMTTGGEQWLLLETADAPPNNSSSNVAQGRRITSFIKIPSKLASPVPTYEFLSTLNIFSAALVSHYCNLRSLHGKRAAHMLRQSGPSKAVTLPSIYIRLSEILVSKGKSARTNKEWAKGVVRLTFQGLELLPPKSDDAIPPVPENQPSGDLVQRRPTPQERAVLISEARMIVPPPGQPNVLVNINEKVDKDIAFDPETGSFAFRLRSRVGESVIPDLIERLVRVERLVEFIQVFQKHEKALKCESVSLGKIVFTYGNIAAGNRSDAMDLDTTTSHPYKATVDFNAMETSMTLVLERHNPHLRILDYLVMVLNGSGGLNDVASLLPLTLPVLRGLDAIETAWTPAPDTEKGEVFVNVRAVDWYMIRYDLKQTASTPDSPPTMRKIMFEVRLRHRRGEPWWYVRRSDTINRTSKDVDEIDEALKSVWKSKGTGWEGMRVSGVAQVHGVEELLEKVDEVIRCLPILNAEAPNAPAPTLAAVPAAALSKQVRPQAPQQQQRQQPTPNQSQGQSQSQGRSNPLKREVVEID
Length1154
PositionTail
OrganismHyaloscypha variabilis F
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha> Hyaloscypha variabilis.
Aromaticity0.07
Grand average of hydropathy-0.370
Instability index46.54
Isoelectric point7.99
Molecular weight128886.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17714
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.83|      20|      30|     750|     769|       1
---------------------------------------------------------------------------
  750-  769 (35.62/16.99)	RLTFQGLELLPPKSDDAIPP
  783-  802 (35.21/16.72)	RPTPQERAVLISEARMIVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     371.20|     159|     316|     131|     311|       2
---------------------------------------------------------------------------
  131-  257 (132.78/126.31)	..............................................................VPSSAVNGNTSHITTsddsspENLTKKL..RLVKFA.QDAHTEW.TKALVIT.....GWSrraedVSRT....IDLKIHLDDQaQYYenavyelgEVKKGLIHARL...PNPDLPTALEVLTTGKaSWMPDL.G..YIQ..PPPLNAK
  258-  311 (36.33/14.65)	EILKsLENLNTLLSIRLNLHDYDS.....IPFHFKNFEIKSGRVTFKVAGEFEID.LTIA......................................................................................................................................................
  389-  576 (202.10/128.81)	ETLK.VEALNRALSVQYWLDRYPKglrswIILGVHSGKRKDGRPDPKATSRLFIRwFRDSkeVPDVDVQFDTVNITT......ESLLKTViaKHVSYIlTSIHDNLaAKPLFANrelalSLS.....ISSTepaeSELKVQLTNE.QHL........TVKIEPISGRIlfsPASQLNTKCESQLNGK.SPNPAIdGhsYIEvlRGQLLAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.76|      22|      33|      24|      46|       3
---------------------------------------------------------------------------
   24-   46 (37.06/30.53)	NGVNGaNYAPEKSPEKGKGRAEP
   59-   80 (40.69/28.45)	NGVNG.NFLDASQQQNGLGDSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.82|      30|      35|     963|     995|       4
---------------------------------------------------------------------------
  966-  995 (56.69/37.37)	ETAWTPAPDTEKGEVFVNVRAVD......WYMIRYD
  998- 1033 (50.13/25.22)	QTASTPDSPPTMRKIMFEVRLRHrrgepwWYVRRSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      19|      33|     911|     933|       5
---------------------------------------------------------------------------
  911-  933 (28.47/29.33)	FNAMETSMTLVLerhnPHLRILD
  945-  963 (32.19/20.62)	LNDVASLLPLTL....PVLRGLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17714 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMENGRNGSHTNHDRDQRLNGVNGANYAPEKSPEKGKGRAEPQQSMTPISPTIPNGVNGNFLDASQQQNGLGDSIPQDLQERINQLPP
2) PNAPAPTLAAVPAAALSKQVRPQAPQQQQRQQPTPNQSQGQSQSQGRSNPLKREVVEID
1
1096
92
1154










Molecular Recognition Features






MoRF SequenceStartStop




1) LKREVVEI
2) LSKQVR
1146
1111
1153
1116